Assessing the feasibility of NaF-PET/CT versus FDG-PET/CT to detect abdominal aortic calcification or inflammation in rheumatoid arthritis patients

Siavash Mehdizadeh Seraj, William Y Raynor, Mona-Elisabeth Revheim, Abdullah Al-Zaghal, Mahdi Zirakchian Zadeh, Leila S Arani, Chaitanya Rojulpote, Thomas J Werner, Oke Gerke, Poul F Høilund-Carlsen, Joshua F Baker, Abass Alavi, Stephen J Hunt

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Abstrakt

OBJECTIVE: We aimed to determine whether NaF-PET/CT or FDG-PET/CT can detect abdominal aortic molecular calcification and inflammation in patients with rheumatoid arthritis (RA).

METHODS: In this study, 18 RA patients (4 women, 14 men; mean age 56.0 ± 11.7) and 18 healthy controls (4 women, 14 men; mean age 55.8 ± 11.9) were included. The controls were matched to patients by sex and age (± 4 years). All subjects of this study underwent NaF-PET/CT scanning 90 min following the administration of NaF. FDG-PET/CT imaging was performed 180 min following intravenous FDG injection. Using OsiriX software, the global mean standardized uptake value (global SUVmean) in abdominal aorta was calculated for both FDG and NaF. The NaF SUVmean and FDG SUVmean were divided by the blood pool activity providing target-to-background ratios (TBR) namely, NaF-TBRmean and FDG-TBRmean. The CT calcium volume score was obtained using a growing region algorithm based on Hounsfield units.

RESULTS: The average NaF-TBRmean score among RA patients was significantly greater than that of healthy controls (median 1.61; IQR 1.49-1.88 and median 1.40; IQR 1.23-1.52, P = 0.002). The average CT calcium volume score among RA patients was also significantly greater than that of healthy controls (median 1.96 cm3; IQR 0.57-5.48 and median 0.004 cm3; IQR 0.04-0.05, P < 0.001). There was no significant difference between the average FDG-TBRmean scores in the RA patients when compared to healthy controls (median 1.29; IQR 1.13-1.52 and median 1.29; IQR 1.13-1.52, respectively, P = 0.98).

CONCLUSION: Quantitative assessment with NaF-PET/CT identifies increased molecular calcification in the wall of the abdominal aorta among patients with RA as compared with healthy controls, while quantitative assessment with FDG-PET/CT did not identify a difference in aortic vessel wall FDG uptake between the RA and healthy control groups.

OriginalsprogEngelsk
TidsskriftAnnals of Nuclear Medicine
Vol/bind34
Udgave nummer6
Sider (fra-til)424-431
Antal sider8
ISSN0914-7187
DOI
StatusUdgivet - 28. maj 2020

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Citationsformater

Seraj, S. M., Raynor, W. Y., Revheim, M-E., Al-Zaghal, A., Zadeh, M. Z., Arani, L. S., Rojulpote, C., Werner, T. J., Gerke, O., Høilund-Carlsen, P. F., Baker, J. F., Alavi, A., & Hunt, S. J. (2020). Assessing the feasibility of NaF-PET/CT versus FDG-PET/CT to detect abdominal aortic calcification or inflammation in rheumatoid arthritis patients. Annals of Nuclear Medicine, 34(6), 424-431. https://doi.org/10.1007/s12149-020-01463-w