Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland; Nicole H. Trier; Cecilie Kyllesbech; Anette H. Draborg; Rimantas Slibinskas; Evaldas Ciplys; Jette L. Frederiksen; Gunnar Houen

doi:10.1016/j.imlet.2023.02.003

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Helena Gåsland
, Nicole H. Trier
, Cecilie Kyllesbech
, Anette H. Draborg
, Rimantas Slibinskas
, Evaldas Ciplys
, Jette L. Frederiksen
, Gunnar Houen^*

^*Kontaktforfatter

Institut for Biokemi og Molekylær Biologi

Rigshospitalet
Syddansk Universitet
Statens Serum Institut
Vilnius University

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

Originalsprog	Engelsk
Tidsskrift	Immunology Letters
Vol/bind	254
Sider (fra-til)	54-64
ISSN	0165-2478
DOI	https://doi.org/10.1016/j.imlet.2023.02.003
Status	Udgivet - feb. 2023

Bibliografisk note

Funding Information:
We would like to thank L.F. Foghts Fond, Stibo Fonden and Oda & Hans Svenningsens Fond for their generous funding to the research project.

Publisher Copyright:
© 2023

Finansiering

We would like to thank L.F. Foghts Fond, Stibo Fonden and Oda & Hans Svenningsens Fond for their generous funding to the research project.

Dokumenter og links

10.1016/j.imlet.2023.02.003

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@article{a44f3a1102c84c6191ab99b603337bff,

title = "Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis",

abstract = "An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.",

keywords = "Antibodies, Antibody correlations, Antibody index, Multiple sclerosis, Optic neuritis, Virus antigens",

author = "Helena G{\aa}sland and Trier, \{Nicole H.\} and Cecilie Kyllesbech and Draborg, \{Anette H.\} and Rimantas Slibinskas and Evaldas Ciplys and Frederiksen, \{Jette L.\} and Gunnar Houen",

note = "Funding Information: We would like to thank L.F. Foghts Fond, Stibo Fonden and Oda \& Hans Svenningsens Fond for their generous funding to the research project. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = feb,

doi = "10.1016/j.imlet.2023.02.003",

language = "English",

volume = "254",

pages = "54--64",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

}

TY - JOUR

T1 - Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

AU - Gåsland, Helena

AU - Trier, Nicole H.

AU - Kyllesbech, Cecilie

AU - Draborg, Anette H.

AU - Slibinskas, Rimantas

AU - Ciplys, Evaldas

AU - Frederiksen, Jette L.

AU - Houen, Gunnar

PY - 2023/2

Y1 - 2023/2

N2 - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

AB - An antigen panel consisting of Epstein-Barr, measles, mumps, varicella zoster and rubella viruses (EMMRZ) was recently presented, which may aid in the diagnosis of multiple sclerosis (MS). The aim of this study was to validate and extend the EMMRZ panel. Various candidates, such as Cytomegalovirus and John Cunningham virus were analysed in relapsing-remitting MS (RRMS) and optic neuritis (ON) samples by enzyme-linked immunosorbent assay. IgG levels were elevated in RRMS samples and correlations were found between serum and cerebrospinal fluid levels. Cohort-dependent optimized panels were obtained for RRMS and ON, which obtained the highest sensitivity when combined with the status of oligoclonal bands.

KW - Antibodies

KW - Antibody correlations

KW - Antibody index

KW - Multiple sclerosis

KW - Optic neuritis

KW - Virus antigens

UR - https://doi.org/10.1016/j.imlet.2025.107067

U2 - 10.1016/j.imlet.2023.02.003

DO - 10.1016/j.imlet.2023.02.003

M3 - Journal article

C2 - 36764611

AN - SCOPUS:85147858594

SN - 0165-2478

VL - 254

SP - 54

EP - 64

JO - Immunology Letters

JF - Immunology Letters

ER -

Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis

Abstract

Bibliografisk note

Finansiering

Dokumenter og links

SDU link

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Citationsformater