Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators

Joan Forns, Anton Pottegård, Tammo Reinders, Beatriz Poblador-Plou, Rosa Morros, Lena Brandt, Miguel Cainzos-Achirica, Maja Hellfritzsch, Tania Schink, Alexandra Prados-Torres, Maria Giner-Soriano, David Hägg, Jesper Hallas, Jordi Cortés, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez-Gutthann, Manel Pladevall, Johan Reutfors

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Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results: Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations: The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions: Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.

OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind249
Sider (fra-til)242-252
ISSN0165-0327
DOI
StatusUdgivet - 2019

Fingeraftryk

Denmark
Germany
Comorbidity
Incidence
S 20098
Citalopram
Paroxetine
Fluoxetine
Amitriptyline
Information Storage and Retrieval
Sertraline
Prescriptions

Emneord

    Citer dette

    Forns, Joan ; Pottegård, Anton ; Reinders, Tammo ; Poblador-Plou, Beatriz ; Morros, Rosa ; Brandt, Lena ; Cainzos-Achirica, Miguel ; Hellfritzsch, Maja ; Schink, Tania ; Prados-Torres, Alexandra ; Giner-Soriano, Maria ; Hägg, David ; Hallas, Jesper ; Cortés, Jordi ; Jacquot, Emmanuelle ; Deltour, Nicolas ; Perez-Gutthann, Susana ; Pladevall, Manel ; Reutfors, Johan. / Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators. I: Journal of Affective Disorders. 2019 ; Bind 249. s. 242-252.
    @article{73fc9eb409344549adefc90b48611f18,
    title = "Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators",
    abstract = "Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results: Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations: The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions: Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.",
    keywords = "Antidepressants, Comorbidity, Drug utilization study, Europe",
    author = "Joan Forns and Anton Potteg{\aa}rd and Tammo Reinders and Beatriz Poblador-Plou and Rosa Morros and Lena Brandt and Miguel Cainzos-Achirica and Maja Hellfritzsch and Tania Schink and Alexandra Prados-Torres and Maria Giner-Soriano and David H{\"a}gg and Jesper Hallas and Jordi Cort{\'e}s and Emmanuelle Jacquot and Nicolas Deltour and Susana Perez-Gutthann and Manel Pladevall and Johan Reutfors",
    year = "2019",
    doi = "10.1016/j.jad.2019.02.010",
    language = "English",
    volume = "249",
    pages = "242--252",
    journal = "Journal of Affective Disorders",
    issn = "0165-0327",
    publisher = "Elsevier",

    }

    Forns, J, Pottegård, A, Reinders, T, Poblador-Plou, B, Morros, R, Brandt, L, Cainzos-Achirica, M, Hellfritzsch, M, Schink, T, Prados-Torres, A, Giner-Soriano, M, Hägg, D, Hallas, J, Cortés, J, Jacquot, E, Deltour, N, Perez-Gutthann, S, Pladevall, M & Reutfors, J 2019, 'Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators' Journal of Affective Disorders, bind 249, s. 242-252. https://doi.org/10.1016/j.jad.2019.02.010

    Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators. / Forns, Joan; Pottegård, Anton; Reinders, Tammo; Poblador-Plou, Beatriz; Morros, Rosa; Brandt, Lena; Cainzos-Achirica, Miguel; Hellfritzsch, Maja; Schink, Tania; Prados-Torres, Alexandra; Giner-Soriano, Maria; Hägg, David; Hallas, Jesper; Cortés, Jordi; Jacquot, Emmanuelle; Deltour, Nicolas; Perez-Gutthann, Susana; Pladevall, Manel; Reutfors, Johan.

    I: Journal of Affective Disorders, Bind 249, 2019, s. 242-252.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014

    T2 - Incidence and comorbidities of antidepressant initiators

    AU - Forns, Joan

    AU - Pottegård, Anton

    AU - Reinders, Tammo

    AU - Poblador-Plou, Beatriz

    AU - Morros, Rosa

    AU - Brandt, Lena

    AU - Cainzos-Achirica, Miguel

    AU - Hellfritzsch, Maja

    AU - Schink, Tania

    AU - Prados-Torres, Alexandra

    AU - Giner-Soriano, Maria

    AU - Hägg, David

    AU - Hallas, Jesper

    AU - Cortés, Jordi

    AU - Jacquot, Emmanuelle

    AU - Deltour, Nicolas

    AU - Perez-Gutthann, Susana

    AU - Pladevall, Manel

    AU - Reutfors, Johan

    PY - 2019

    Y1 - 2019

    N2 - Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results: Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations: The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions: Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.

    AB - Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results: Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations: The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions: Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.

    KW - Antidepressants

    KW - Comorbidity

    KW - Drug utilization study

    KW - Europe

    U2 - 10.1016/j.jad.2019.02.010

    DO - 10.1016/j.jad.2019.02.010

    M3 - Journal article

    VL - 249

    SP - 242

    EP - 252

    JO - Journal of Affective Disorders

    JF - Journal of Affective Disorders

    SN - 0165-0327

    ER -