Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study

Elisabeth Svensson, Klara Berencsi, Simone Sander, Anil Mor, Jørgen Rungby, Jens Steen Nielsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.

METHODS: We conducted a cross-sectional study based on the Danish Centre for Strategic Research in Type 2 Diabetes cohort. We examined the prevalence ratios (PR) of demographic, lifestyle, anthropometric, and clinical factors according to parental history, using Poisson regression adjusting for age and gender.

RESULTS: Of 2825 T2D patients, 34% (n = 964) had a parental history of T2D. Parental history was associated with younger age at diagnosis [adjusted (a)PR 1.66, 95% confidence interval: 1.19, 2.31) for age <40 years; aPR 1.36 (95% confidence interval: 1.24, 1.48) for ages 40-59 years] and with higher baseline fasting plasma glucose [≥7.5 mmol/L, aPR 1.47 (95% confidence interval: 1.20, 1.80)], and also tended to be associated with lower beta cell function. In contrast, patients both with and without a parental history had similar occurrence of central obesity [91% vs. 91%], weight gain ≥30 kg since age 20 [52% vs. 53%], and lack of regular physical activity [60% vs. 58%]. Presence of diabetes complications or comorbidities at T2D diagnosis was not associated with parental history.

CONCLUSIONS: The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis. Copyright © 2015 John Wiley & Sons, Ltd.

OriginalsprogEngelsk
TidsskriftDiabetes - Metabolism: Research and Reviews (Print Edition)
Vol/bind32
Udgave nummer3
Sider (fra-til)308-315
ISSN1520-7552
DOI
StatusUdgivet - 2016

Fingeraftryk

Medical problems
Type 2 Diabetes Mellitus
Confidence Intervals
Abdominal Obesity
Insulin-Secreting Cells
Diabetes Complications
Nuclear Family
Weight Gain
Comorbidity
Fasting
Cross-Sectional Studies
Exercise
Plasmas
Glucose
Research

Bibliografisk note

Article first published online: 6 NOV 2015

Citer dette

Svensson, Elisabeth ; Berencsi, Klara ; Sander, Simone ; Mor, Anil ; Rungby, Jørgen ; Nielsen, Jens Steen ; Friborg, Søren ; Brandslund, Ivan ; Christiansen, Jens Sandahl ; Vaag, Allan ; Beck-Nielsen, Henning ; Sørensen, Henrik Toft ; Thomsen, Reimar Wernich. / Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis : results from the DD2 study. I: Diabetes - Metabolism: Research and Reviews (Print Edition). 2016 ; Bind 32, Nr. 3. s. 308-315.
@article{7ca2ef2627e649149ed16b3d773f21b6,
title = "Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study",
abstract = "BACKGROUND: We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.METHODS: We conducted a cross-sectional study based on the Danish Centre for Strategic Research in Type 2 Diabetes cohort. We examined the prevalence ratios (PR) of demographic, lifestyle, anthropometric, and clinical factors according to parental history, using Poisson regression adjusting for age and gender.RESULTS: Of 2825 T2D patients, 34{\%} (n = 964) had a parental history of T2D. Parental history was associated with younger age at diagnosis [adjusted (a)PR 1.66, 95{\%} confidence interval: 1.19, 2.31) for age <40 years; aPR 1.36 (95{\%} confidence interval: 1.24, 1.48) for ages 40-59 years] and with higher baseline fasting plasma glucose [≥7.5 mmol/L, aPR 1.47 (95{\%} confidence interval: 1.20, 1.80)], and also tended to be associated with lower beta cell function. In contrast, patients both with and without a parental history had similar occurrence of central obesity [91{\%} vs. 91{\%}], weight gain ≥30 kg since age 20 [52{\%} vs. 53{\%}], and lack of regular physical activity [60{\%} vs. 58{\%}]. Presence of diabetes complications or comorbidities at T2D diagnosis was not associated with parental history.CONCLUSIONS: The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis. Copyright {\circledC} 2015 John Wiley & Sons, Ltd.",
author = "Elisabeth Svensson and Klara Berencsi and Simone Sander and Anil Mor and J{\o}rgen Rungby and Nielsen, {Jens Steen} and S{\o}ren Friborg and Ivan Brandslund and Christiansen, {Jens Sandahl} and Allan Vaag and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft} and Thomsen, {Reimar Wernich}",
note = "Article first published online: 6 NOV 2015",
year = "2016",
doi = "10.1002/dmrr.2721",
language = "English",
volume = "32",
pages = "308--315",
journal = "Diabetes - Metabolism: Research and Reviews (Print Edition)",
issn = "1520-7552",
publisher = "John Wiley & Sons Ltd",
number = "3",

}

Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis : results from the DD2 study. / Svensson, Elisabeth; Berencsi, Klara; Sander, Simone; Mor, Anil; Rungby, Jørgen; Nielsen, Jens Steen; Friborg, Søren; Brandslund, Ivan; Christiansen, Jens Sandahl; Vaag, Allan; Beck-Nielsen, Henning; Sørensen, Henrik Toft; Thomsen, Reimar Wernich.

I: Diabetes - Metabolism: Research and Reviews (Print Edition), Bind 32, Nr. 3, 2016, s. 308-315.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis

T2 - results from the DD2 study

AU - Svensson, Elisabeth

AU - Berencsi, Klara

AU - Sander, Simone

AU - Mor, Anil

AU - Rungby, Jørgen

AU - Nielsen, Jens Steen

AU - Friborg, Søren

AU - Brandslund, Ivan

AU - Christiansen, Jens Sandahl

AU - Vaag, Allan

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

AU - Thomsen, Reimar Wernich

N1 - Article first published online: 6 NOV 2015

PY - 2016

Y1 - 2016

N2 - BACKGROUND: We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.METHODS: We conducted a cross-sectional study based on the Danish Centre for Strategic Research in Type 2 Diabetes cohort. We examined the prevalence ratios (PR) of demographic, lifestyle, anthropometric, and clinical factors according to parental history, using Poisson regression adjusting for age and gender.RESULTS: Of 2825 T2D patients, 34% (n = 964) had a parental history of T2D. Parental history was associated with younger age at diagnosis [adjusted (a)PR 1.66, 95% confidence interval: 1.19, 2.31) for age <40 years; aPR 1.36 (95% confidence interval: 1.24, 1.48) for ages 40-59 years] and with higher baseline fasting plasma glucose [≥7.5 mmol/L, aPR 1.47 (95% confidence interval: 1.20, 1.80)], and also tended to be associated with lower beta cell function. In contrast, patients both with and without a parental history had similar occurrence of central obesity [91% vs. 91%], weight gain ≥30 kg since age 20 [52% vs. 53%], and lack of regular physical activity [60% vs. 58%]. Presence of diabetes complications or comorbidities at T2D diagnosis was not associated with parental history.CONCLUSIONS: The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis. Copyright © 2015 John Wiley & Sons, Ltd.

AB - BACKGROUND: We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.METHODS: We conducted a cross-sectional study based on the Danish Centre for Strategic Research in Type 2 Diabetes cohort. We examined the prevalence ratios (PR) of demographic, lifestyle, anthropometric, and clinical factors according to parental history, using Poisson regression adjusting for age and gender.RESULTS: Of 2825 T2D patients, 34% (n = 964) had a parental history of T2D. Parental history was associated with younger age at diagnosis [adjusted (a)PR 1.66, 95% confidence interval: 1.19, 2.31) for age <40 years; aPR 1.36 (95% confidence interval: 1.24, 1.48) for ages 40-59 years] and with higher baseline fasting plasma glucose [≥7.5 mmol/L, aPR 1.47 (95% confidence interval: 1.20, 1.80)], and also tended to be associated with lower beta cell function. In contrast, patients both with and without a parental history had similar occurrence of central obesity [91% vs. 91%], weight gain ≥30 kg since age 20 [52% vs. 53%], and lack of regular physical activity [60% vs. 58%]. Presence of diabetes complications or comorbidities at T2D diagnosis was not associated with parental history.CONCLUSIONS: The lack of an association between parental history and adverse lifestyle factors indicates that T2D patients do not inherit a particular propensity for overeating or inactivity, whereas patients with a parental history may have more severe pancreatic beta cell dysfunction at diagnosis. Copyright © 2015 John Wiley & Sons, Ltd.

U2 - 10.1002/dmrr.2721

DO - 10.1002/dmrr.2721

M3 - Journal article

C2 - 26408959

VL - 32

SP - 308

EP - 315

JO - Diabetes - Metabolism: Research and Reviews (Print Edition)

JF - Diabetes - Metabolism: Research and Reviews (Print Edition)

SN - 1520-7552

IS - 3

ER -