Antistoffer hos patienter med kronisk inflammatorisk demyeliniserende polyneuropati

Abdullahi Ahmed Momamed, Thomas Krøigård, Thomas Agerbo Gaist, Lars Kjøbsted Markvardsen, Søren Hein Sindrup, Henning Andersen, Morten Blaabjerg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Recent studies have identified specific immunoglobulin (Ig) G4 antibodies against the paranodal proteins neurofascin 155 and contactin 1 in subgroups of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). These patients present with distinct clinical phenotypes and poor response to first-line therapy with intravenous Ig. Detection of these antibodies in patients with CIDP has diagnostic, prognostic, and therapeutic implications. This review summarises the current knowledge on clinical characteristics, pathogenesis and treatment of these patients.
OriginalsprogDansk
ArtikelnummerV08180526
TidsskriftUgeskrift for Laeger
Vol/bind181
Udgave nummer16
ISSN0041-5782
StatusUdgivet - aug. 2019

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