Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation?

Linda Kaerlev, Henrik Kolstad, Åse Marie Hansen, Jane Frolund Thomsen, Anette Kaergaard, Reiner Ernst Rugulies, Sigurd Mikkelsen, Johan Hviid Andersen, Ole Mors, Matias Grynderup, Jens Peter Bonde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

ABSTRACT: BACKGROUND: Low participation in population-based follow-up studies addressing psychosocial risk factors may cause biased estimation of health risk but the issue has seldom been examined. We compared risk estimates for selected health outcomes among respondents and the entire source population. METHODS: In a Danish cohort study of associations between psychosocial characteristics of the work environment and mental health, the source population of public service workers comprised 10,036 employees in 502 work units of which 4,489 participated (participation rate 45%). Data on the psychosocial work environment were obtained for each work unit by calculating the average of the employee self-reports. The average values were assigned all employees and non-respondent at the work unit. Outcome data on sick leave and prescription of antidepressant medication during the follow-up period (1.4.2007-31.12.2008) was obtained by linkage to national registries. RESULTS: Respondents differed at baseline from non-respondents by gender, age, employment status, sick leave and hospitalization for affective disorders. However, risk estimates for sick leave and prescription of antidepressant medication, during follow-up, based on the subset of participants, did only differ marginally from risk estimates based upon the entire population. CONCLUSIONS: We found no indications that low participation at baseline distorts the estimates of associations between the work unit level of psychosocial work environment and mental health outcomes during follow-up. These results may not be valid for other exposures or outcomes.
OriginalsprogEngelsk
TidsskriftB M C Public Health
Vol/bind11
Udgave nummer1
Sider (fra-til)539
ISSN1471-2458
DOI
StatusUdgivet - 8. jul. 2011

Fingeraftryk

Sick Leave
Population
Prescriptions
Mental Health
Health
Self Report
Registries
Cohort Studies
Surveys and Questionnaires

Citer dette

Kaerlev, L., Kolstad, H., Hansen, Å. M., Frolund Thomsen, J., Kaergaard, A., Rugulies, R. E., ... Bonde, J. P. (2011). Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation? B M C Public Health, 11(1), 539. https://doi.org/10.1186/1471-2458-11-539
Kaerlev, Linda ; Kolstad, Henrik ; Hansen, Åse Marie ; Frolund Thomsen, Jane ; Kaergaard, Anette ; Rugulies, Reiner Ernst ; Mikkelsen, Sigurd ; Andersen, Johan Hviid ; Mors, Ole ; Grynderup, Matias ; Bonde, Jens Peter. / Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation?. I: B M C Public Health. 2011 ; Bind 11, Nr. 1. s. 539.
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title = "Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation?",
abstract = "ABSTRACT: BACKGROUND: Low participation in population-based follow-up studies addressing psychosocial risk factors may cause biased estimation of health risk but the issue has seldom been examined. We compared risk estimates for selected health outcomes among respondents and the entire source population. METHODS: In a Danish cohort study of associations between psychosocial characteristics of the work environment and mental health, the source population of public service workers comprised 10,036 employees in 502 work units of which 4,489 participated (participation rate 45{\%}). Data on the psychosocial work environment were obtained for each work unit by calculating the average of the employee self-reports. The average values were assigned all employees and non-respondent at the work unit. Outcome data on sick leave and prescription of antidepressant medication during the follow-up period (1.4.2007-31.12.2008) was obtained by linkage to national registries. RESULTS: Respondents differed at baseline from non-respondents by gender, age, employment status, sick leave and hospitalization for affective disorders. However, risk estimates for sick leave and prescription of antidepressant medication, during follow-up, based on the subset of participants, did only differ marginally from risk estimates based upon the entire population. CONCLUSIONS: We found no indications that low participation at baseline distorts the estimates of associations between the work unit level of psychosocial work environment and mental health outcomes during follow-up. These results may not be valid for other exposures or outcomes.",
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Kaerlev, L, Kolstad, H, Hansen, ÅM, Frolund Thomsen, J, Kaergaard, A, Rugulies, RE, Mikkelsen, S, Andersen, JH, Mors, O, Grynderup, M & Bonde, JP 2011, 'Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation?', B M C Public Health, bind 11, nr. 1, s. 539. https://doi.org/10.1186/1471-2458-11-539

Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation? / Kaerlev, Linda; Kolstad, Henrik; Hansen, Åse Marie; Frolund Thomsen, Jane; Kaergaard, Anette; Rugulies, Reiner Ernst; Mikkelsen, Sigurd; Andersen, Johan Hviid; Mors, Ole; Grynderup, Matias; Bonde, Jens Peter.

I: B M C Public Health, Bind 11, Nr. 1, 08.07.2011, s. 539.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation?

AU - Kaerlev, Linda

AU - Kolstad, Henrik

AU - Hansen, Åse Marie

AU - Frolund Thomsen, Jane

AU - Kaergaard, Anette

AU - Rugulies, Reiner Ernst

AU - Mikkelsen, Sigurd

AU - Andersen, Johan Hviid

AU - Mors, Ole

AU - Grynderup, Matias

AU - Bonde, Jens Peter

PY - 2011/7/8

Y1 - 2011/7/8

N2 - ABSTRACT: BACKGROUND: Low participation in population-based follow-up studies addressing psychosocial risk factors may cause biased estimation of health risk but the issue has seldom been examined. We compared risk estimates for selected health outcomes among respondents and the entire source population. METHODS: In a Danish cohort study of associations between psychosocial characteristics of the work environment and mental health, the source population of public service workers comprised 10,036 employees in 502 work units of which 4,489 participated (participation rate 45%). Data on the psychosocial work environment were obtained for each work unit by calculating the average of the employee self-reports. The average values were assigned all employees and non-respondent at the work unit. Outcome data on sick leave and prescription of antidepressant medication during the follow-up period (1.4.2007-31.12.2008) was obtained by linkage to national registries. RESULTS: Respondents differed at baseline from non-respondents by gender, age, employment status, sick leave and hospitalization for affective disorders. However, risk estimates for sick leave and prescription of antidepressant medication, during follow-up, based on the subset of participants, did only differ marginally from risk estimates based upon the entire population. CONCLUSIONS: We found no indications that low participation at baseline distorts the estimates of associations between the work unit level of psychosocial work environment and mental health outcomes during follow-up. These results may not be valid for other exposures or outcomes.

AB - ABSTRACT: BACKGROUND: Low participation in population-based follow-up studies addressing psychosocial risk factors may cause biased estimation of health risk but the issue has seldom been examined. We compared risk estimates for selected health outcomes among respondents and the entire source population. METHODS: In a Danish cohort study of associations between psychosocial characteristics of the work environment and mental health, the source population of public service workers comprised 10,036 employees in 502 work units of which 4,489 participated (participation rate 45%). Data on the psychosocial work environment were obtained for each work unit by calculating the average of the employee self-reports. The average values were assigned all employees and non-respondent at the work unit. Outcome data on sick leave and prescription of antidepressant medication during the follow-up period (1.4.2007-31.12.2008) was obtained by linkage to national registries. RESULTS: Respondents differed at baseline from non-respondents by gender, age, employment status, sick leave and hospitalization for affective disorders. However, risk estimates for sick leave and prescription of antidepressant medication, during follow-up, based on the subset of participants, did only differ marginally from risk estimates based upon the entire population. CONCLUSIONS: We found no indications that low participation at baseline distorts the estimates of associations between the work unit level of psychosocial work environment and mental health outcomes during follow-up. These results may not be valid for other exposures or outcomes.

U2 - 10.1186/1471-2458-11-539

DO - 10.1186/1471-2458-11-539

M3 - Journal article

VL - 11

SP - 539

JO - B M C Public Health

JF - B M C Public Health

SN - 1471-2458

IS - 1

ER -