Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

Fredrik Olson, Jonathan Engborg, Mette H. Grønhøj, Niels P. Sand, Jess Lambrechtsen, Flemming Hald Steffensen, Mads Nybo, Oke Gerke, Hans Mickley, Axel C. P. Diederichsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population.

METHODS: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC).

RESULTS: Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001).

CONCLUSION: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.

OriginalsprogEngelsk
TidsskriftAtherosclerosis
Vol/bind245
Sider (fra-til)88-93
ISSN0021-9150
DOI
StatusUdgivet - feb. 2016

Fingeraftryk

Troponin I
Population
Immunoassay
ROC Curve
Limit of Detection
Logistic Models
Regression Analysis

Citer dette

@article{8237adc4b70c407e8f127b9dad79bd9e,
title = "Association between high-sensitive troponin I and coronary artery calcification in a Danish general population",
abstract = "BACKGROUND: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population.METHODS: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC).RESULTS: Concentrations of hs-TnI above the limit of detection were measured in 89.3{\%} of all subjects. Presence of CAC (Agatston score >0) was detected in 29{\%} in the lowest hs-TnI quartile compared with 55{\%} in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95{\%} CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95{\%} CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95{\%} CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95{\%} CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001).CONCLUSION: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.",
author = "Fredrik Olson and Jonathan Engborg and Gr{\o}nh{\o}j, {Mette H.} and Sand, {Niels P.} and Jess Lambrechtsen and {Hald Steffensen}, Flemming and Mads Nybo and Oke Gerke and Hans Mickley and Diederichsen, {Axel C. P.}",
note = "Copyright {\circledC} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = "2",
doi = "10.1016/j.atherosclerosis.2015.12.017",
language = "English",
volume = "245",
pages = "88--93",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",

}

Association between high-sensitive troponin I and coronary artery calcification in a Danish general population. / Olson, Fredrik; Engborg, Jonathan; Grønhøj, Mette H.; Sand, Niels P.; Lambrechtsen, Jess; Hald Steffensen, Flemming; Nybo, Mads; Gerke, Oke; Mickley, Hans; Diederichsen, Axel C. P.

I: Atherosclerosis, Bind 245, 02.2016, s. 88-93.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

AU - Olson, Fredrik

AU - Engborg, Jonathan

AU - Grønhøj, Mette H.

AU - Sand, Niels P.

AU - Lambrechtsen, Jess

AU - Hald Steffensen, Flemming

AU - Nybo, Mads

AU - Gerke, Oke

AU - Mickley, Hans

AU - Diederichsen, Axel C. P.

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population.METHODS: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC).RESULTS: Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001).CONCLUSION: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.

AB - BACKGROUND: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population.METHODS: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC).RESULTS: Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001).CONCLUSION: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.

U2 - 10.1016/j.atherosclerosis.2015.12.017

DO - 10.1016/j.atherosclerosis.2015.12.017

M3 - Journal article

C2 - 26714045

VL - 245

SP - 88

EP - 93

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -