Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes

Birgitte Bytoft, Sine Knorr, Zuzana Vlachova, Rikke B Jensen, Elisabeth R Mathiesen, Henning Beck-Nielsen, Claus H Gravholt, Dorte M Jensen, Tine D Clausen, Erik L Mortensen, Peter Damm

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

151 Downloads (Pure)

Resumé

OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.

RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.

RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.

CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.

OriginalsprogEngelsk
Artikelnummere0169308
TidsskriftPLOS ONE
Vol/bind12
Udgave nummer1
Antal sider13
ISSN1932-6203
DOI
StatusUdgivet - 2017

Fingeraftryk

insulin-dependent diabetes mellitus
Medical problems
Mothers
drug therapy
diabetes
testing
Maternal Exposure
principal component analysis
Principal component analysis
Control Groups
Impulsive Behavior

Citer dette

Bytoft, B., Knorr, S., Vlachova, Z., Jensen, R. B., Mathiesen, E. R., Beck-Nielsen, H., ... Damm, P. (2017). Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes. PLOS ONE, 12(1), [e0169308]. https://doi.org/10.1371/journal.pone.0169308
Bytoft, Birgitte ; Knorr, Sine ; Vlachova, Zuzana ; Jensen, Rikke B ; Mathiesen, Elisabeth R ; Beck-Nielsen, Henning ; Gravholt, Claus H ; Jensen, Dorte M ; Clausen, Tine D ; Mortensen, Erik L ; Damm, Peter. / Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes. I: PLOS ONE. 2017 ; Bind 12, Nr. 1.
@article{159cc736570b4cfc9331e4892edd37a7,
title = "Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes",
abstract = "OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2{\%} vs. 0.0{\%}, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.",
author = "Birgitte Bytoft and Sine Knorr and Zuzana Vlachova and Jensen, {Rikke B} and Mathiesen, {Elisabeth R} and Henning Beck-Nielsen and Gravholt, {Claus H} and Jensen, {Dorte M} and Clausen, {Tine D} and Mortensen, {Erik L} and Peter Damm",
year = "2017",
doi = "10.1371/journal.pone.0169308",
language = "English",
volume = "12",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

Bytoft, B, Knorr, S, Vlachova, Z, Jensen, RB, Mathiesen, ER, Beck-Nielsen, H, Gravholt, CH, Jensen, DM, Clausen, TD, Mortensen, EL & Damm, P 2017, 'Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes', PLOS ONE, bind 12, nr. 1, e0169308. https://doi.org/10.1371/journal.pone.0169308

Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes. / Bytoft, Birgitte; Knorr, Sine; Vlachova, Zuzana; Jensen, Rikke B; Mathiesen, Elisabeth R; Beck-Nielsen, Henning; Gravholt, Claus H; Jensen, Dorte M; Clausen, Tine D; Mortensen, Erik L; Damm, Peter.

I: PLOS ONE, Bind 12, Nr. 1, e0169308, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes

AU - Bytoft, Birgitte

AU - Knorr, Sine

AU - Vlachova, Zuzana

AU - Jensen, Rikke B

AU - Mathiesen, Elisabeth R

AU - Beck-Nielsen, Henning

AU - Gravholt, Claus H

AU - Jensen, Dorte M

AU - Clausen, Tine D

AU - Mortensen, Erik L

AU - Damm, Peter

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.

AB - OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.RESULTS: A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.CONCLUSIONS: Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test.

U2 - 10.1371/journal.pone.0169308

DO - 10.1371/journal.pone.0169308

M3 - Journal article

C2 - 28072839

VL - 12

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 1

M1 - e0169308

ER -