TY - JOUR
T1 - Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18F- sodium fluoride PET/CT
AU - Arani, Leila S.
AU - Zirakchian Zadeh, Mahdi
AU - Saboury, Babak
AU - Revheim, Mona Elisabeth
AU - Øestergaard, Brian
AU - Borja, Austin J.
AU - Samadi Samarin, Davoud
AU - Mehdizadeh Seraj, Siavash
AU - Kalbush, Eman
AU - Ayubcha, Cyrus
AU - Morris, Michael A.
AU - Werner, Tom J.
AU - Abildgaard, Niels
AU - Høilund-Carlsen, Poul F.
AU - Alavi, Abass
N1 - Funding Information:
The project was funded by the Region of Southern Denmark, University of Southern Denmark, Odense University Hospital, Harboe Foundation, The A.P.Møller Foundation (Fonden til lægevidenskabens fremme), Aase & Ejnar Danielsen Foundation, The Family Hede Nielsen Foundation.
Publisher Copyright:
© 2021, American Society of Nuclear Cardiology.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/3
Y1 - 2021/1/3
N2 - Background: To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Methods: Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual’s NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR). Results: There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001). Conclusions: We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.
AB - Background: To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Methods: Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual’s NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR). Results: There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001). Conclusions: We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.
KW - F-NaF
KW - atherosclerosis
KW - multiple myeloma
KW - Positron emission tomography
KW - smoldering myeloma
KW - thoracic aorta
U2 - 10.1007/s12350-020-02446-0
DO - 10.1007/s12350-020-02446-0
M3 - Journal article
C2 - 33389640
AN - SCOPUS:85098569279
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
ER -