Anomalies of tooth formation in hypohidrotic ectodermal dysplasia

Michala Oron Lexner, Allan Bardow, Jens Michael Hertz, Lis Nielsen, Sven Kreiborg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The X-linked hypohidrotic ectodermal dysplasia (HED) is the most common type of ectodermal dysplasia. The clinical identification of possible heterozygous females can be difficult because of the varying degrees of clinical signs caused by X-chromosome inactivation. This study is the first to elaborate on anomalies of tooth formation found in a group of hemizygous males and heterozygous females with known ED1 mutations. These tooth anomalies may be used as dental biomarkers for heterozygous females, enabling an earlier diagnosis, and therefore, better treatment and genetic counselling.
OriginalsprogEngelsk
TidsskriftInternational Journal of Paediatric Dentistry (Print)
Vol/bind17
Udgave nummer1
Sider (fra-til)10-8
Antal sider9
ISSN0960-7439
DOI
StatusUdgivet - 2007

Fingeraftryk

Anhidrotic Ectodermal Dysplasia 1
X Chromosome Inactivation
Genetic Counseling
Mutation

Citer dette

Lexner, Michala Oron ; Bardow, Allan ; Hertz, Jens Michael ; Nielsen, Lis ; Kreiborg, Sven. / Anomalies of tooth formation in hypohidrotic ectodermal dysplasia. I: International Journal of Paediatric Dentistry (Print). 2007 ; Bind 17, Nr. 1. s. 10-8.
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abstract = "The X-linked hypohidrotic ectodermal dysplasia (HED) is the most common type of ectodermal dysplasia. The clinical identification of possible heterozygous females can be difficult because of the varying degrees of clinical signs caused by X-chromosome inactivation. This study is the first to elaborate on anomalies of tooth formation found in a group of hemizygous males and heterozygous females with known ED1 mutations. These tooth anomalies may be used as dental biomarkers for heterozygous females, enabling an earlier diagnosis, and therefore, better treatment and genetic counselling.",
keywords = "Adolescent, Adult, Aged, Anodontia, Biological Markers, Case-Control Studies, Child, Child, Preschool, Dental Models, Ectodermal Dysplasia 1, Anhidrotic, Female, Heterozygote, Humans, Incisor, Male, Middle Aged, Molar, Mutation, Odontometry, Photography, Dental, Radiography, Panoramic, Tooth Abnormalities, Tooth Crown, Tooth Root",
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Anomalies of tooth formation in hypohidrotic ectodermal dysplasia. / Lexner, Michala Oron; Bardow, Allan; Hertz, Jens Michael; Nielsen, Lis; Kreiborg, Sven.

I: International Journal of Paediatric Dentistry (Print), Bind 17, Nr. 1, 2007, s. 10-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Anomalies of tooth formation in hypohidrotic ectodermal dysplasia

AU - Lexner, Michala Oron

AU - Bardow, Allan

AU - Hertz, Jens Michael

AU - Nielsen, Lis

AU - Kreiborg, Sven

PY - 2007

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AB - The X-linked hypohidrotic ectodermal dysplasia (HED) is the most common type of ectodermal dysplasia. The clinical identification of possible heterozygous females can be difficult because of the varying degrees of clinical signs caused by X-chromosome inactivation. This study is the first to elaborate on anomalies of tooth formation found in a group of hemizygous males and heterozygous females with known ED1 mutations. These tooth anomalies may be used as dental biomarkers for heterozygous females, enabling an earlier diagnosis, and therefore, better treatment and genetic counselling.

KW - Adolescent

KW - Adult

KW - Aged

KW - Anodontia

KW - Biological Markers

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KW - Dental Models

KW - Ectodermal Dysplasia 1, Anhidrotic

KW - Female

KW - Heterozygote

KW - Humans

KW - Incisor

KW - Male

KW - Middle Aged

KW - Molar

KW - Mutation

KW - Odontometry

KW - Photography, Dental

KW - Radiography, Panoramic

KW - Tooth Abnormalities

KW - Tooth Crown

KW - Tooth Root

U2 - 10.1111/j.1365-263X.2006.00801.x

DO - 10.1111/j.1365-263X.2006.00801.x

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JO - International Journal of Paediatric Dentistry (Print)

JF - International Journal of Paediatric Dentistry (Print)

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