Association and interaction analyses of eight genes under asthma linkage peaks

M A R Ferreira, Z Z Zhao, S F Thomsen, M James, D M Evans, P E Postmus, K O Kyvik, V Backer, D I Boomsma, N G Martin, G W Montgomery, D L Duffy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Nov
OriginalsprogEngelsk
TidsskriftAllergy. European Journal of Allergy and Clinical Immunology
Vol/bind64
Udgave nummer11
Sider (fra-til)1623-8
Antal sider5
ISSN0105-4538
DOI
StatusUdgivet - 1. nov. 2009

Fingeraftryk

Gene-Environment Interaction
Eosinophilia
Airway Obstruction
Single Nucleotide Polymorphism
Serum

Citer dette

Ferreira, M. A. R., Zhao, Z. Z., Thomsen, S. F., James, M., Evans, D. M., Postmus, P. E., ... Duffy, D. L. (2009). Association and interaction analyses of eight genes under asthma linkage peaks. Allergy. European Journal of Allergy and Clinical Immunology, 64(11), 1623-8. https://doi.org/10.1111/j.1398-9995.2009.02091.x
Ferreira, M A R ; Zhao, Z Z ; Thomsen, S F ; James, M ; Evans, D M ; Postmus, P E ; Kyvik, K O ; Backer, V ; Boomsma, D I ; Martin, N G ; Montgomery, G W ; Duffy, D L. / Association and interaction analyses of eight genes under asthma linkage peaks. I: Allergy. European Journal of Allergy and Clinical Immunology. 2009 ; Bind 64, Nr. 11. s. 1623-8.
@article{9d687d90f9f811deaefb000ea68e967b,
title = "Association and interaction analyses of eight genes under asthma linkage peaks",
abstract = "BACKGROUND: Linkage studies have implicated the 2q33, 9p21, 11q13 and 20q13 regions in the regulation of allergic disease. The aim of this study was to test genetic variants in candidate genes from these regions for association with specific asthma traits. METHODS: Ninety-five single nucleotide polymorphisms (SNP) located in eight genes (CD28, CTLA4, ICOS, ADAM23, ADAMTSL1, MS4A2, CDH26 and HRH3) were genotyped in >5000 individuals from Australian (n = 1162), Dutch (n = 99) and Danish (n = 303) families. Traits tested included doctor-diagnosed asthma, atopy, airway obstruction, total serum immunoglobulin (Ig) E levels and eosinophilia. Association was tested using both multivariate and univariate methods, with gene-wide thresholds for significance determined through simulation. Gene-by-gene and gene-by-environment analyses were also performed. RESULTS: There was no overall evidence for association with seven of the eight genes tested when considering all genetic variation assayed in each gene. The exception was MS4A2 on chromosome 11q13, which showed weak evidence for association with IgE (gene-wide P < 0.05, rs502581). There were no significant gene-by-gene or gene-by-environment interaction effects after accounting for the number of tests performed. CONCLUSIONS: The individual variants genotyped in the 2q33, 9p21 and 20q13 regions do not explain a large fraction of the variation in the quantitative traits tested or have a major impact on asthma or atopy risk. Our results are consistent with a weak effect of MS4A2 polymorphisms on the variation of total IgE levels.",
author = "Ferreira, {M A R} and Zhao, {Z Z} and Thomsen, {S F} and M James and Evans, {D M} and Postmus, {P E} and Kyvik, {K O} and V Backer and Boomsma, {D I} and Martin, {N G} and Montgomery, {G W} and Duffy, {D L}",
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month = "11",
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Ferreira, MAR, Zhao, ZZ, Thomsen, SF, James, M, Evans, DM, Postmus, PE, Kyvik, KO, Backer, V, Boomsma, DI, Martin, NG, Montgomery, GW & Duffy, DL 2009, 'Association and interaction analyses of eight genes under asthma linkage peaks', Allergy. European Journal of Allergy and Clinical Immunology, bind 64, nr. 11, s. 1623-8. https://doi.org/10.1111/j.1398-9995.2009.02091.x

Association and interaction analyses of eight genes under asthma linkage peaks. / Ferreira, M A R; Zhao, Z Z; Thomsen, S F; James, M; Evans, D M; Postmus, P E; Kyvik, K O; Backer, V; Boomsma, D I; Martin, N G; Montgomery, G W; Duffy, D L.

I: Allergy. European Journal of Allergy and Clinical Immunology, Bind 64, Nr. 11, 01.11.2009, s. 1623-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Association and interaction analyses of eight genes under asthma linkage peaks

AU - Ferreira, M A R

AU - Zhao, Z Z

AU - Thomsen, S F

AU - James, M

AU - Evans, D M

AU - Postmus, P E

AU - Kyvik, K O

AU - Backer, V

AU - Boomsma, D I

AU - Martin, N G

AU - Montgomery, G W

AU - Duffy, D L

PY - 2009/11/1

Y1 - 2009/11/1

N2 - BACKGROUND: Linkage studies have implicated the 2q33, 9p21, 11q13 and 20q13 regions in the regulation of allergic disease. The aim of this study was to test genetic variants in candidate genes from these regions for association with specific asthma traits. METHODS: Ninety-five single nucleotide polymorphisms (SNP) located in eight genes (CD28, CTLA4, ICOS, ADAM23, ADAMTSL1, MS4A2, CDH26 and HRH3) were genotyped in >5000 individuals from Australian (n = 1162), Dutch (n = 99) and Danish (n = 303) families. Traits tested included doctor-diagnosed asthma, atopy, airway obstruction, total serum immunoglobulin (Ig) E levels and eosinophilia. Association was tested using both multivariate and univariate methods, with gene-wide thresholds for significance determined through simulation. Gene-by-gene and gene-by-environment analyses were also performed. RESULTS: There was no overall evidence for association with seven of the eight genes tested when considering all genetic variation assayed in each gene. The exception was MS4A2 on chromosome 11q13, which showed weak evidence for association with IgE (gene-wide P < 0.05, rs502581). There were no significant gene-by-gene or gene-by-environment interaction effects after accounting for the number of tests performed. CONCLUSIONS: The individual variants genotyped in the 2q33, 9p21 and 20q13 regions do not explain a large fraction of the variation in the quantitative traits tested or have a major impact on asthma or atopy risk. Our results are consistent with a weak effect of MS4A2 polymorphisms on the variation of total IgE levels.

AB - BACKGROUND: Linkage studies have implicated the 2q33, 9p21, 11q13 and 20q13 regions in the regulation of allergic disease. The aim of this study was to test genetic variants in candidate genes from these regions for association with specific asthma traits. METHODS: Ninety-five single nucleotide polymorphisms (SNP) located in eight genes (CD28, CTLA4, ICOS, ADAM23, ADAMTSL1, MS4A2, CDH26 and HRH3) were genotyped in >5000 individuals from Australian (n = 1162), Dutch (n = 99) and Danish (n = 303) families. Traits tested included doctor-diagnosed asthma, atopy, airway obstruction, total serum immunoglobulin (Ig) E levels and eosinophilia. Association was tested using both multivariate and univariate methods, with gene-wide thresholds for significance determined through simulation. Gene-by-gene and gene-by-environment analyses were also performed. RESULTS: There was no overall evidence for association with seven of the eight genes tested when considering all genetic variation assayed in each gene. The exception was MS4A2 on chromosome 11q13, which showed weak evidence for association with IgE (gene-wide P < 0.05, rs502581). There were no significant gene-by-gene or gene-by-environment interaction effects after accounting for the number of tests performed. CONCLUSIONS: The individual variants genotyped in the 2q33, 9p21 and 20q13 regions do not explain a large fraction of the variation in the quantitative traits tested or have a major impact on asthma or atopy risk. Our results are consistent with a weak effect of MS4A2 polymorphisms on the variation of total IgE levels.

U2 - 10.1111/j.1398-9995.2009.02091.x

DO - 10.1111/j.1398-9995.2009.02091.x

M3 - Journal article

VL - 64

SP - 1623

EP - 1628

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 11

ER -