Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications

S P Bottari, M de Gasparo, Ulrike Muscha Steckelings, N R Levens

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Thanks to the recent discovery of angiotensin II (ANG II) receptor subtypes linked to different signalling pathways, research in the different areas related to this peptide has regained a strong interest. In the following review, we first describe the biochemistry and actions of angiotensin peptides formed both in the circulation and locally at the tissue and organ level. Evidence for the existence and distribution of ANG II receptor subtypes in mammalian as well as in nonmammalian species and lower organisms is presented. The changes in receptor subtype expression during development and disease are described. The signal transduction mechanisms and biological actions of ANG II mediated by the recently cloned AT1 receptor are reviewed and the recent data concerning the signalling pathways linked to the AT2 receptor are discussed. Finally, based upon their molecular pharmacology, we present evidence and also speculate upon the physiological function of the ANG II receptor subtypes.
OriginalsprogEngelsk
TidsskriftFrontiers in Neuroendocrinology
Vol/bind14
Udgave nummer2
Sider (fra-til)123-71
Antal sider49
ISSN0091-3022
DOI
StatusUdgivet - 1993
Udgivet eksterntJa

Fingeraftryk

Angiotensin Receptors
Peptides
Research

Citer dette

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Angiotensin II receptor subtypes : characterization, signalling mechanisms, and possible physiological implications. / Bottari, S P; de Gasparo, M; Steckelings, Ulrike Muscha; Levens, N R.

I: Frontiers in Neuroendocrinology, Bind 14, Nr. 2, 1993, s. 123-71.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Angiotensin II receptor subtypes

T2 - characterization, signalling mechanisms, and possible physiological implications

AU - Bottari, S P

AU - de Gasparo, M

AU - Steckelings, Ulrike Muscha

AU - Levens, N R

PY - 1993

Y1 - 1993

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DO - 10.1006/frne.1993.1005

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JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

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