Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta

Leila S Arani, Mohammad H Gharavi, Mahdi Z Zadeh, William Y Raynor, Siavash M Seraj, Caius M Constantinescu, Oke Gerke, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: We aimed to assess the feasibility of quantifying fluorine-18-?fluorodexoglucose ( 18F-FDG) and 18F-sodium fluoride ( 18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. Subjects and Methods: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749). All subjects underwent 18F-FDG positron emis- sion tomography/computed tomography (PET/CT) and 18F-NaF PET/CT on separate days, 180min and 90 min after administration of tracers, respectively. The global tracer uptake value (GTUV) in the abdominal aorta was determined as sum of the product of each slice area and its corresponding average standardized uptake value (SUV mean), divided by the sum of those slice areas. In addition, for each subject, the 10 years Framingham risk score (FRS) was calculated. The correlations between 18F-NaF and 18F-FDG GTUV with age and 10 years FRS were assessed in all, healthy and patient subjects. Results: There was a significant, positive correlation between subjects' age and 18F-NaF GTUV (r=0.35, P<0.001), but not 18F-FDG GTUV (r=0.06, P= 0.53). Also, there was a significant, positive correlation between 10 years FRS and 18F-NaF GTUV (r=0.30, P< 0.001), but not 18F-FDG GTUV (r=0.01, P=0.95). Individual differences in 18F-FDG and 18F-NaF uptake were lar- ge in both healthy subjects and patients. Conclusion: In this study, the global uptake of 18F-NaF in abdominal aorta was positively associated with age and 10 years FRS in all subjects, healthy and patient groups, whereas the global uptake of 18F-FDG was not.

OriginalsprogEngelsk
TidsskriftHellenic Journal of Nuclear Medicine
Vol/bind22
Udgave nummer1
Sider (fra-til)14-19
ISSN1790-5427
DOI
StatusUdgivet - 8. mar. 2019

Fingeraftryk

Fluorodeoxyglucose F18
Fluorine
Denmark
Individuality

Citer dette

Arani, Leila S ; Gharavi, Mohammad H ; Zadeh, Mahdi Z ; Raynor, William Y ; Seraj, Siavash M ; Constantinescu, Caius M ; Gerke, Oke ; Werner, Thomas J ; Høilund-Carlsen, Poul F ; Alavi, Abass. / Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta. I: Hellenic Journal of Nuclear Medicine. 2019 ; Bind 22, Nr. 1. s. 14-19.
@article{d55742600d8c48d4afcec0dc6e8ab381,
title = "Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta",
abstract = "Objective: We aimed to assess the feasibility of quantifying fluorine-18-?fluorodexoglucose ( 18F-FDG) and 18F-sodium fluoride ( 18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. Subjects and Methods: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749). All subjects underwent 18F-FDG positron emis- sion tomography/computed tomography (PET/CT) and 18F-NaF PET/CT on separate days, 180min and 90 min after administration of tracers, respectively. The global tracer uptake value (GTUV) in the abdominal aorta was determined as sum of the product of each slice area and its corresponding average standardized uptake value (SUV mean), divided by the sum of those slice areas. In addition, for each subject, the 10 years Framingham risk score (FRS) was calculated. The correlations between 18F-NaF and 18F-FDG GTUV with age and 10 years FRS were assessed in all, healthy and patient subjects. Results: There was a significant, positive correlation between subjects' age and 18F-NaF GTUV (r=0.35, P<0.001), but not 18F-FDG GTUV (r=0.06, P= 0.53). Also, there was a significant, positive correlation between 10 years FRS and 18F-NaF GTUV (r=0.30, P< 0.001), but not 18F-FDG GTUV (r=0.01, P=0.95). Individual differences in 18F-FDG and 18F-NaF uptake were lar- ge in both healthy subjects and patients. Conclusion: In this study, the global uptake of 18F-NaF in abdominal aorta was positively associated with age and 10 years FRS in all subjects, healthy and patient groups, whereas the global uptake of 18F-FDG was not.",
keywords = "Arterial calcification, Arterial inflammation, Atherosclerosis, Fluorine-18-FDG, Positron emission tomography, Sodium fluorine-18",
author = "Arani, {Leila S} and Gharavi, {Mohammad H} and Zadeh, {Mahdi Z} and Raynor, {William Y} and Seraj, {Siavash M} and Constantinescu, {Caius M} and Oke Gerke and Werner, {Thomas J} and H{\o}ilund-Carlsen, {Poul F} and Abass Alavi",
year = "2019",
month = "3",
day = "8",
doi = "10.1967/s002449910954",
language = "English",
volume = "22",
pages = "14--19",
journal = "Hellenic Journal of Nuclear Medicine",
issn = "1108-1430",
publisher = "Hellenic Society of Nuclear Medicine",
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}

Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta. / Arani, Leila S; Gharavi, Mohammad H; Zadeh, Mahdi Z; Raynor, William Y; Seraj, Siavash M; Constantinescu, Caius M; Gerke, Oke; Werner, Thomas J; Høilund-Carlsen, Poul F; Alavi, Abass.

I: Hellenic Journal of Nuclear Medicine, Bind 22, Nr. 1, 08.03.2019, s. 14-19.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta

AU - Arani, Leila S

AU - Gharavi, Mohammad H

AU - Zadeh, Mahdi Z

AU - Raynor, William Y

AU - Seraj, Siavash M

AU - Constantinescu, Caius M

AU - Gerke, Oke

AU - Werner, Thomas J

AU - Høilund-Carlsen, Poul F

AU - Alavi, Abass

PY - 2019/3/8

Y1 - 2019/3/8

N2 - Objective: We aimed to assess the feasibility of quantifying fluorine-18-?fluorodexoglucose ( 18F-FDG) and 18F-sodium fluoride ( 18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. Subjects and Methods: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749). All subjects underwent 18F-FDG positron emis- sion tomography/computed tomography (PET/CT) and 18F-NaF PET/CT on separate days, 180min and 90 min after administration of tracers, respectively. The global tracer uptake value (GTUV) in the abdominal aorta was determined as sum of the product of each slice area and its corresponding average standardized uptake value (SUV mean), divided by the sum of those slice areas. In addition, for each subject, the 10 years Framingham risk score (FRS) was calculated. The correlations between 18F-NaF and 18F-FDG GTUV with age and 10 years FRS were assessed in all, healthy and patient subjects. Results: There was a significant, positive correlation between subjects' age and 18F-NaF GTUV (r=0.35, P<0.001), but not 18F-FDG GTUV (r=0.06, P= 0.53). Also, there was a significant, positive correlation between 10 years FRS and 18F-NaF GTUV (r=0.30, P< 0.001), but not 18F-FDG GTUV (r=0.01, P=0.95). Individual differences in 18F-FDG and 18F-NaF uptake were lar- ge in both healthy subjects and patients. Conclusion: In this study, the global uptake of 18F-NaF in abdominal aorta was positively associated with age and 10 years FRS in all subjects, healthy and patient groups, whereas the global uptake of 18F-FDG was not.

AB - Objective: We aimed to assess the feasibility of quantifying fluorine-18-?fluorodexoglucose ( 18F-FDG) and 18F-sodium fluoride ( 18F-NaF) uptake in abdominal aorta and examine their association with age and cardiovascular risk factors. Subjects and Methods: Our study comprised 123 subjects (48±14 years of age, 62 men) including 78 healthy volunteers and 45 patients with chest pain syndrome, who originally enrolled in the CAMONA study in Odense, Denmark (NCT01724749). All subjects underwent 18F-FDG positron emis- sion tomography/computed tomography (PET/CT) and 18F-NaF PET/CT on separate days, 180min and 90 min after administration of tracers, respectively. The global tracer uptake value (GTUV) in the abdominal aorta was determined as sum of the product of each slice area and its corresponding average standardized uptake value (SUV mean), divided by the sum of those slice areas. In addition, for each subject, the 10 years Framingham risk score (FRS) was calculated. The correlations between 18F-NaF and 18F-FDG GTUV with age and 10 years FRS were assessed in all, healthy and patient subjects. Results: There was a significant, positive correlation between subjects' age and 18F-NaF GTUV (r=0.35, P<0.001), but not 18F-FDG GTUV (r=0.06, P= 0.53). Also, there was a significant, positive correlation between 10 years FRS and 18F-NaF GTUV (r=0.30, P< 0.001), but not 18F-FDG GTUV (r=0.01, P=0.95). Individual differences in 18F-FDG and 18F-NaF uptake were lar- ge in both healthy subjects and patients. Conclusion: In this study, the global uptake of 18F-NaF in abdominal aorta was positively associated with age and 10 years FRS in all subjects, healthy and patient groups, whereas the global uptake of 18F-FDG was not.

KW - Arterial calcification

KW - Arterial inflammation

KW - Atherosclerosis

KW - Fluorine-18-FDG

KW - Positron emission tomography

KW - Sodium fluorine-18

U2 - 10.1967/s002449910954

DO - 10.1967/s002449910954

M3 - Journal article

C2 - 30843005

VL - 22

SP - 14

EP - 19

JO - Hellenic Journal of Nuclear Medicine

JF - Hellenic Journal of Nuclear Medicine

SN - 1108-1430

IS - 1

ER -