Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance

Influence of adolescence and psychological stress

Camilla F Thomsen, Rasmus Dreier, Tina S Goharian, Jens P Goetze, Lars B Andersen, Jens Faber, Mathias Ried-Larsen, Anders Grøntved, Jørgen L Jeppesen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95%CI) = 0.19 (0.11 to 0.27), P < 0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P = 0.78). MDI score associated with IR (B = 0.010 (0.004 to 0.016), P < 0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

OriginalsprogEngelsk
TidsskriftPeptides
Vol/bind115
Sider (fra-til)8-14
ISSN0196-9781
DOI
StatusUdgivet - maj 2019

Fingeraftryk

Arginine Vasopressin
Insulin Resistance
Insulin
Young Adult
Depression
Equipment and Supplies
Confidence Intervals
copeptins
Linear regression
Linear Models
Age Groups
Plasmas

Citer dette

Thomsen, Camilla F ; Dreier, Rasmus ; Goharian, Tina S ; Goetze, Jens P ; Andersen, Lars B ; Faber, Jens ; Ried-Larsen, Mathias ; Grøntved, Anders ; Jeppesen, Jørgen L. / Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance : Influence of adolescence and psychological stress. I: Peptides. 2019 ; Bind 115. s. 8-14.
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title = "Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: Influence of adolescence and psychological stress",
abstract = "In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95{\%} confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95{\%}CI) = 0.19 (0.11 to 0.27), P < 0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P = 0.78). MDI score associated with IR (B = 0.010 (0.004 to 0.016), P < 0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.",
keywords = "Arginine vasopressin, Copeptin, Depression, Insulin, Insulin resistance, Psychological stress",
author = "Thomsen, {Camilla F} and Rasmus Dreier and Goharian, {Tina S} and Goetze, {Jens P} and Andersen, {Lars B} and Jens Faber and Mathias Ried-Larsen and Anders Gr{\o}ntved and Jeppesen, {J{\o}rgen L}",
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year = "2019",
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language = "English",
volume = "115",
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Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance : Influence of adolescence and psychological stress. / Thomsen, Camilla F; Dreier, Rasmus; Goharian, Tina S; Goetze, Jens P; Andersen, Lars B; Faber, Jens; Ried-Larsen, Mathias; Grøntved, Anders; Jeppesen, Jørgen L.

I: Peptides, Bind 115, 05.2019, s. 8-14.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance

T2 - Influence of adolescence and psychological stress

AU - Thomsen, Camilla F

AU - Dreier, Rasmus

AU - Goharian, Tina S

AU - Goetze, Jens P

AU - Andersen, Lars B

AU - Faber, Jens

AU - Ried-Larsen, Mathias

AU - Grøntved, Anders

AU - Jeppesen, Jørgen L

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/5

Y1 - 2019/5

N2 - In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95%CI) = 0.19 (0.11 to 0.27), P < 0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P = 0.78). MDI score associated with IR (B = 0.010 (0.004 to 0.016), P < 0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

AB - In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95%CI) = 0.19 (0.11 to 0.27), P < 0.001). This association was not found among the adolescents (B=-0.01 (-0.12 to 0.09), P = 0.78). MDI score associated with IR (B = 0.010 (0.004 to 0.016), P < 0.001) and copeptin (B=0.010 (0.004 to 0.015); P<0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B=0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.

KW - Arginine vasopressin

KW - Copeptin

KW - Depression

KW - Insulin

KW - Insulin resistance

KW - Psychological stress

U2 - 10.1016/j.peptides.2019.02.005

DO - 10.1016/j.peptides.2019.02.005

M3 - Journal article

VL - 115

SP - 8

EP - 14

JO - Peptides

JF - Peptides

SN - 0196-9781

ER -