Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta

Leila S Arani, Mohammad H Gharavi, Mahdi Z Zadeh, William Y Raynor, Siavash M Seraj, Caius M Constantinescu, Oke Gerke, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi

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Abstrakt

Objective: We aimed to assess the feasibility of quantifying fluorine-18-?fluorodexoglucose ( 18F-FDG) and 18F-sodium fluoride ( 18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. Subjects and Methods: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749). All subjects underwent 18F-FDG positron emis- sion tomography/computed tomography (PET/CT) and 18F-NaF PET/CT on separate days, 180min and 90 min after administration of tracers, respectively. The global tracer uptake value (GTUV) in the abdominal aorta was determined as sum of the product of each slice area and its corresponding average standardized uptake value (SUV mean), divided by the sum of those slice areas. In addition, for each subject, the 10 years Framingham risk score (FRS) was calculated. The correlations between 18F-NaF and 18F-FDG GTUV with age and 10 years FRS were assessed in all, healthy and patient subjects. Results: There was a significant, positive correlation between subjects' age and 18F-NaF GTUV (r=0.35, P<0.001), but not 18F-FDG GTUV (r=0.06, P= 0.53). Also, there was a significant, positive correlation between 10 years FRS and 18F-NaF GTUV (r=0.30, P< 0.001), but not 18F-FDG GTUV (r=0.01, P=0.95). Individual differences in 18F-FDG and 18F-NaF uptake were lar- ge in both healthy subjects and patients. Conclusion: In this study, the global uptake of 18F-NaF in abdominal aorta was positively associated with age and 10 years FRS in all subjects, healthy and patient groups, whereas the global uptake of 18F-FDG was not.

OriginalsprogEngelsk
TidsskriftHellenic Journal of Nuclear Medicine
Vol/bind22
Udgave nummer1
Sider (fra-til)14-19
ISSN1790-5427
DOI
StatusUdgivet - 8. mar. 2019

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