Studies of younger individuals have suggested an association between ACE genotype and physical and cognitive performance. Using a longitudinal study of elderly twins we studied the association between ACE genotype and physical and cognitive functioning and survival in old age.
Frederiksen, H., Gaist, D., Bathum, L., Andersen, K., McGue, M., Vaupel, J. W., & Christensen, K. (2003). Angiotensin I - Converting Enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival: A follow-up study of elderly Danish Twins. Annals of Epidemiology, 13(1), 57-65. https://doi.org/10.1016/S1047-2797(02)00254-5