Analysis of mass spectrometry data in proteomics

Rune Matthiesen, Ole N Jensen

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Abstrakt

The systematic study of proteins and protein networks, that is, proteomics, calls for qualitative and quantitative analysis of proteins and peptides. Mass spectrometry (MS) is a key analytical technology in current proteomics and modern mass spectrometers generate large amounts of high-quality data that in turn allow protein identification, annotation of secondary modifications, and determination of the absolute or relative abundance of individual proteins. Advances in mass spectrometry-driven proteomics rely on robust bioinformatics tools that enable large-scale data analysis. This chapter describes some of the basic concepts and current approaches to the analysis of MS and MS/MS data in proteomics.
OriginalsprogEngelsk
TidsskriftMethods in Molecular Biology
Vol/bind453
Udgave nummer1
Sider (fra-til)105-122
Antal sider17
ISSN1064-3745
DOI
StatusUdgivet - 2008

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