TY - JOUR
T1 - Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA)
T2 - A Systematic Review of the Clinical Evidence
AU - Bergqvist, David
AU - Lindeman, Johannes H N
AU - Lindholt, Jes Sanddal
AU - Björck, Martin
PY - 2013
Y1 - 2013
N2 - Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.
AB - Antimicrobial treatment to attenuate expansion of abdominal aortic aneurysm has been suggested, especially with the focus on Chlamydophila. In this systematic literature review only four randomized trials were identified. In two small studies there is an indication of an effect of roxithromycin. In conclusion, however, more studies are needed, and they must be properly sized based on power calculations as well as antimicrobially relevant. Such trials are on the way both in Europe and the US, the results being awaited with interest.
KW - Antibiotic
KW - Aortic aneurysm
KW - Expansion
KW - Macrolide
KW - Tetracycline
KW - Humans
KW - Randomized Controlled Trials as Topic
KW - Chlamydophila Infections/complications
KW - Chlamydophila/isolation & purification
KW - Animals
KW - Roxithromycin/therapeutic use
KW - Anti-Bacterial Agents/therapeutic use
KW - Aortic Aneurysm, Abdominal/drug therapy
U2 - 10.2174/1570161111311030002
DO - 10.2174/1570161111311030002
M3 - Journal article
C2 - 22724481
SN - 1570-1611
VL - 11
SP - 288
EP - 292
JO - Current Vascular Pharmacology
JF - Current Vascular Pharmacology
IS - 3
ER -