Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietiläinen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos Cem van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria Antonietta Stazi, Corrado Fagnani, Cristina D'Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkilä, Tessa L CutlerJohn L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire Ma Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt McGue, Shandell Pahlen, Dorret I. Boomsma, Thorkild IA Sørensen, Jaakko Kaprio, Karri Silventoinen

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Resumé

Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.

Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.

Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m 2 higher BMI ( P  < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m 2 per kg birthweight, P  < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.

Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

OriginalsprogEngelsk
TidsskriftInternational Journal of Epidemiology
Vol/bind46
Udgave nummer5
Sider (fra-til)1488–1498
ISSN0300-5771
DOI
StatusUdgivet - okt. 2017

Fingeraftryk

Body Mass Index
Dizygotic Twins
Linear Models
Regression Analysis

Citer dette

Jelenkovic, Aline ; Yokoyama, Yoshie ; Sund, Reijo ; Pietiläinen, Kirsi H ; Hur, Yoon-Mi ; Willemsen, Gonneke ; Bartels, Meike ; van Beijsterveldt, Toos Cem ; Ooki, Syuichi ; Saudino, Kimberly J ; Stazi, Maria Antonietta ; Fagnani, Corrado ; D'Ippolito, Cristina ; Nelson, Tracy L ; Whitfield, Keith E ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Heikkilä, Kauko ; Cutler, Tessa L ; Hopper, John L ; Wardle, Jane ; Llewellyn, Clare H ; Fisher, Abigail ; Corley, Robin P ; Huibregtse, Brooke M ; Derom, Catherine A ; Vlietinck, Robert F ; Loos, Ruth Jf ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Tarnoki, Adam D ; Tarnoki, David L ; Burt, S Alexandra ; Klump, Kelly L ; Ordoñana, Juan R ; Sánchez-Romera, Juan F ; Colodro-Conde, Lucia ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Harris, Jennifer R ; Brandt, Ingunn ; Nilsen, Thomas Sevenius ; Craig, Jeffrey M ; Saffery, Richard ; Rasmussen, Finn ; Tynelius, Per ; Bayasgalan, Gombojav ; Narandalai, Danshiitsoodol ; Haworth, Claire Ma ; Plomin, Robert ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Rebato, Esther ; Krueger, Robert F ; McGue, Matt ; Pahlen, Shandell ; Boomsma, Dorret I. ; Sørensen, Thorkild IA ; Kaprio, Jaakko ; Silventoinen, Karri. / Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. I: International Journal of Epidemiology. 2017 ; Bind 46, Nr. 5. s. 1488–1498.
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title = "Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project",
abstract = "Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m 2 higher BMI ( P  < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m 2 per kg birthweight, P  < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.",
keywords = "Birthweight, Body mass index, Twins",
author = "Aline Jelenkovic and Yoshie Yokoyama and Reijo Sund and Pietil{\"a}inen, {Kirsi H} and Yoon-Mi Hur and Gonneke Willemsen and Meike Bartels and {van Beijsterveldt}, {Toos Cem} and Syuichi Ooki and Saudino, {Kimberly J} and Stazi, {Maria Antonietta} and Corrado Fagnani and Cristina D'Ippolito and Nelson, {Tracy L} and Whitfield, {Keith E} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Kauko Heikkil{\"a} and Cutler, {Tessa L} and Hopper, {John L} and Jane Wardle and Llewellyn, {Clare H} and Abigail Fisher and Corley, {Robin P} and Huibregtse, {Brooke M} and Derom, {Catherine A} and Vlietinck, {Robert F} and Loos, {Ruth Jf} and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Tarnoki, {Adam D} and Tarnoki, {David L} and Burt, {S Alexandra} and Klump, {Kelly L} and Ordo{\~n}ana, {Juan R} and S{\'a}nchez-Romera, {Juan F} and Lucia Colodro-Conde and Lise Dubois and Michel Boivin and Mara Brendgen and Ginette Dionne and Frank Vitaro and Harris, {Jennifer R} and Ingunn Brandt and Nilsen, {Thomas Sevenius} and Craig, {Jeffrey M} and Richard Saffery and Finn Rasmussen and Per Tynelius and Gombojav Bayasgalan and Danshiitsoodol Narandalai and Haworth, {Claire Ma} and Robert Plomin and Fuling Ji and Feng Ning and Zengchang Pang and Esther Rebato and Krueger, {Robert F} and Matt McGue and Shandell Pahlen and Boomsma, {Dorret I.} and S{\o}rensen, {Thorkild IA} and Jaakko Kaprio and Karri Silventoinen",
year = "2017",
month = "10",
doi = "10.1093/ije/dyx031",
language = "English",
volume = "46",
pages = "1488–1498",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Heinemann",
number = "5",

}

Jelenkovic, A, Yokoyama, Y, Sund, R, Pietiläinen, KH, Hur, Y-M, Willemsen, G, Bartels, M, van Beijsterveldt, TC, Ooki, S, Saudino, KJ, Stazi, MA, Fagnani, C, D'Ippolito, C, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Heikkilä, K, Cutler, TL, Hopper, JL, Wardle, J, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJ, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Burt, SA, Klump, KL, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Bayasgalan, G, Narandalai, D, Haworth, CM, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Krueger, RF, McGue, M, Pahlen, S, Boomsma, DI, Sørensen, TIA, Kaprio, J & Silventoinen, K 2017, 'Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project', International Journal of Epidemiology, bind 46, nr. 5, s. 1488–1498. https://doi.org/10.1093/ije/dyx031

Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. / Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Pietiläinen, Kirsi H; Hur, Yoon-Mi; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Toos Cem; Ooki, Syuichi; Saudino, Kimberly J; Stazi, Maria Antonietta; Fagnani, Corrado; D'Ippolito, Cristina; Nelson, Tracy L; Whitfield, Keith E; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Heikkilä, Kauko; Cutler, Tessa L; Hopper, John L; Wardle, Jane; Llewellyn, Clare H; Fisher, Abigail; Corley, Robin P; Huibregtse, Brooke M; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth Jf; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D; Tarnoki, David L; Burt, S Alexandra; Klump, Kelly L; Ordoñana, Juan R; Sánchez-Romera, Juan F; Colodro-Conde, Lucia; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Harris, Jennifer R; Brandt, Ingunn; Nilsen, Thomas Sevenius; Craig, Jeffrey M; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Haworth, Claire Ma; Plomin, Robert; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Boomsma, Dorret I.; Sørensen, Thorkild IA; Kaprio, Jaakko; Silventoinen, Karri.

I: International Journal of Epidemiology, Bind 46, Nr. 5, 10.2017, s. 1488–1498.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association between birthweight and later body mass index

T2 - an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

AU - Jelenkovic, Aline

AU - Yokoyama, Yoshie

AU - Sund, Reijo

AU - Pietiläinen, Kirsi H

AU - Hur, Yoon-Mi

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, Toos Cem

AU - Ooki, Syuichi

AU - Saudino, Kimberly J

AU - Stazi, Maria Antonietta

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Heikkilä, Kauko

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth Jf

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Harris, Jennifer R

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Rasmussen, Finn

AU - Tynelius, Per

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Haworth, Claire Ma

AU - Plomin, Robert

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Rebato, Esther

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Boomsma, Dorret I.

AU - Sørensen, Thorkild IA

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2017/10

Y1 - 2017/10

N2 - Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m 2 higher BMI ( P  < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m 2 per kg birthweight, P  < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

AB - Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m 2 higher BMI ( P  < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m 2 per kg birthweight, P  < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

KW - Birthweight

KW - Body mass index

KW - Twins

U2 - 10.1093/ije/dyx031

DO - 10.1093/ije/dyx031

M3 - Journal article

C2 - 28369451

VL - 46

SP - 1488

EP - 1498

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 5

ER -