Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study

LLFS Research Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Background: Fatigue, inflammation, and physical activity (PA) are all independently associated with gait speed, but their directionality is not fully elucidated. Aims: Evaluate the bidirectional associations amongst fatigue, inflammation, and PA on gait speed. Methods: This cross sectional study included probands (n = 1280, aged 49–105) and offspring (n = 2772, aged 24–88) in the Long Life Family Study. We assessed gait speed, fatigue with the question “I could not get going”, inflammation using fasting interleukin-6 (IL-6) and high sensitivity C-reactive protein (CRP), and self-reported PA as walking frequency in the past two weeks. The two generations were examined separately using linear mixed modeling. Results: Lower fatigue, lower IL-6, and greater PA were all associated with faster gait speed in both generations (all p < 0.05); lower CRP was only associated with faster gait speed in the offspring. PA explained the association of fatigue and gait speed via a 16.1% (95% CI 9.7%, 26.7%) attenuation of the direct associations for the probands and 9.9% (95% CI 6.3%, 18.8%) in the offspring. In addition, IL-6 explained more of the association of fatigue and gait speed than the association between PA and gait speed, via a 14.9% (95% CI 9.2%, 23.4%) attenuation of the direct association in the offspring only. Discussion: Results revealed a potential directionality from fatigue to IL-6 to PA that may lead to faster gait speed. Future work should examine these relationships longitudinally to establish temporality and causality. Conclusions: Our findings support a signal that lowering fatigue and inflammation and increasing physical activity may delay functional decline.

OriginalsprogEngelsk
TidsskriftAging Clinical and Experimental Research
ISSN1594-0667
DOI
StatusE-pub ahead of print - 2021

Bibliografisk note

Funding Information:
The Long Life Family Study is sponsored by the National Institute on Aging U01-AG023712, U01-AG23744, U01-AG023746, U01-AG023749 and U01-AG02375, P01-AG08761, and U19-AG063893. TG was supported by the National Institute on Aging, Epidemiology of Aging training grant at the University of Pittsburgh (T32-AG00018). AJS was supported by a career development award from the National Institute on Aging (K01-AG057726).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Fingeraftryk

Dyk ned i forskningsemnerne om 'Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study'. Sammen danner de et unikt fingeraftryk.

Citationsformater