Angiographic coronary stenosis versus (15)O-water PET myocardial blood flow

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Resumé

Purpose: To examine which of stress myocardial flow (MBF) and
coronary flow reserve (CFR) determined by (15)-water-PET (PET)
correspond most closely with diameter stenosis assessed by quantitative
coronary angiography (QCA).
Methods: Twenty-three patients with a C40% QCA stenosis underwent
baseline and adenosine stress PET. Baseline MBF measures were
corrected for myocardial workload and stress MBF and CFR calculated
in 17 standard AHA myocardial segments and reassigned to respective
feeding vessels. If multiple stenoses, only the most severe stenosis was
considered. Pearson’s correlation coefficients were calculated and
compared using Fisher r-to-z transformation.
Results: A total of 35 QCA stenoses were identified with a mean
diameter stenosis of 75% ± 18%, range 45-100%. Stress MBF and
CFR in corresponding vascular territories were: 1.84 ± 0.78 and
1.86 ± 1.05 mL/minute/g, respectively. MBF was significantly correlated
to QCA stenosis severity: r = -0.46, P = .006, whereas CFR
was not, r = -0.28, P = .097. These two r values did not differ significantly,
P = .42. In contrast, stress MBF and CFR were significantly
correlated (C): r = 0.86, P\.001.
Conclusions: The correlation between anatomic and functional stenosis
was poor, suggesting that the hemodynamic consequences of
angiographically proven coronary stenoses should be examined by
functional imaging like PET.
OriginalsprogEngelsk
TidsskriftJournal of Nuclear Cardiology
Vol/bindVolume 20
Udgave nummerSupplement, May/June 2013
Sider (fra-til)33
Antal sider1
ISSN1071-3581
StatusUdgivet - 1. maj 2013

Citer dette

@article{4ae3863992a4443cac378bd69091d1ee,
title = "Angiographic coronary stenosis versus (15)O-water PET myocardial blood flow",
abstract = "Purpose: To examine which of stress myocardial flow (MBF) and coronary flow reserve (CFR) determined by (15)-water-PET (PET) correspond most closely with diameter stenosis assessed by quantitative coronary angiography (QCA). Methods: Twenty-three patients with a C40{\%} QCA stenosis underwent baseline and adenosine stress PET. Baseline MBF measures were corrected for myocardial workload and stress MBF and CFR calculated in 17 standard AHA myocardial segments and reassigned to respective feeding vessels. If multiple stenoses, only the most severe stenosis was considered. Pearson’s correlation coefficients were calculated and compared using Fisher r-to-z transformation. Results: A total of 35 QCA stenoses were identified with a mean diameter stenosis of 75{\%} ± 18{\%}, range 45-100{\%}. Stress MBF and CFR in corresponding vascular territories were: 1.84 ± 0.78 and 1.86 ± 1.05 mL/minute/g, respectively. MBF was significantly correlated to QCA stenosis severity: r = -0.46, P = .006, whereas CFR was not, r = -0.28, P = .097. These two r values did not differ significantly, P = .42. In contrast, stress MBF and CFR were significantly correlated (C): r = 0.86, P\.001. Conclusions: The correlation between anatomic and functional stenosis was poor, suggesting that the hemodynamic consequences of angiographically proven coronary stenoses should be examined by functional imaging like PET.",
author = "Anders Thomassen and Poul-Erik Braad and Allan Johansen and Henrik Petersen and Diederichsen, {Axel Cosmus Pyndt} and Hans Mickley and Jensen, {Lisette Okkels} and Per Thayssen and Bj{\"o}rn Blomberg and H{\o}ilund-Carlsen, {Poul Flemming}",
year = "2013",
month = "5",
day = "1",
language = "English",
volume = "Volume 20",
pages = "33",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",
number = "Supplement, May/June 2013",

}

Angiographic coronary stenosis versus (15)O-water PET myocardial blood flow. / Thomassen, Anders; Braad, Poul-Erik; Johansen, Allan; Petersen, Henrik ; Diederichsen, Axel Cosmus Pyndt; Mickley, Hans; Jensen, Lisette Okkels; Thayssen, Per; Blomberg, Björn; Høilund-Carlsen, Poul Flemming.

I: Journal of Nuclear Cardiology, Bind Volume 20, Nr. Supplement, May/June 2013, 01.05.2013, s. 33.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - Angiographic coronary stenosis versus (15)O-water PET myocardial blood flow

AU - Thomassen, Anders

AU - Braad, Poul-Erik

AU - Johansen, Allan

AU - Petersen, Henrik

AU - Diederichsen, Axel Cosmus Pyndt

AU - Mickley, Hans

AU - Jensen, Lisette Okkels

AU - Thayssen, Per

AU - Blomberg, Björn

AU - Høilund-Carlsen, Poul Flemming

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Purpose: To examine which of stress myocardial flow (MBF) and coronary flow reserve (CFR) determined by (15)-water-PET (PET) correspond most closely with diameter stenosis assessed by quantitative coronary angiography (QCA). Methods: Twenty-three patients with a C40% QCA stenosis underwent baseline and adenosine stress PET. Baseline MBF measures were corrected for myocardial workload and stress MBF and CFR calculated in 17 standard AHA myocardial segments and reassigned to respective feeding vessels. If multiple stenoses, only the most severe stenosis was considered. Pearson’s correlation coefficients were calculated and compared using Fisher r-to-z transformation. Results: A total of 35 QCA stenoses were identified with a mean diameter stenosis of 75% ± 18%, range 45-100%. Stress MBF and CFR in corresponding vascular territories were: 1.84 ± 0.78 and 1.86 ± 1.05 mL/minute/g, respectively. MBF was significantly correlated to QCA stenosis severity: r = -0.46, P = .006, whereas CFR was not, r = -0.28, P = .097. These two r values did not differ significantly, P = .42. In contrast, stress MBF and CFR were significantly correlated (C): r = 0.86, P\.001. Conclusions: The correlation between anatomic and functional stenosis was poor, suggesting that the hemodynamic consequences of angiographically proven coronary stenoses should be examined by functional imaging like PET.

AB - Purpose: To examine which of stress myocardial flow (MBF) and coronary flow reserve (CFR) determined by (15)-water-PET (PET) correspond most closely with diameter stenosis assessed by quantitative coronary angiography (QCA). Methods: Twenty-three patients with a C40% QCA stenosis underwent baseline and adenosine stress PET. Baseline MBF measures were corrected for myocardial workload and stress MBF and CFR calculated in 17 standard AHA myocardial segments and reassigned to respective feeding vessels. If multiple stenoses, only the most severe stenosis was considered. Pearson’s correlation coefficients were calculated and compared using Fisher r-to-z transformation. Results: A total of 35 QCA stenoses were identified with a mean diameter stenosis of 75% ± 18%, range 45-100%. Stress MBF and CFR in corresponding vascular territories were: 1.84 ± 0.78 and 1.86 ± 1.05 mL/minute/g, respectively. MBF was significantly correlated to QCA stenosis severity: r = -0.46, P = .006, whereas CFR was not, r = -0.28, P = .097. These two r values did not differ significantly, P = .42. In contrast, stress MBF and CFR were significantly correlated (C): r = 0.86, P\.001. Conclusions: The correlation between anatomic and functional stenosis was poor, suggesting that the hemodynamic consequences of angiographically proven coronary stenoses should be examined by functional imaging like PET.

M3 - Conference abstract in journal

VL - Volume 20

SP - 33

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - Supplement, May/June 2013

ER -