Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study

Mia Madsen, Per K Andersen, Mette Gerster, Anne-Marie N Andersen, Kaare Christensen, Merete Osler

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD. Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood environment and are matched partly or fully on genetic setup. The attenuation of association of education with CVD and IHD in the intra-pair analyses suggests that shared familial factors account for a substantial part of the observed association of education with CVD and IHD in Denmark.
OriginalsprogEngelsk
TidsskriftSocial Science & Medicine
Vol/bind118
Sider (fra-til)182-190
ISSN0277-9536
DOI
StatusUdgivet - 2014

Fingeraftryk

twin studies
Twin Studies
heart disease
incidence
Disease
Incidence
Education
Denmark
education
childhood
Registries
statistics
Cardiovascular Disease
Twin Study
Familial
Ischemic Heart Disease
event

Emneord

  • Cardiovascular diseases
  • Education
  • Social class
  • Twin Study

Citer dette

Madsen, Mia ; Andersen, Per K ; Gerster, Mette ; Andersen, Anne-Marie N ; Christensen, Kaare ; Osler, Merete. / Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study. I: Social Science & Medicine. 2014 ; Bind 118. s. 182-190.
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title = "Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors?: A twin study",
abstract = "To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD. Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood environment and are matched partly or fully on genetic setup. The attenuation of association of education with CVD and IHD in the intra-pair analyses suggests that shared familial factors account for a substantial part of the observed association of education with CVD and IHD in Denmark.",
keywords = "Cardiovascular diseases, Education, Social class, Twin Study",
author = "Mia Madsen and Andersen, {Per K} and Mette Gerster and Andersen, {Anne-Marie N} and Kaare Christensen and Merete Osler",
note = "Copyright {\circledC} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
doi = "10.1016/j.socscimed.2014.04.016",
language = "English",
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Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study. / Madsen, Mia; Andersen, Per K; Gerster, Mette; Andersen, Anne-Marie N; Christensen, Kaare; Osler, Merete.

I: Social Science & Medicine, Bind 118, 2014, s. 182-190.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors?

T2 - A twin study

AU - Madsen, Mia

AU - Andersen, Per K

AU - Gerster, Mette

AU - Andersen, Anne-Marie N

AU - Christensen, Kaare

AU - Osler, Merete

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014

Y1 - 2014

N2 - To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD. Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood environment and are matched partly or fully on genetic setup. The attenuation of association of education with CVD and IHD in the intra-pair analyses suggests that shared familial factors account for a substantial part of the observed association of education with CVD and IHD in Denmark.

AB - To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD. Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood environment and are matched partly or fully on genetic setup. The attenuation of association of education with CVD and IHD in the intra-pair analyses suggests that shared familial factors account for a substantial part of the observed association of education with CVD and IHD in Denmark.

KW - Cardiovascular diseases

KW - Education

KW - Social class

KW - Twin Study

U2 - 10.1016/j.socscimed.2014.04.016

DO - 10.1016/j.socscimed.2014.04.016

M3 - Journal article

C2 - 24768271

VL - 118

SP - 182

EP - 190

JO - Social Science & Medicine

JF - Social Science & Medicine

SN - 0277-9536

ER -