Angiotensin type 2 receptor (AT2R) and receptor Mas

a complex liaison

Daniel Villela, Julia Leonhardt, Neal Patel, Jason Joseph, Sebastian Kirsch, Anders Hallberg, Thomas Unger, Michael Bader, Robson A Santos, Colin Sumners, Ulrike Muscha Steckelings

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists for one receptor are able to inhibit the action of agonists for the respective other receptor. These observations suggest that there may be a functional or even physical interaction of both receptors. This article discusses potential mechanisms underlying the phenomenon of blockade of angiotensin-(1-7) [Ang-(1-7)] actions by AT2R antagonists and vice versa. Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects. We conclude that evidence for a functional interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning.

OriginalsprogEngelsk
TidsskriftClinical Science
Vol/bind128
Udgave nummer4
Sider (fra-til)227-234
ISSN0143-5221
DOI
StatusUdgivet - feb. 2015

Fingeraftryk

Angiotensin Type 2 Receptor
Dimerization
Angiotensin II Type 2 Receptor Blockers
Renin-Angiotensin System
Ligands
angiotensin I (1-7)
Action Spectrum

Citer dette

Villela, D., Leonhardt, J., Patel, N., Joseph, J., Kirsch, S., Hallberg, A., ... Steckelings, U. M. (2015). Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison. Clinical Science, 128(4), 227-234. https://doi.org/10.1042/CS20130515
Villela, Daniel ; Leonhardt, Julia ; Patel, Neal ; Joseph, Jason ; Kirsch, Sebastian ; Hallberg, Anders ; Unger, Thomas ; Bader, Michael ; Santos, Robson A ; Sumners, Colin ; Steckelings, Ulrike Muscha. / Angiotensin type 2 receptor (AT2R) and receptor Mas : a complex liaison. I: Clinical Science. 2015 ; Bind 128, Nr. 4. s. 227-234.
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abstract = "The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists for one receptor are able to inhibit the action of agonists for the respective other receptor. These observations suggest that there may be a functional or even physical interaction of both receptors. This article discusses potential mechanisms underlying the phenomenon of blockade of angiotensin-(1-7) [Ang-(1-7)] actions by AT2R antagonists and vice versa. Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects. We conclude that evidence for a functional interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning.",
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Villela, D, Leonhardt, J, Patel, N, Joseph, J, Kirsch, S, Hallberg, A, Unger, T, Bader, M, Santos, RA, Sumners, C & Steckelings, UM 2015, 'Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison', Clinical Science, bind 128, nr. 4, s. 227-234. https://doi.org/10.1042/CS20130515

Angiotensin type 2 receptor (AT2R) and receptor Mas : a complex liaison. / Villela, Daniel; Leonhardt, Julia; Patel, Neal; Joseph, Jason; Kirsch, Sebastian; Hallberg, Anders; Unger, Thomas; Bader, Michael; Santos, Robson A; Sumners, Colin; Steckelings, Ulrike Muscha.

I: Clinical Science, Bind 128, Nr. 4, 02.2015, s. 227-234.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Angiotensin type 2 receptor (AT2R) and receptor Mas

T2 - a complex liaison

AU - Villela, Daniel

AU - Leonhardt, Julia

AU - Patel, Neal

AU - Joseph, Jason

AU - Kirsch, Sebastian

AU - Hallberg, Anders

AU - Unger, Thomas

AU - Bader, Michael

AU - Santos, Robson A

AU - Sumners, Colin

AU - Steckelings, Ulrike Muscha

PY - 2015/2

Y1 - 2015/2

N2 - The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists for one receptor are able to inhibit the action of agonists for the respective other receptor. These observations suggest that there may be a functional or even physical interaction of both receptors. This article discusses potential mechanisms underlying the phenomenon of blockade of angiotensin-(1-7) [Ang-(1-7)] actions by AT2R antagonists and vice versa. Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects. We conclude that evidence for a functional interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning.

AB - The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists for one receptor are able to inhibit the action of agonists for the respective other receptor. These observations suggest that there may be a functional or even physical interaction of both receptors. This article discusses potential mechanisms underlying the phenomenon of blockade of angiotensin-(1-7) [Ang-(1-7)] actions by AT2R antagonists and vice versa. Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects. We conclude that evidence for a functional interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning.

U2 - 10.1042/CS20130515

DO - 10.1042/CS20130515

M3 - Journal article

VL - 128

SP - 227

EP - 234

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 4

ER -

Villela D, Leonhardt J, Patel N, Joseph J, Kirsch S, Hallberg A et al. Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison. Clinical Science. 2015 feb;128(4):227-234. https://doi.org/10.1042/CS20130515