Are hypertensive women at additional risk of ischaemic heart disease from physically demanding work?

Karen Allesøe, Karen Søgaard, Mette Aadahl, Eleanor Boyle, Andreas Holtermann

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: The combination of hypertension and high physical activity at work may increase blood pressure considerably and increase the risk of atherosclerosis and thereby ischaemic heart disease (IHD), but only a few studies in men, and none among women, have examined this topic.

DESIGN: This was a prospective cohort study.

METHODS: In 1993, 12,093 female nurses from the Danish Nurse Cohort Study, aged 45-64 years answered a baseline questionnaire on physical activity at work, history of hypertension, a selection of known risk factors for IHD and occupational factors. Information on incident IHD from baseline to 2008 was retrieved by individual linkage to the National Register of Hospital Discharges.

RESULTS: In a fully adjusted Cox model, hypertensive nurses with high physical activity at work had nearly three times higher risk of IHD (hazard ratio (HR) 2.87 (95% confidence interval (CI) 2.12-3.87)) compared to normotensive nurses with moderate physical activity at work. Significant additive interaction between physical activity at work and hypertension was found measured by the relative excess risk due to additive interaction (RERI) (1.20 (95% CI 0.26-2.14), and in an additive hazards model. Hypertensive nurses with high physical activity at work had 60 additional cases of IHD per 10,000 person years compared to normotensive nurses with moderate physical activity at work (60.0 (95% CI 38.1-81.9; p < 0.001)), of which more than half was explained by additive interaction (40.7 (95% CI 11.7-69.7; p = 0.006)). No multiplicative interaction (p = 0.249) was found.

CONCLUSIONS: This study among Danish nurses indicated that hypertensive women may be at particular high risk of IHD from physically demanding work.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Preventive Cardiology
Vol/bind23
Udgave nummer10
Sider (fra-til)1054-1061
ISSN2047-4873
DOI
StatusUdgivet - jul. 2016

Fingeraftryk

Nurses
Exercise
Confidence Intervals
Proportional Hazards Models
Cohort Studies
Prospective Studies

Citer dette

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title = "Are hypertensive women at additional risk of ischaemic heart disease from physically demanding work?",
abstract = "BACKGROUND: The combination of hypertension and high physical activity at work may increase blood pressure considerably and increase the risk of atherosclerosis and thereby ischaemic heart disease (IHD), but only a few studies in men, and none among women, have examined this topic.DESIGN: This was a prospective cohort study.METHODS: In 1993, 12,093 female nurses from the Danish Nurse Cohort Study, aged 45-64 years answered a baseline questionnaire on physical activity at work, history of hypertension, a selection of known risk factors for IHD and occupational factors. Information on incident IHD from baseline to 2008 was retrieved by individual linkage to the National Register of Hospital Discharges.RESULTS: In a fully adjusted Cox model, hypertensive nurses with high physical activity at work had nearly three times higher risk of IHD (hazard ratio (HR) 2.87 (95{\%} confidence interval (CI) 2.12-3.87)) compared to normotensive nurses with moderate physical activity at work. Significant additive interaction between physical activity at work and hypertension was found measured by the relative excess risk due to additive interaction (RERI) (1.20 (95{\%} CI 0.26-2.14), and in an additive hazards model. Hypertensive nurses with high physical activity at work had 60 additional cases of IHD per 10,000 person years compared to normotensive nurses with moderate physical activity at work (60.0 (95{\%} CI 38.1-81.9; p < 0.001)), of which more than half was explained by additive interaction (40.7 (95{\%} CI 11.7-69.7; p = 0.006)). No multiplicative interaction (p = 0.249) was found.CONCLUSIONS: This study among Danish nurses indicated that hypertensive women may be at particular high risk of IHD from physically demanding work.",
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Are hypertensive women at additional risk of ischaemic heart disease from physically demanding work? / Allesøe, Karen ; Søgaard, Karen; Aadahl, Mette; Boyle, Eleanor; Holtermann, Andreas.

I: European Journal of Preventive Cardiology, Bind 23 , Nr. 10, 07.2016, s. 1054-1061.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Are hypertensive women at additional risk of ischaemic heart disease from physically demanding work?

AU - Allesøe, Karen

AU - Søgaard, Karen

AU - Aadahl, Mette

AU - Boyle, Eleanor

AU - Holtermann, Andreas

N1 - © The European Society of Cardiology 2016.

PY - 2016/7

Y1 - 2016/7

N2 - BACKGROUND: The combination of hypertension and high physical activity at work may increase blood pressure considerably and increase the risk of atherosclerosis and thereby ischaemic heart disease (IHD), but only a few studies in men, and none among women, have examined this topic.DESIGN: This was a prospective cohort study.METHODS: In 1993, 12,093 female nurses from the Danish Nurse Cohort Study, aged 45-64 years answered a baseline questionnaire on physical activity at work, history of hypertension, a selection of known risk factors for IHD and occupational factors. Information on incident IHD from baseline to 2008 was retrieved by individual linkage to the National Register of Hospital Discharges.RESULTS: In a fully adjusted Cox model, hypertensive nurses with high physical activity at work had nearly three times higher risk of IHD (hazard ratio (HR) 2.87 (95% confidence interval (CI) 2.12-3.87)) compared to normotensive nurses with moderate physical activity at work. Significant additive interaction between physical activity at work and hypertension was found measured by the relative excess risk due to additive interaction (RERI) (1.20 (95% CI 0.26-2.14), and in an additive hazards model. Hypertensive nurses with high physical activity at work had 60 additional cases of IHD per 10,000 person years compared to normotensive nurses with moderate physical activity at work (60.0 (95% CI 38.1-81.9; p < 0.001)), of which more than half was explained by additive interaction (40.7 (95% CI 11.7-69.7; p = 0.006)). No multiplicative interaction (p = 0.249) was found.CONCLUSIONS: This study among Danish nurses indicated that hypertensive women may be at particular high risk of IHD from physically demanding work.

AB - BACKGROUND: The combination of hypertension and high physical activity at work may increase blood pressure considerably and increase the risk of atherosclerosis and thereby ischaemic heart disease (IHD), but only a few studies in men, and none among women, have examined this topic.DESIGN: This was a prospective cohort study.METHODS: In 1993, 12,093 female nurses from the Danish Nurse Cohort Study, aged 45-64 years answered a baseline questionnaire on physical activity at work, history of hypertension, a selection of known risk factors for IHD and occupational factors. Information on incident IHD from baseline to 2008 was retrieved by individual linkage to the National Register of Hospital Discharges.RESULTS: In a fully adjusted Cox model, hypertensive nurses with high physical activity at work had nearly three times higher risk of IHD (hazard ratio (HR) 2.87 (95% confidence interval (CI) 2.12-3.87)) compared to normotensive nurses with moderate physical activity at work. Significant additive interaction between physical activity at work and hypertension was found measured by the relative excess risk due to additive interaction (RERI) (1.20 (95% CI 0.26-2.14), and in an additive hazards model. Hypertensive nurses with high physical activity at work had 60 additional cases of IHD per 10,000 person years compared to normotensive nurses with moderate physical activity at work (60.0 (95% CI 38.1-81.9; p < 0.001)), of which more than half was explained by additive interaction (40.7 (95% CI 11.7-69.7; p = 0.006)). No multiplicative interaction (p = 0.249) was found.CONCLUSIONS: This study among Danish nurses indicated that hypertensive women may be at particular high risk of IHD from physically demanding work.

U2 - 10.1177/2047487316631681

DO - 10.1177/2047487316631681

M3 - Journal article

C2 - 26876489

VL - 23

SP - 1054

EP - 1061

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 10

ER -