Association of high amounts of physical activity with mortality risk

A systematic review and meta-analysis

Kim Blond*, Cecilie Fau Brinkløv, Mathias Ried-Larsen, Alessio Crippa, Anders Grøntved

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Objectives: To systematically review and analyse studies of high amounts of physical activity and mortality risk in the general population. Eligibility criteria: Inclusion criteria related to follow-up (minimum 2 years), outcome (mortality from all causes, cancer, cardiovascular disease (CVD) or coronary heart disease), exposure (eg, a category of >1000 metabolic equivalent of task (MET) min/week), study design (prospective cohort, nested case control or case-cohort) and reports of cases and person years of exposure categories. Information sources: Systematic searches were conducted in Embase and Pubmed from database inception to 2 March 2019. Risk of bias: The quality of the studies was assessed with the Newcastle-Ottawa scale. Included studies: From 31 368 studies identified, 48 were included. Two authors independently extracted outcome estimates and assessed study quality. Synthesis of results: We estimated hazard ratios (HRs) using random effect restricted cubic spline dose-response meta-analyses. Compared with the recommended level of physical activity (750 MET min/week), mortality risk was lower at physical activity levels exceeding the recommendations, at least until 5000 MET min/week for all cause mortality (HR=0.86, 95% CI 0.78 to 0.94) and for CVD mortality (HR=0.73, 95% CI 0.56 to 0.95). Strengths and limitations of evidence: The strengths of this study include the detailed dose-response analyses, inclusion of 48 studies and examination of sources of heterogeneity. The limitations include the observational nature of the included studies and the inaccurate estimations of amount of physical activity. Interpretation: Compared with the recommended level, mortality risk was lower at physical activity levels well above the recommended target range. Further, there was no threshold beyond which lifespan was compromised.

OriginalsprogEngelsk
TidsskriftBritish Journal of Sports Medicine
ISSN0306-3674
DOI
StatusE-pub ahead of print - 12. aug. 2019

Fingeraftryk

Meta-Analysis
PubMed
Databases
Prospective Studies
Population
Neoplasms

Citer dette

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abstract = "Objectives: To systematically review and analyse studies of high amounts of physical activity and mortality risk in the general population. Eligibility criteria: Inclusion criteria related to follow-up (minimum 2 years), outcome (mortality from all causes, cancer, cardiovascular disease (CVD) or coronary heart disease), exposure (eg, a category of >1000 metabolic equivalent of task (MET) min/week), study design (prospective cohort, nested case control or case-cohort) and reports of cases and person years of exposure categories. Information sources: Systematic searches were conducted in Embase and Pubmed from database inception to 2 March 2019. Risk of bias: The quality of the studies was assessed with the Newcastle-Ottawa scale. Included studies: From 31 368 studies identified, 48 were included. Two authors independently extracted outcome estimates and assessed study quality. Synthesis of results: We estimated hazard ratios (HRs) using random effect restricted cubic spline dose-response meta-analyses. Compared with the recommended level of physical activity (750 MET min/week), mortality risk was lower at physical activity levels exceeding the recommendations, at least until 5000 MET min/week for all cause mortality (HR=0.86, 95{\%} CI 0.78 to 0.94) and for CVD mortality (HR=0.73, 95{\%} CI 0.56 to 0.95). Strengths and limitations of evidence: The strengths of this study include the detailed dose-response analyses, inclusion of 48 studies and examination of sources of heterogeneity. The limitations include the observational nature of the included studies and the inaccurate estimations of amount of physical activity. Interpretation: Compared with the recommended level, mortality risk was lower at physical activity levels well above the recommended target range. Further, there was no threshold beyond which lifespan was compromised.",
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Association of high amounts of physical activity with mortality risk : A systematic review and meta-analysis. / Blond, Kim; Brinkløv, Cecilie Fau; Ried-Larsen, Mathias; Crippa, Alessio; Grøntved, Anders.

I: British Journal of Sports Medicine, 12.08.2019.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Association of high amounts of physical activity with mortality risk

T2 - A systematic review and meta-analysis

AU - Blond, Kim

AU - Brinkløv, Cecilie Fau

AU - Ried-Larsen, Mathias

AU - Crippa, Alessio

AU - Grøntved, Anders

PY - 2019/8/12

Y1 - 2019/8/12

N2 - Objectives: To systematically review and analyse studies of high amounts of physical activity and mortality risk in the general population. Eligibility criteria: Inclusion criteria related to follow-up (minimum 2 years), outcome (mortality from all causes, cancer, cardiovascular disease (CVD) or coronary heart disease), exposure (eg, a category of >1000 metabolic equivalent of task (MET) min/week), study design (prospective cohort, nested case control or case-cohort) and reports of cases and person years of exposure categories. Information sources: Systematic searches were conducted in Embase and Pubmed from database inception to 2 March 2019. Risk of bias: The quality of the studies was assessed with the Newcastle-Ottawa scale. Included studies: From 31 368 studies identified, 48 were included. Two authors independently extracted outcome estimates and assessed study quality. Synthesis of results: We estimated hazard ratios (HRs) using random effect restricted cubic spline dose-response meta-analyses. Compared with the recommended level of physical activity (750 MET min/week), mortality risk was lower at physical activity levels exceeding the recommendations, at least until 5000 MET min/week for all cause mortality (HR=0.86, 95% CI 0.78 to 0.94) and for CVD mortality (HR=0.73, 95% CI 0.56 to 0.95). Strengths and limitations of evidence: The strengths of this study include the detailed dose-response analyses, inclusion of 48 studies and examination of sources of heterogeneity. The limitations include the observational nature of the included studies and the inaccurate estimations of amount of physical activity. Interpretation: Compared with the recommended level, mortality risk was lower at physical activity levels well above the recommended target range. Further, there was no threshold beyond which lifespan was compromised.

AB - Objectives: To systematically review and analyse studies of high amounts of physical activity and mortality risk in the general population. Eligibility criteria: Inclusion criteria related to follow-up (minimum 2 years), outcome (mortality from all causes, cancer, cardiovascular disease (CVD) or coronary heart disease), exposure (eg, a category of >1000 metabolic equivalent of task (MET) min/week), study design (prospective cohort, nested case control or case-cohort) and reports of cases and person years of exposure categories. Information sources: Systematic searches were conducted in Embase and Pubmed from database inception to 2 March 2019. Risk of bias: The quality of the studies was assessed with the Newcastle-Ottawa scale. Included studies: From 31 368 studies identified, 48 were included. Two authors independently extracted outcome estimates and assessed study quality. Synthesis of results: We estimated hazard ratios (HRs) using random effect restricted cubic spline dose-response meta-analyses. Compared with the recommended level of physical activity (750 MET min/week), mortality risk was lower at physical activity levels exceeding the recommendations, at least until 5000 MET min/week for all cause mortality (HR=0.86, 95% CI 0.78 to 0.94) and for CVD mortality (HR=0.73, 95% CI 0.56 to 0.95). Strengths and limitations of evidence: The strengths of this study include the detailed dose-response analyses, inclusion of 48 studies and examination of sources of heterogeneity. The limitations include the observational nature of the included studies and the inaccurate estimations of amount of physical activity. Interpretation: Compared with the recommended level, mortality risk was lower at physical activity levels well above the recommended target range. Further, there was no threshold beyond which lifespan was compromised.

KW - cardiovascular

KW - Death

KW - meta-analysis

KW - physical activity

U2 - 10.1136/bjsports-2018-100393

DO - 10.1136/bjsports-2018-100393

M3 - Review

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

ER -