Angiotensin II receptors and neuroprotection

Robert E. Widdop, Ulrike Muscha Steckelings, Claudia A. McCarthy, Jennifer K. Callaway

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Resumé

It is well recognized that stroke and related cerebral ischemia is one of the most common causes of mortality in the developed world, not to mention the immense burden of morbidity and disability that afflicts stroke survivors. It is also well recognized that blood pressure (BP) control is critical in reducing the incidence of stroke (MacMahon et al. 1990). On this point, drugs that inhibit the rennin-angiotensin system (RAS) are increasingly used in preventative strategies against stroke or recurrent stroke (HOPE 2000; PROGRESS 2001; Dahlof et al. 2002). However, as will be discussed, data from animal studies investigating stroke also suggest that part of the neuroprotective effect of AT1 receptor antagonists is independent of BP. This fact also points to direct central interference of the brain RAS, which was originally described over 3 decades ago (Unger et al. 1988; Steckelings, Bottari, and Unger 1992).

OriginalsprogEngelsk
TitelNeuropeptides in Neuroprotection and Neuroregeneration
Antal sider14
ForlagCRC Press/Balkema
Publikationsdato1. jan. 2012
Sider165-178
ISBN (Trykt)9781439830628
ISBN (Elektronisk)9781439830635
DOI
StatusUdgivet - 1. jan. 2012

Fingeraftryk

Angiotensin Receptors
Chymosin
Neuroprotective Agents
Survivors
Neuroprotection
Incidence
Pharmaceutical Preparations

Citer dette

Widdop, R. E., Steckelings, U. M., McCarthy, C. A., & Callaway, J. K. (2012). Angiotensin II receptors and neuroprotection. I Neuropeptides in Neuroprotection and Neuroregeneration (s. 165-178). CRC Press/Balkema. https://doi.org/10.1201/b12279
Widdop, Robert E. ; Steckelings, Ulrike Muscha ; McCarthy, Claudia A. ; Callaway, Jennifer K. / Angiotensin II receptors and neuroprotection. Neuropeptides in Neuroprotection and Neuroregeneration. CRC Press/Balkema, 2012. s. 165-178
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Widdop, RE, Steckelings, UM, McCarthy, CA & Callaway, JK 2012, Angiotensin II receptors and neuroprotection. i Neuropeptides in Neuroprotection and Neuroregeneration. CRC Press/Balkema, s. 165-178. https://doi.org/10.1201/b12279

Angiotensin II receptors and neuroprotection. / Widdop, Robert E.; Steckelings, Ulrike Muscha; McCarthy, Claudia A.; Callaway, Jennifer K.

Neuropeptides in Neuroprotection and Neuroregeneration. CRC Press/Balkema, 2012. s. 165-178.

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

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Widdop RE, Steckelings UM, McCarthy CA, Callaway JK. Angiotensin II receptors and neuroprotection. I Neuropeptides in Neuroprotection and Neuroregeneration. CRC Press/Balkema. 2012. s. 165-178 https://doi.org/10.1201/b12279