Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18F-NaF PET/CT.

Abdullah Al-Zaghal, Siavash Mehdizadeh Seraj, Thomas J. Werner, Oke Gerke, Poul F. Høilund-Carlsen, Abass Alavi*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The aim of this research study was to determine the role of 18F-sodium fluoride (18F-NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intracranial structures. We also examined the association of 18F-NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomic sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18F-NaF PET/CT (CAMONA) clinical trial (38 women and 40 men) were included in this retrospective study. The mean age was 45.28 ± 14.15 y (age range, 21–75 y). SUVmean was used to measure 18F-NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each region of interest. Correlation analysis was conducted to assess the association between parameters. Results: Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ± 25 in the left choroid plexus, and 0.23 ± 0.08 in the epithalamus. Significant positive correlations were present between 18F-NaF uptake and age in the right choroid plexus (r 5 0.61, P, 0.0001), left choroid plexus (r 5 0.63, P, 0.0001), and epithalamus (r 5 0.36, P 5 0.001). 18F-NaF uptake significantly correlated with HU in the right choroid plexus (r 5 0.52, P, 0.0001), left choroid plexus (r 5 0.57, P, 0.0001), and epithalamus (r 5 0.25, P 5 0.03). Conclusion: 18F-NaF could be used in the assessment of physiologic calcification in several intracranial structures. We report significant associations between 18F-NaF uptake and aging as well as HU in the calcified choroid plexus and epithalamus. Our findings further support the growing interest to use 18F-NaF for detecting extraosseous, molecular calcification, and this powerful probe has potential applications in the evaluation of various age-related, neurodegenerative brain processes.

OriginalsprogEngelsk
TidsskriftJournal of Nuclear Medicine
Vol/bind60
Udgave nummer2
Sider (fra-til)267-271
ISSN0161-5505
DOI
StatusUdgivet - feb. 2019

Fingeraftryk

Choroid Plexus
Habenula
Pineal Gland
Retrospective Studies
Clinical Trials
Research

Citer dette

Al-Zaghal, Abdullah ; Seraj, Siavash Mehdizadeh ; Werner, Thomas J. ; Gerke, Oke ; Høilund-Carlsen, Poul F. ; Alavi, Abass. / Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18F-NaF PET/CT. I: Journal of Nuclear Medicine. 2019 ; Bind 60, Nr. 2. s. 267-271.
@article{c6c4abcdbf274fde8cfdb69801b735fa,
title = "Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18F-NaF PET/CT.",
abstract = "The aim of this research study was to determine the role of 18F-sodium fluoride (18F-NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intracranial structures. We also examined the association of 18F-NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomic sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18F-NaF PET/CT (CAMONA) clinical trial (38 women and 40 men) were included in this retrospective study. The mean age was 45.28 ± 14.15 y (age range, 21–75 y). SUVmean was used to measure 18F-NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each region of interest. Correlation analysis was conducted to assess the association between parameters. Results: Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ± 25 in the left choroid plexus, and 0.23 ± 0.08 in the epithalamus. Significant positive correlations were present between 18F-NaF uptake and age in the right choroid plexus (r 5 0.61, P, 0.0001), left choroid plexus (r 5 0.63, P, 0.0001), and epithalamus (r 5 0.36, P 5 0.001). 18F-NaF uptake significantly correlated with HU in the right choroid plexus (r 5 0.52, P, 0.0001), left choroid plexus (r 5 0.57, P, 0.0001), and epithalamus (r 5 0.25, P 5 0.03). Conclusion: 18F-NaF could be used in the assessment of physiologic calcification in several intracranial structures. We report significant associations between 18F-NaF uptake and aging as well as HU in the calcified choroid plexus and epithalamus. Our findings further support the growing interest to use 18F-NaF for detecting extraosseous, molecular calcification, and this powerful probe has potential applications in the evaluation of various age-related, neurodegenerative brain processes.",
keywords = "Brain calcification, Choroid plexus, NaF, PET, Pineal gland",
author = "Abdullah Al-Zaghal and Seraj, {Siavash Mehdizadeh} and Werner, {Thomas J.} and Oke Gerke and H{\o}ilund-Carlsen, {Poul F.} and Abass Alavi",
year = "2019",
month = "2",
doi = "10.2967/jnumed.118.213678",
language = "English",
volume = "60",
pages = "267--271",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "2",

}

Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18F-NaF PET/CT. / Al-Zaghal, Abdullah; Seraj, Siavash Mehdizadeh; Werner, Thomas J.; Gerke, Oke; Høilund-Carlsen, Poul F.; Alavi, Abass.

I: Journal of Nuclear Medicine, Bind 60, Nr. 2, 02.2019, s. 267-271.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Assessment of Physiological Intracranial Calcification in Healthy Adults Using 18F-NaF PET/CT.

AU - Al-Zaghal, Abdullah

AU - Seraj, Siavash Mehdizadeh

AU - Werner, Thomas J.

AU - Gerke, Oke

AU - Høilund-Carlsen, Poul F.

AU - Alavi, Abass

PY - 2019/2

Y1 - 2019/2

N2 - The aim of this research study was to determine the role of 18F-sodium fluoride (18F-NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intracranial structures. We also examined the association of 18F-NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomic sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18F-NaF PET/CT (CAMONA) clinical trial (38 women and 40 men) were included in this retrospective study. The mean age was 45.28 ± 14.15 y (age range, 21–75 y). SUVmean was used to measure 18F-NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each region of interest. Correlation analysis was conducted to assess the association between parameters. Results: Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ± 25 in the left choroid plexus, and 0.23 ± 0.08 in the epithalamus. Significant positive correlations were present between 18F-NaF uptake and age in the right choroid plexus (r 5 0.61, P, 0.0001), left choroid plexus (r 5 0.63, P, 0.0001), and epithalamus (r 5 0.36, P 5 0.001). 18F-NaF uptake significantly correlated with HU in the right choroid plexus (r 5 0.52, P, 0.0001), left choroid plexus (r 5 0.57, P, 0.0001), and epithalamus (r 5 0.25, P 5 0.03). Conclusion: 18F-NaF could be used in the assessment of physiologic calcification in several intracranial structures. We report significant associations between 18F-NaF uptake and aging as well as HU in the calcified choroid plexus and epithalamus. Our findings further support the growing interest to use 18F-NaF for detecting extraosseous, molecular calcification, and this powerful probe has potential applications in the evaluation of various age-related, neurodegenerative brain processes.

AB - The aim of this research study was to determine the role of 18F-sodium fluoride (18F-NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intracranial structures. We also examined the association of 18F-NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomic sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18F-NaF PET/CT (CAMONA) clinical trial (38 women and 40 men) were included in this retrospective study. The mean age was 45.28 ± 14.15 y (age range, 21–75 y). SUVmean was used to measure 18F-NaF accumulation in the choroid plexus and epithalamus (pineal gland and habenula). Maximum HU was also measured for each region of interest. Correlation analysis was conducted to assess the association between parameters. Results: Mean SUVmean was 0.42 ± 0.26 in the right choroid plexus, 0.39 ± 25 in the left choroid plexus, and 0.23 ± 0.08 in the epithalamus. Significant positive correlations were present between 18F-NaF uptake and age in the right choroid plexus (r 5 0.61, P, 0.0001), left choroid plexus (r 5 0.63, P, 0.0001), and epithalamus (r 5 0.36, P 5 0.001). 18F-NaF uptake significantly correlated with HU in the right choroid plexus (r 5 0.52, P, 0.0001), left choroid plexus (r 5 0.57, P, 0.0001), and epithalamus (r 5 0.25, P 5 0.03). Conclusion: 18F-NaF could be used in the assessment of physiologic calcification in several intracranial structures. We report significant associations between 18F-NaF uptake and aging as well as HU in the calcified choroid plexus and epithalamus. Our findings further support the growing interest to use 18F-NaF for detecting extraosseous, molecular calcification, and this powerful probe has potential applications in the evaluation of various age-related, neurodegenerative brain processes.

KW - Brain calcification

KW - Choroid plexus

KW - NaF

KW - PET

KW - Pineal gland

U2 - 10.2967/jnumed.118.213678

DO - 10.2967/jnumed.118.213678

M3 - Journal article

VL - 60

SP - 267

EP - 271

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 2

ER -