Antiobesity mechanisms of action of conjugated linoleic acid

Arion Kennedy, Kristina Martinez, Soren Schmidt, Susanne Mandrup, Kathleen LaPoint, Michael McIntosh

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.
OriginalsprogEngelsk
TidsskriftThe Journal of Nutritional Biochemistry
Vol/bind21
Udgave nummer3
Sider (fra-til)171-9
Antal sider9
DOI
StatusUdgivet - 1. mar. 2010

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