Objective: To examine the association between the relaxation time (T1Gd) of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and grade of tibiofemoral joint space narrowing (JSN) and osteophytosis 11 years later, in a cohort of meniscectomized patients. Design: Patients (. n=45) aged 35-50 who had undergone an arthroscopic partial medial meniscectomy 1-6 years earlier, due to degenerative meniscal tear, were examined using dGEMRIC. These patients had no cartilage changes defined as deep clefts or visible bone at the time of arthroscopy. Eleven years later (12-16 years after surgery) 34 of these subjects (76%) were evaluated by weight-bearing knee radiography, and tibiofemoral joint changes were graded according to the Osteoarthritis Research Society International Atlas. Results: Lower T1Gd in the medial compartment was associated with higher grade of medial JSN (grade 0, 351ms; grade 1, 386ms; grade 2, 342ms; grade 3, 259ms [. P for trend<0.001]) and more osteophytosis (score 0, 371ms; score 1, 389ms; score 2, 354ms; score 3, 289ms; score 4, 265ms; score 5, 275ms [. P for trend=0.001]). Lower T1Gd in the lateral compartment was associated with higher grade of lateral JSN (grade 0, 436ms; grade 1, 346ms [. P for trend=0.026]). Conclusion: The current study suggests that lower T1Gd measured with dGEMRIC of medial and lateral femoral cartilage is associated with higher grade of JSN 11 years later, and medially, also with more osteophytosis.