Anogenital distance as a phenotypic signature through infancy

Lærke Priskorn, Jørgen H Petersen, Niels Jørgensen, Henriette B Kyhl, Marianne S Andersen, Katharina M Main, Anna-Maria Andersson, Niels E Skakkebaek, Tina K Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements.

METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months and some children were furthermore examined by two different examiners. We assessed age related changes and reproducibility of measurements.

RESULTS: AGD increased between the two examinations and correlated within the child. A large proportion of the observed variation in AGD was due to true differences between the children (AGDas: 62%, AGDap: 40%, AGDaf: 30%, AGDac: 21%), and measurement error due to between- and within-examiner variation was low.

CONCLUSIONS: Our study showed that measures of AGD within a child correlated during infancy, especially in boys and particularly for AGD measured as the distance between anus and scrotum. A planned cohort follow-up through childhood and puberty will reveal whether AGD represents a phenotypic signature throughout life.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.287.

OriginalsprogEngelsk
TidsskriftPediatric Research
Vol/bind83
Udgave nummer3
Sider (fra-til)573–579
ISSN0031-3998
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Clitoris
Scrotum
Penis
Equidae
Pediatrics
Research

Citer dette

Priskorn, Lærke ; Petersen, Jørgen H ; Jørgensen, Niels ; Kyhl, Henriette B ; Andersen, Marianne S ; Main, Katharina M ; Andersson, Anna-Maria ; Skakkebaek, Niels E ; Jensen, Tina K. / Anogenital distance as a phenotypic signature through infancy. I: Pediatric Research. 2018 ; Bind 83, Nr. 3. s. 573–579.
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abstract = "BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements.METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months and some children were furthermore examined by two different examiners. We assessed age related changes and reproducibility of measurements.RESULTS: AGD increased between the two examinations and correlated within the child. A large proportion of the observed variation in AGD was due to true differences between the children (AGDas: 62{\%}, AGDap: 40{\%}, AGDaf: 30{\%}, AGDac: 21{\%}), and measurement error due to between- and within-examiner variation was low.CONCLUSIONS: Our study showed that measures of AGD within a child correlated during infancy, especially in boys and particularly for AGD measured as the distance between anus and scrotum. A planned cohort follow-up through childhood and puberty will reveal whether AGD represents a phenotypic signature throughout life.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.287.",
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Priskorn, L, Petersen, JH, Jørgensen, N, Kyhl, HB, Andersen, MS, Main, KM, Andersson, A-M, Skakkebaek, NE & Jensen, TK 2018, 'Anogenital distance as a phenotypic signature through infancy', Pediatric Research, bind 83, nr. 3, s. 573–579. https://doi.org/10.1038/pr.2017.287

Anogenital distance as a phenotypic signature through infancy. / Priskorn, Lærke; Petersen, Jørgen H; Jørgensen, Niels; Kyhl, Henriette B; Andersen, Marianne S; Main, Katharina M; Andersson, Anna-Maria; Skakkebaek, Niels E; Jensen, Tina K.

I: Pediatric Research, Bind 83, Nr. 3, 03.2018, s. 573–579.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Anogenital distance as a phenotypic signature through infancy

AU - Priskorn, Lærke

AU - Petersen, Jørgen H

AU - Jørgensen, Niels

AU - Kyhl, Henriette B

AU - Andersen, Marianne S

AU - Main, Katharina M

AU - Andersson, Anna-Maria

AU - Skakkebaek, Niels E

AU - Jensen, Tina K

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements.METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months and some children were furthermore examined by two different examiners. We assessed age related changes and reproducibility of measurements.RESULTS: AGD increased between the two examinations and correlated within the child. A large proportion of the observed variation in AGD was due to true differences between the children (AGDas: 62%, AGDap: 40%, AGDaf: 30%, AGDac: 21%), and measurement error due to between- and within-examiner variation was low.CONCLUSIONS: Our study showed that measures of AGD within a child correlated during infancy, especially in boys and particularly for AGD measured as the distance between anus and scrotum. A planned cohort follow-up through childhood and puberty will reveal whether AGD represents a phenotypic signature throughout life.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.287.

AB - BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements.METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months and some children were furthermore examined by two different examiners. We assessed age related changes and reproducibility of measurements.RESULTS: AGD increased between the two examinations and correlated within the child. A large proportion of the observed variation in AGD was due to true differences between the children (AGDas: 62%, AGDap: 40%, AGDaf: 30%, AGDac: 21%), and measurement error due to between- and within-examiner variation was low.CONCLUSIONS: Our study showed that measures of AGD within a child correlated during infancy, especially in boys and particularly for AGD measured as the distance between anus and scrotum. A planned cohort follow-up through childhood and puberty will reveal whether AGD represents a phenotypic signature throughout life.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.287.

KW - Journal Article

U2 - 10.1038/pr.2017.287

DO - 10.1038/pr.2017.287

M3 - Journal article

C2 - 29155806

VL - 83

SP - 573

EP - 579

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 3

ER -