Anesthesia Neurotoxicity in the Developing Brain

Basic Studies Relevant for Neonatal or Perinatal Medicine

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Diagnostic and invasive procedures in premature infants may require general anesthesia. General anesthetics interfere with the development of the immature animal brain. Accelerated apoptosis, disturbed synaptogenesis, and cytoarchitecture are among the mechanisms suspected to underlie this phenomenon. The implications for humans are unknown. This article presents current suspected mechanisms of anesthesia-induced neurotoxicity and elaborates on the difficulties in translating results from animal research to human. Ethical considerations limit the conduct of such experiments in human neonates, but the use of animal models is still considered feasible. Vulnerable periods in brain development need further identification as do neurotoxic and neuroprotective interventions.

OriginalsprogEngelsk
TidsskriftClinics in Perinatology
Vol/bind46
Udgave nummer4
Sider (fra-til)647-656
ISSN0095-5108
DOI
StatusUdgivet - 1. dec. 2019

Fingeraftryk

Medicine
Premature Infants
Newborn Infant
Apoptosis

Citer dette

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abstract = "Diagnostic and invasive procedures in premature infants may require general anesthesia. General anesthetics interfere with the development of the immature animal brain. Accelerated apoptosis, disturbed synaptogenesis, and cytoarchitecture are among the mechanisms suspected to underlie this phenomenon. The implications for humans are unknown. This article presents current suspected mechanisms of anesthesia-induced neurotoxicity and elaborates on the difficulties in translating results from animal research to human. Ethical considerations limit the conduct of such experiments in human neonates, but the use of animal models is still considered feasible. Vulnerable periods in brain development need further identification as do neurotoxic and neuroprotective interventions.",
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Anesthesia Neurotoxicity in the Developing Brain : Basic Studies Relevant for Neonatal or Perinatal Medicine. / Clausen, Nicola Groes; Hansen, Tom Giedsing; Disma, Nicola.

I: Clinics in Perinatology, Bind 46, Nr. 4, 01.12.2019, s. 647-656.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

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AU - Clausen, Nicola Groes

AU - Hansen, Tom Giedsing

AU - Disma, Nicola

PY - 2019/12/1

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KW - General anesthesia

KW - Neonatal anesthesia

KW - Neurocognitive outcome

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