Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCAs in Denmark (2001-2010). The risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of the event. Overall, treatment with any antipsychotic drug was associated with OHCA (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.23-1.89), as was use with typical antipsychotics (OR = 1.66, CI: 1.27-2.17). By contrast, overall, atypical antipsychotic drug use was not (OR = 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs, haloperidol (OR = 2.43, CI: 1.20-4.93) and levomepromazine (OR = 2.05, CI: 1.18-3.56), were associated with OHCA, as was one atypical antipsychotic drug, quetiapine (OR = 3.64, CI: 1.59-8.30).
ISI Document Delivery No.: AQ3FN Times Cited: 0 Cited Reference Count: 46 Weeke, P. Jensen, A. Folke, F. Gislason, G. H. Olesen, J. B. Fosbol, E. L. Wissenberg, M. Lippert, F. K. Christensen, E. F. Nielsen, S. L. Holm, E. Kanters, J. K. Poulsen, H. E. Kober, L. Torp-Pedersen, C. Tryg Foundation, TrygFonden, Denmark [7343-09]; Novo Nordisk Foundation P.W. was funded by an unrestricted research grant from the Tryg Foundation (J.nr. 7343-09, TrygFonden, Denmark). G.H.G. is supported by an independent research scholarship from the Novo Nordisk Foundation. 0 NATURE PUBLISHING GROUP NEW YORK CLIN PHARMACOL THER