Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Volker Gerke*, Felicity N.E. Gavins, Michael Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted, Ursula Rescher*

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Abstract

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

OriginalsprogEngelsk
Artikelnummer1574
TidsskriftNature Communications
Vol/bind15
Udgave nummer1
Antal sider15
ISSN2041-1723
DOI
StatusUdgivet - dec. 2024

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