Antiobesity mechanisms of action of conjugated linoleic acid

Arion Kennedy, Kristina Martinez, Soren Schmidt, Susanne Mandrup, Kathleen LaPoint, Michael McIntosh

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.
OriginalsprogEngelsk
TidsskriftThe Journal of Nutritional Biochemistry
Vol/bind21
Udgave nummer3
Sider (fra-til)171-9
Antal sider9
DOI
StatusUdgivet - 1. mar. 2010

Fingeraftryk

Conjugated Linoleic Acids
Adiposity
Dietary Supplements
Dietary supplements
Beef
Adipogenesis
Dairies
Lipid Metabolism
Isomers
Energy Metabolism
Animals
Fatty Acids
Apoptosis

Citer dette

Kennedy, Arion ; Martinez, Kristina ; Schmidt, Soren ; Mandrup, Susanne ; LaPoint, Kathleen ; McIntosh, Michael. / Antiobesity mechanisms of action of conjugated linoleic acid. I: The Journal of Nutritional Biochemistry. 2010 ; Bind 21, Nr. 3. s. 171-9.
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abstract = "Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.",
keywords = "Adipogenesis, Adiposity, Animals, Apoptosis, Body Weight, Dietary Fats, Unsaturated, Dietary Supplements, Energy Metabolism, Humans, Inflammation, Linoleic Acids, Conjugated, Lipid Metabolism, Obesity, Species Specificity",
author = "Arion Kennedy and Kristina Martinez and Soren Schmidt and Susanne Mandrup and Kathleen LaPoint and Michael McIntosh",
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Antiobesity mechanisms of action of conjugated linoleic acid. / Kennedy, Arion; Martinez, Kristina; Schmidt, Soren; Mandrup, Susanne; LaPoint, Kathleen; McIntosh, Michael.

I: The Journal of Nutritional Biochemistry, Bind 21, Nr. 3, 01.03.2010, s. 171-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Antiobesity mechanisms of action of conjugated linoleic acid

AU - Kennedy, Arion

AU - Martinez, Kristina

AU - Schmidt, Soren

AU - Mandrup, Susanne

AU - LaPoint, Kathleen

AU - McIntosh, Michael

N1 - 2010 Elsevier Inc. All rights reserved.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.

AB - Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.

KW - Adipogenesis

KW - Adiposity

KW - Animals

KW - Apoptosis

KW - Body Weight

KW - Dietary Fats, Unsaturated

KW - Dietary Supplements

KW - Energy Metabolism

KW - Humans

KW - Inflammation

KW - Linoleic Acids, Conjugated

KW - Lipid Metabolism

KW - Obesity

KW - Species Specificity

U2 - 10.1016/j.jnutbio.2009.08.003

DO - 10.1016/j.jnutbio.2009.08.003

M3 - Journal article

C2 - 19954947

VL - 21

SP - 171

EP - 179

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

IS - 3

ER -