Abstract
Purpose: To investigate the longitudinal associations between pain and depressive symptoms in adults. Methods: Prospective cohort study on data from 28,515 community-dwelling adults ≥ 50 years, free from depression at baseline (Wave 5), with follow-up in Wave 6 of the Survey of Health, Ageing and Retirement in Europe (SHARE). Significant depressive symptoms were defined by a EURO-D score ≥ 4. The longitudinal association between baseline pain intensity and significant depressive symptoms at follow-up was analysed using logistic regression models; odds ratios (ORs) and confidence intervals (CI) were calculated, adjusting for socio-demographic and clinical factors, physical inactivity, loneliness, mobility and functional impairments. Results: Mean age was 65.4 years (standard deviation 9.0, range 50–99); 14,360 (50.4%) participants were women. Mean follow-up was 23.4 (standard deviation 3.4) months. At baseline, 2803 (9.8%) participants reported mild pain, 5253 (18.4%) moderate pain and 1431 (5.0%) severe pain. At follow-up, 3868 (13.6%) participants—1451 (10.3%) men and 2417 (16.8%) women—reported significant depressive symptoms. After adjustment, mild, moderate and severe baseline pain, versus no pain, were associated with an increased likelihood of significant depressive symptoms at follow-up: ORs (95% CI) were 1.20 (1.06–1.35), 1.32 (1.20–1.46) and 1.39 (1.19–1.63), respectively. These associations were more pronounced in men compared to women, and consistent in participants aged 50–64 years, those without mobility or functional impairment, and those without loneliness at baseline. Conclusion: Higher baseline pain intensity was longitudinally associated with a greater risk of significant depressive symptoms at 2-year follow-up, in community-dwelling adults without baseline depression.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Geriatric Medicine |
| Vol/bind | 14 |
| Udgave nummer | 5 |
| Sider (fra-til) | 1111-1124 |
| ISSN | 1878-7649 |
| DOI | |
| Status | Udgivet - okt. 2023 |
Bibliografisk note
Funding Information:This paper uses data from SHARE Wave 5 and 6, release version: 8.0.0., as of 10th February 2022 ( https://doi.org/10.6103/SHARE.w5.800 and https://doi.org/10.6103/SHARE.w6.800 ), see Börsch-Supan et al. (2013) for methodological details [Borsch-Supan A, Brandt M, Hunkler C, et al. SHARE Central Coordination Team. Data Resource Profile: the Survey of Health, Ageing and Retirement in Europe (SHARE). Int J Epidemiol 2013;42:992–1001]. The SHARE data collection has been primarily funded by the European Commission through the fifth framework programme (project QLK6-CT-2001–00 360 in the thematic programme Quality of Life), through the sixth framework programme (projects SHARE-I3, RII-CT- 2006–0 62 193; COMPARE, CIT5-CT-2005–0 28 857; and SHARELIFE, CIT4-CT-2006–0 28 812) and through the seventh framework programme (SHARE-PREP, 2 11 909 and SHARE- LEAP, 227822). Additional funding from the US National Institute on Ageing (U01 AG09740-13S2, P01 AG005842, P01 AG08291, P30 AG12815, Y1-AG-4553–01 and OGHA 04–064, IAG BSR06-11, R21 AG025169) as well as from various national sources is gratefully acknowledged (see http://www.share-project.org/contact-organisation/funding.html for a full list of funding institutions). We presented preliminary findings on the cross-sectional association between pain intensity and presence of death wishes in 34,090 participants ≥65 years of Wave 6 of SHARE in the “Abstracts of the 18th Congress of the European Geriatric Medicine Society, Live from London and Online, 28–30 September 2022” as Poster 833 (P-833).