Association of coexisting diabetes and depression with mortality after myocardial infarction

Mariska Bot, Francois Pouwer, Marij Zuidersma, Joost P van Melle, Peter de Jonge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: Diabetes and depression are both linked to an increased mortality risk after myocardial infarction (MI). Population-based studies suggest that having both diabetes and depression results in an increased mortality risk, beyond that of having diabetes or depression alone. The purpose of this study was to examine the joint association of diabetes and depression with mortality in MI patients.

RESEARCH DESIGN AND METHODS: Data were derived from two multicenter cohort studies in the Netherlands, comprising 2,704 patients who were hospitalized for MI. Depression, defined as a Beck Depression Inventory score ≥10, and diabetes were assessed during hospitalization. Mortality data were retrieved for 2,525 patients (93%).

RESULTS: During an average follow-up of 6.2 years, 439 patients died. The mortality rate was 14% (226 of 1,673) in patients without diabetes and depression, 23% (49 of 210) in patients with diabetes only, 22% (118 of 544) in patients with depression only, and 47% (46 of 98) in patients with both diabetes and depression. After adjustment for age, sex, smoking, hypertension, left ventricular ejection fraction, prior MI, and Killip class, hazard ratios for all-cause mortality were 1.38 (95% CI 1.00-1.90) for patients with diabetes only, 1.39 (1.10-1.76) for patients with depression only, and as much as 2.90 (2.07-4.07) for patients with both diabetes and depression.

CONCLUSIONS: We observed an increased mortality risk in post-MI patients with both diabetes and depression, beyond the association with mortality of diabetes and depression alone.

OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind35
Udgave nummer3
Sider (fra-til)503-509
ISSN0149-5992
DOI
StatusUdgivet - 2012
Udgivet eksterntJa

Fingeraftryk

Depression
Netherlands
Multicenter Studies
Cohort Studies
Smoking
Equipment and Supplies
Population

Citer dette

Bot, Mariska ; Pouwer, Francois ; Zuidersma, Marij ; van Melle, Joost P ; de Jonge, Peter. / Association of coexisting diabetes and depression with mortality after myocardial infarction. I: Diabetes Care. 2012 ; Bind 35, Nr. 3. s. 503-509.
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abstract = "OBJECTIVE: Diabetes and depression are both linked to an increased mortality risk after myocardial infarction (MI). Population-based studies suggest that having both diabetes and depression results in an increased mortality risk, beyond that of having diabetes or depression alone. The purpose of this study was to examine the joint association of diabetes and depression with mortality in MI patients.RESEARCH DESIGN AND METHODS: Data were derived from two multicenter cohort studies in the Netherlands, comprising 2,704 patients who were hospitalized for MI. Depression, defined as a Beck Depression Inventory score ≥10, and diabetes were assessed during hospitalization. Mortality data were retrieved for 2,525 patients (93{\%}).RESULTS: During an average follow-up of 6.2 years, 439 patients died. The mortality rate was 14{\%} (226 of 1,673) in patients without diabetes and depression, 23{\%} (49 of 210) in patients with diabetes only, 22{\%} (118 of 544) in patients with depression only, and 47{\%} (46 of 98) in patients with both diabetes and depression. After adjustment for age, sex, smoking, hypertension, left ventricular ejection fraction, prior MI, and Killip class, hazard ratios for all-cause mortality were 1.38 (95{\%} CI 1.00-1.90) for patients with diabetes only, 1.39 (1.10-1.76) for patients with depression only, and as much as 2.90 (2.07-4.07) for patients with both diabetes and depression.CONCLUSIONS: We observed an increased mortality risk in post-MI patients with both diabetes and depression, beyond the association with mortality of diabetes and depression alone.",
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pages = "503--509",
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Association of coexisting diabetes and depression with mortality after myocardial infarction. / Bot, Mariska; Pouwer, Francois; Zuidersma, Marij; van Melle, Joost P; de Jonge, Peter.

I: Diabetes Care, Bind 35, Nr. 3, 2012, s. 503-509.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association of coexisting diabetes and depression with mortality after myocardial infarction

AU - Bot, Mariska

AU - Pouwer, Francois

AU - Zuidersma, Marij

AU - van Melle, Joost P

AU - de Jonge, Peter

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: Diabetes and depression are both linked to an increased mortality risk after myocardial infarction (MI). Population-based studies suggest that having both diabetes and depression results in an increased mortality risk, beyond that of having diabetes or depression alone. The purpose of this study was to examine the joint association of diabetes and depression with mortality in MI patients.RESEARCH DESIGN AND METHODS: Data were derived from two multicenter cohort studies in the Netherlands, comprising 2,704 patients who were hospitalized for MI. Depression, defined as a Beck Depression Inventory score ≥10, and diabetes were assessed during hospitalization. Mortality data were retrieved for 2,525 patients (93%).RESULTS: During an average follow-up of 6.2 years, 439 patients died. The mortality rate was 14% (226 of 1,673) in patients without diabetes and depression, 23% (49 of 210) in patients with diabetes only, 22% (118 of 544) in patients with depression only, and 47% (46 of 98) in patients with both diabetes and depression. After adjustment for age, sex, smoking, hypertension, left ventricular ejection fraction, prior MI, and Killip class, hazard ratios for all-cause mortality were 1.38 (95% CI 1.00-1.90) for patients with diabetes only, 1.39 (1.10-1.76) for patients with depression only, and as much as 2.90 (2.07-4.07) for patients with both diabetes and depression.CONCLUSIONS: We observed an increased mortality risk in post-MI patients with both diabetes and depression, beyond the association with mortality of diabetes and depression alone.

AB - OBJECTIVE: Diabetes and depression are both linked to an increased mortality risk after myocardial infarction (MI). Population-based studies suggest that having both diabetes and depression results in an increased mortality risk, beyond that of having diabetes or depression alone. The purpose of this study was to examine the joint association of diabetes and depression with mortality in MI patients.RESEARCH DESIGN AND METHODS: Data were derived from two multicenter cohort studies in the Netherlands, comprising 2,704 patients who were hospitalized for MI. Depression, defined as a Beck Depression Inventory score ≥10, and diabetes were assessed during hospitalization. Mortality data were retrieved for 2,525 patients (93%).RESULTS: During an average follow-up of 6.2 years, 439 patients died. The mortality rate was 14% (226 of 1,673) in patients without diabetes and depression, 23% (49 of 210) in patients with diabetes only, 22% (118 of 544) in patients with depression only, and 47% (46 of 98) in patients with both diabetes and depression. After adjustment for age, sex, smoking, hypertension, left ventricular ejection fraction, prior MI, and Killip class, hazard ratios for all-cause mortality were 1.38 (95% CI 1.00-1.90) for patients with diabetes only, 1.39 (1.10-1.76) for patients with depression only, and as much as 2.90 (2.07-4.07) for patients with both diabetes and depression.CONCLUSIONS: We observed an increased mortality risk in post-MI patients with both diabetes and depression, beyond the association with mortality of diabetes and depression alone.

KW - Aged

KW - Cohort Studies

KW - Depression

KW - Diabetes Mellitus

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.2337/dc11-1749

DO - 10.2337/dc11-1749

M3 - Journal article

VL - 35

SP - 503

EP - 509

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 3

ER -