Association between positive patch tests to epoxy resin and fragrance mix I ingredients

Klaus Ejner Andersen, Lars Porskjaer Christensen, Aage Vølund, Jeanne Duus Johansen, Evy Paulsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Mar
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind60
Udgave nummer3
Sider (fra-til)155-7
Antal sider2
ISSN0105-1873
DOI
StatusUdgivet - 1. mar. 2009

Fingeraftryk

Patch Tests
Eczema
Dermatology
Allergens
Odds Ratio
Population

Citer dette

Andersen, Klaus Ejner ; Christensen, Lars Porskjaer ; Vølund, Aage ; Johansen, Jeanne Duus ; Paulsen, Evy. / Association between positive patch tests to epoxy resin and fragrance mix I ingredients. I: Contact Dermatitis. 2009 ; Bind 60, Nr. 3. s. 155-7.
@article{81526040155011deb27a000ea68e967b,
title = "Association between positive patch tests to epoxy resin and fragrance mix I ingredients",
abstract = "BACKGROUND: Both epoxy resin (diglycidyl ether of bisphenol A) and fragrance mix I are included in the European baseline series of contact allergens. A significant association between positive reactions to epoxy resin and fragrance mix has been reported by others. OBJECTIVE: To investigate and possibly reproduce this association with the use of TRUE((R)) test data and supplementary tests with fragrance mix ingredients from the Department of Dermatology, Odense University Hospital. MATERIALS AND METHODS: Six thousand one hundred and fifteen consecutive eczema patients tested from 1995 to 2007 were included, and test results from all patients tested with fragrance mix ingredients were analysed. RESULTS: One hundred and forty-five (2.4{\%}) were positive to epoxy resin and 282 (4.6{\%}) were positive to fragrance mix I. Nineteen were positive to both giving an odds ratio of 3.3, which is significant (95{\%} CI 2.0-5.4). Analysis of association to individual fragrance mix ingredients showed a significant association to alpha-amyl cinnamal and isoeugenol. CONCLUSIONS: The significant association between positive reactions to epoxy resin and fragrance mix I was reproduced. However, the clinical implications are not clarified, and even though the association may be coincidental, the fact that it can be reproduced with a different patch test system and in a different population speaks against a random result. Further studies may help to interpret the association.",
author = "Andersen, {Klaus Ejner} and Christensen, {Lars Porskjaer} and Aage V{\o}lund and Johansen, {Jeanne Duus} and Evy Paulsen",
year = "2009",
month = "3",
day = "1",
doi = "10.1111/j.1600-0536.2008.01498.x",
language = "English",
volume = "60",
pages = "155--7",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "3",

}

Association between positive patch tests to epoxy resin and fragrance mix I ingredients. / Andersen, Klaus Ejner; Christensen, Lars Porskjaer; Vølund, Aage; Johansen, Jeanne Duus; Paulsen, Evy.

I: Contact Dermatitis, Bind 60, Nr. 3, 01.03.2009, s. 155-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association between positive patch tests to epoxy resin and fragrance mix I ingredients

AU - Andersen, Klaus Ejner

AU - Christensen, Lars Porskjaer

AU - Vølund, Aage

AU - Johansen, Jeanne Duus

AU - Paulsen, Evy

PY - 2009/3/1

Y1 - 2009/3/1

N2 - BACKGROUND: Both epoxy resin (diglycidyl ether of bisphenol A) and fragrance mix I are included in the European baseline series of contact allergens. A significant association between positive reactions to epoxy resin and fragrance mix has been reported by others. OBJECTIVE: To investigate and possibly reproduce this association with the use of TRUE((R)) test data and supplementary tests with fragrance mix ingredients from the Department of Dermatology, Odense University Hospital. MATERIALS AND METHODS: Six thousand one hundred and fifteen consecutive eczema patients tested from 1995 to 2007 were included, and test results from all patients tested with fragrance mix ingredients were analysed. RESULTS: One hundred and forty-five (2.4%) were positive to epoxy resin and 282 (4.6%) were positive to fragrance mix I. Nineteen were positive to both giving an odds ratio of 3.3, which is significant (95% CI 2.0-5.4). Analysis of association to individual fragrance mix ingredients showed a significant association to alpha-amyl cinnamal and isoeugenol. CONCLUSIONS: The significant association between positive reactions to epoxy resin and fragrance mix I was reproduced. However, the clinical implications are not clarified, and even though the association may be coincidental, the fact that it can be reproduced with a different patch test system and in a different population speaks against a random result. Further studies may help to interpret the association.

AB - BACKGROUND: Both epoxy resin (diglycidyl ether of bisphenol A) and fragrance mix I are included in the European baseline series of contact allergens. A significant association between positive reactions to epoxy resin and fragrance mix has been reported by others. OBJECTIVE: To investigate and possibly reproduce this association with the use of TRUE((R)) test data and supplementary tests with fragrance mix ingredients from the Department of Dermatology, Odense University Hospital. MATERIALS AND METHODS: Six thousand one hundred and fifteen consecutive eczema patients tested from 1995 to 2007 were included, and test results from all patients tested with fragrance mix ingredients were analysed. RESULTS: One hundred and forty-five (2.4%) were positive to epoxy resin and 282 (4.6%) were positive to fragrance mix I. Nineteen were positive to both giving an odds ratio of 3.3, which is significant (95% CI 2.0-5.4). Analysis of association to individual fragrance mix ingredients showed a significant association to alpha-amyl cinnamal and isoeugenol. CONCLUSIONS: The significant association between positive reactions to epoxy resin and fragrance mix I was reproduced. However, the clinical implications are not clarified, and even though the association may be coincidental, the fact that it can be reproduced with a different patch test system and in a different population speaks against a random result. Further studies may help to interpret the association.

U2 - 10.1111/j.1600-0536.2008.01498.x

DO - 10.1111/j.1600-0536.2008.01498.x

M3 - Journal article

VL - 60

SP - 155

EP - 157

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 3

ER -