Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes?

Lars Ulrik Gerdes, C Gerdes, P S Hansen, I C Klausen, O Faergeman

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    The epsilon 3 allele in the human gene coding for apolipoprotein E (apoE) is the most common worldwide, but epsilon 4 is probably the ancestral allele. Since apoE is involved in many important biological processes, selection forces could have favoured epsilon 3. We hypothesized that apoE genotypes may affect reproductive efficiency, and we therefore compared the distributions of 40-year-old married men with known genotypes by the numbers of their biological children. The distributions were statistically significantly different (P = 0.0026). On average, men with the epsilon 3 epsilon 3 genotype (n = 212) had 1.93 children, men with the epsilon 3 epsilon 4 or epsilon 4 epsilon 4 genotype (n = 105) had 1.50, and men with the epsilon 3 epsilon 2 or epsilon 2 epsilon 2 genotypes (n = 53) had 1.66 children. Of the men in the three groups, 6%, 26% and 19%, respectively, reported being childless. These findings are unlikely to be due to gross error in the reported prevalence of childlessness, differences in socioeconomic status or other likely sources of bias. They are compatible with higher fertility in men with the epsilon 3 epsilon 3 genotype than in those with the other common apoE genotypes.

    OriginalsprogEngelsk
    TidsskriftHuman Genetics
    Vol/bind98
    Udgave nummer2
    Sider (fra-til)239-42
    Antal sider4
    ISSN0340-6717
    StatusUdgivet - aug. 1996

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    Gerdes, Lars Ulrik ; Gerdes, C ; Hansen, P S ; Klausen, I C ; Faergeman, O. / Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes?. I: Human Genetics. 1996 ; Bind 98, Nr. 2. s. 239-42.
    @article{84e11db27c284c10b5ce50c7916aac2f,
    title = "Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes?",
    abstract = "The epsilon 3 allele in the human gene coding for apolipoprotein E (apoE) is the most common worldwide, but epsilon 4 is probably the ancestral allele. Since apoE is involved in many important biological processes, selection forces could have favoured epsilon 3. We hypothesized that apoE genotypes may affect reproductive efficiency, and we therefore compared the distributions of 40-year-old married men with known genotypes by the numbers of their biological children. The distributions were statistically significantly different (P = 0.0026). On average, men with the epsilon 3 epsilon 3 genotype (n = 212) had 1.93 children, men with the epsilon 3 epsilon 4 or epsilon 4 epsilon 4 genotype (n = 105) had 1.50, and men with the epsilon 3 epsilon 2 or epsilon 2 epsilon 2 genotypes (n = 53) had 1.66 children. Of the men in the three groups, 6{\%}, 26{\%} and 19{\%}, respectively, reported being childless. These findings are unlikely to be due to gross error in the reported prevalence of childlessness, differences in socioeconomic status or other likely sources of bias. They are compatible with higher fertility in men with the epsilon 3 epsilon 3 genotype than in those with the other common apoE genotypes.",
    keywords = "Adult, Alleles, Apolipoprotein E2, Apolipoprotein E3, Apolipoprotein E4, Apolipoproteins E, Child, Denmark, Evolution, Molecular, Fertility, Genotype, Humans, Male",
    author = "Gerdes, {Lars Ulrik} and C Gerdes and Hansen, {P S} and Klausen, {I C} and O Faergeman",
    year = "1996",
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    journal = "Human Genetics",
    issn = "0340-6717",
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    }

    Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes? / Gerdes, Lars Ulrik; Gerdes, C; Hansen, P S; Klausen, I C; Faergeman, O.

    I: Human Genetics, Bind 98, Nr. 2, 08.1996, s. 239-42.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Are men carrying the apolipoprotein epsilon 4- or epsilon 2 allele less fertile than epsilon 3 epsilon 3 genotypes?

    AU - Gerdes, Lars Ulrik

    AU - Gerdes, C

    AU - Hansen, P S

    AU - Klausen, I C

    AU - Faergeman, O

    PY - 1996/8

    Y1 - 1996/8

    N2 - The epsilon 3 allele in the human gene coding for apolipoprotein E (apoE) is the most common worldwide, but epsilon 4 is probably the ancestral allele. Since apoE is involved in many important biological processes, selection forces could have favoured epsilon 3. We hypothesized that apoE genotypes may affect reproductive efficiency, and we therefore compared the distributions of 40-year-old married men with known genotypes by the numbers of their biological children. The distributions were statistically significantly different (P = 0.0026). On average, men with the epsilon 3 epsilon 3 genotype (n = 212) had 1.93 children, men with the epsilon 3 epsilon 4 or epsilon 4 epsilon 4 genotype (n = 105) had 1.50, and men with the epsilon 3 epsilon 2 or epsilon 2 epsilon 2 genotypes (n = 53) had 1.66 children. Of the men in the three groups, 6%, 26% and 19%, respectively, reported being childless. These findings are unlikely to be due to gross error in the reported prevalence of childlessness, differences in socioeconomic status or other likely sources of bias. They are compatible with higher fertility in men with the epsilon 3 epsilon 3 genotype than in those with the other common apoE genotypes.

    AB - The epsilon 3 allele in the human gene coding for apolipoprotein E (apoE) is the most common worldwide, but epsilon 4 is probably the ancestral allele. Since apoE is involved in many important biological processes, selection forces could have favoured epsilon 3. We hypothesized that apoE genotypes may affect reproductive efficiency, and we therefore compared the distributions of 40-year-old married men with known genotypes by the numbers of their biological children. The distributions were statistically significantly different (P = 0.0026). On average, men with the epsilon 3 epsilon 3 genotype (n = 212) had 1.93 children, men with the epsilon 3 epsilon 4 or epsilon 4 epsilon 4 genotype (n = 105) had 1.50, and men with the epsilon 3 epsilon 2 or epsilon 2 epsilon 2 genotypes (n = 53) had 1.66 children. Of the men in the three groups, 6%, 26% and 19%, respectively, reported being childless. These findings are unlikely to be due to gross error in the reported prevalence of childlessness, differences in socioeconomic status or other likely sources of bias. They are compatible with higher fertility in men with the epsilon 3 epsilon 3 genotype than in those with the other common apoE genotypes.

    KW - Adult

    KW - Alleles

    KW - Apolipoprotein E2

    KW - Apolipoprotein E3

    KW - Apolipoprotein E4

    KW - Apolipoproteins E

    KW - Child

    KW - Denmark

    KW - Evolution, Molecular

    KW - Fertility

    KW - Genotype

    KW - Humans

    KW - Male

    M3 - Journal article

    C2 - 8698352

    VL - 98

    SP - 239

    EP - 242

    JO - Human Genetics

    JF - Human Genetics

    SN - 0340-6717

    IS - 2

    ER -