Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates

Katrine Kielsen, Zaiba Shamim, Lars P Ryder, Flemming Nielsen, Philippe Grandjean, Esben Budtz-Jørgensen, Carsten Heilmann

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.

OriginalsprogEngelsk
TidsskriftJournal of Immunotoxicology
Vol/bind13
Udgave nummer2
Sider (fra-til)270-273
ISSN1547-691X
DOI
StatusUdgivet - 16. jul. 2015

Fingeraftryk

Diphtheria
Antibodies
Serum
Animals
Antigens

Citer dette

Kielsen, Katrine ; Shamim, Zaiba ; Ryder, Lars P ; Nielsen, Flemming ; Grandjean, Philippe ; Budtz-Jørgensen, Esben ; Heilmann, Carsten. / Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates. I: Journal of Immunotoxicology. 2015 ; Bind 13, Nr. 2. s. 270-273.
@article{5d6b893a8bd8498ea4de689f26247a1b,
title = "Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates",
abstract = "Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.",
author = "Katrine Kielsen and Zaiba Shamim and Ryder, {Lars P} and Flemming Nielsen and Philippe Grandjean and Esben Budtz-J{\o}rgensen and Carsten Heilmann",
year = "2015",
month = "7",
day = "16",
doi = "10.3109/1547691X.2015.1067259",
language = "English",
volume = "13",
pages = "270--273",
journal = "Journal of Immunotoxicology",
issn = "1547-691X",
publisher = "Taylor & Francis",
number = "2",

}

Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates. / Kielsen, Katrine; Shamim, Zaiba; Ryder, Lars P; Nielsen, Flemming; Grandjean, Philippe; Budtz-Jørgensen, Esben; Heilmann, Carsten.

I: Journal of Immunotoxicology, Bind 13, Nr. 2, 16.07.2015, s. 270-273.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates

AU - Kielsen, Katrine

AU - Shamim, Zaiba

AU - Ryder, Lars P

AU - Nielsen, Flemming

AU - Grandjean, Philippe

AU - Budtz-Jørgensen, Esben

AU - Heilmann, Carsten

PY - 2015/7/16

Y1 - 2015/7/16

N2 - Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.

AB - Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.

U2 - 10.3109/1547691X.2015.1067259

DO - 10.3109/1547691X.2015.1067259

M3 - Journal article

C2 - 26181512

VL - 13

SP - 270

EP - 273

JO - Journal of Immunotoxicology

JF - Journal of Immunotoxicology

SN - 1547-691X

IS - 2

ER -