Abstrakt
Natriuretic peptides are produced within the heart and released in response to increased chamber wall tension and heart failure (HF). N-Terminal prohormone Brain Natriuretic Peptide (NT-proBNP) is a specific natriuretic peptide commonly assayed in persons at risk for HF. In these individuals, NT-proBNP is associated with future disease prognosis and mortality. However, its association with mortality among healthy older adults remains unknown. Therefore, we determined the association of NT-proBNP with all-cause mortality over a median follow-up of 10 years in 3253 individuals free from HF at baseline in the Long Life Family Study, a study of families recruited for exceptional longevity. We performed cox proportional hazards analysis (coxme in R) for time-to event (mortality), adjusted for field center, familial relatedness, age, sex, education, smoking, alcohol, physical activity, BMI, diabetes, hypertension, and cancer. In addition, we performed secondary analyses among individuals (N=2457) within the normal NT-proBNP limits at baseline (\lt;125pg/ml aged \lt;75 years; \lt;450pg/ml aged ≥75 years). Overall, individuals were aged 32-110 years (median 67 years; 44\, had mean NT-proBNP of 318.5 pg/ml (median 91.0 pg/ml) and 1066 individuals (33\ died over the follow-up period. After adjustment, each 1 SD greater baseline NT-proBNP was associated with a 1.30-times increased hazard of mortality (95\ 1.24-1.36; P\lt;0.0001). Results were similar in individuals with normal baseline NT-proBNP (HR: 1.21; 95\ 1.11-1.32; P\lt;0.0001). These results suggest that NT-proBNP is a strong and specific biomarker for mortality in older adults independent of current health status, even in those with clinically-defined normal NT-proBNP.
Originalsprog | Engelsk |
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Tidsskrift | Innovation in Aging |
Vol/bind | 4 |
Udgave nummer | Suppl. 1 |
Sider (fra-til) | 211-211 |
Antal sider | 1 |
ISSN | 2399-5300 |
DOI | |
Status | Udgivet - 2020 |
Begivenhed | GSA 2020 Annual Scientific Meeting Online - Varighed: 4. nov. 2020 → 7. nov. 2020 https://www.geron.org/meetings-events/gsa-2020-annual-scientific-meeting |
Konference
Konference | GSA 2020 Annual Scientific Meeting Online |
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Periode | 04/11/2020 → 07/11/2020 |
Internetadresse |