Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18F- sodium fluoride PET/CT

Leila S. Arani, Mahdi Zirakchian Zadeh, Babak Saboury, Mona Elisabeth Revheim, Brian Øestergaard, Austin J. Borja, Davoud Samadi Samarin, Siavash Mehdizadeh Seraj, Eman Kalbush, Cyrus Ayubcha, Michael A. Morris, Tom J. Werner, Niels Abildgaard, Poul F. Høilund-Carlsen, Abass Alavi*

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Abstrakt

Background: To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Methods: Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual’s NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR). Results: There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001). Conclusions: We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.

OriginalsprogEngelsk
TidsskriftJournal of Nuclear Cardiology
ISSN1071-3581
DOI
StatusE-pub ahead of print - 3. jan. 2021

Bibliografisk note

Funding Information:
The project was funded by the Region of Southern Denmark, University of Southern Denmark, Odense University Hospital, Harboe Foundation, The A.P.Møller Foundation (Fonden til lægevidenskabens fremme), Aase & Ejnar Danielsen Foundation, The Family Hede Nielsen Foundation.

Publisher Copyright:
© 2021, American Society of Nuclear Cardiology.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

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