Anti-HIV-1 and cytotoxicity of a new dimeric thiazepine alkaloid isolated from Ixora undulata Roxb. leaves

Magdy M.D. Mohammed*, Khaled M. Mohamed

*Kontaktforfatter for dette arbejde

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Abstrakt

The crude alkaloidal extract of Ixora undulata Roxb. leaves recorded a cytotoxicity of IC50 = 125 µg/mL against EL4 and revealed a reduction with CC50 = 47 µg/mL in the viability of MT-4 cells, beside a 50% protection with EC50 > 47 µg/mL against HIV-1IIIB. Bioassay guided fractionation of the crude alkaloidal extract of I. undulata leaves led to the isolation of a new dimeric thiazepine alkaloid, together with the monomer and its glycoside. The isolated alkaloids were structurally elucidated based on extensive nuclear magnetic resonance spectroscopy, infrared, and HRESI/MS. The isolated alkaloids were evaluated for their anti-HIV-1 and cytotoxic activities, while the obtained results revealed promising activity with structure-based relationship, which is discussed briefly.

OriginalsprogEngelsk
TidsskriftMedicinal Chemistry Research
Vol/bind26
Udgave nummer9
Sider (fra-til)2119–2126
ISSN1054-2523
DOI
StatusUdgivet - 2017

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