Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study

Moran Amit, Yoav Binenbaum, Kanika Sharma, Ramer Naomi D, Ramer Ilana, Agbetoba Abib, Brett Miles, Xinjie Yang, Delin Lei, Kristine Bjørndal, Christian Godballe, Mücke Thomas, Wolff Klaus-Dietrich, Dan Fliss, André M Eckardt, Copelli Chiara, Enrico Sesenna, Palmer Frank, Snehal Patel, Ziv Gil

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.
OriginalsprogEngelsk
TidsskriftHead & Neck (Print Edition)
Vol/bind36
Udgave nummer7
Sider (fra-til)998-1004
ISSN1043-3074
DOI
StatusUdgivet - 2014

Fingeraftryk

Adenoid Cystic Carcinoma
Disease-Free Survival
Neoplasms
Paranasal Sinuses
Multivariate Analysis

Citer dette

Amit, Moran ; Binenbaum, Yoav ; Sharma, Kanika ; Naomi D, Ramer ; Ilana, Ramer ; Abib, Agbetoba ; Miles, Brett ; Yang, Xinjie ; Lei, Delin ; Bjørndal, Kristine ; Godballe, Christian ; Thomas, Mücke ; Klaus-Dietrich, Wolff ; Fliss, Dan ; Eckardt, André M ; Chiara, Copelli ; Sesenna, Enrico ; Frank, Palmer ; Patel, Snehal ; Gil, Ziv. / Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study. I: Head & Neck (Print Edition). 2014 ; Bind 36, Nr. 7. s. 998-1004.
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title = "Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study",
abstract = "BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76{\%}, 80{\%} and 68{\%}, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.",
author = "Moran Amit and Yoav Binenbaum and Kanika Sharma and {Naomi D}, Ramer and Ramer Ilana and Agbetoba Abib and Brett Miles and Xinjie Yang and Delin Lei and Kristine Bj{\o}rndal and Christian Godballe and M{\"u}cke Thomas and Wolff Klaus-Dietrich and Dan Fliss and Eckardt, {Andr{\'e} M} and Copelli Chiara and Enrico Sesenna and Palmer Frank and Snehal Patel and Ziv Gil",
note = "Copyright {\circledC} 2013 Wiley Periodicals, Inc., A Wiley Company.",
year = "2014",
doi = "10.1002/hed.23405",
language = "English",
volume = "36",
pages = "998--1004",
journal = "Head & Neck (Print Edition)",
issn = "1043-3074",
publisher = "JohnWiley & Sons, Inc.",
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Amit, M, Binenbaum, Y, Sharma, K, Naomi D, R, Ilana, R, Abib, A, Miles, B, Yang, X, Lei, D, Bjørndal, K, Godballe, C, Thomas, M, Klaus-Dietrich, W, Fliss, D, Eckardt, AM, Chiara, C, Sesenna, E, Frank, P, Patel, S & Gil, Z 2014, 'Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study', Head & Neck (Print Edition), bind 36, nr. 7, s. 998-1004. https://doi.org/10.1002/hed.23405

Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study. / Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Naomi D, Ramer; Ilana, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Thomas, Mücke; Klaus-Dietrich, Wolff; Fliss, Dan; Eckardt, André M; Chiara, Copelli; Sesenna, Enrico; Frank, Palmer; Patel, Snehal; Gil, Ziv.

I: Head & Neck (Print Edition), Bind 36, Nr. 7, 2014, s. 998-1004.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study

AU - Amit, Moran

AU - Binenbaum, Yoav

AU - Sharma, Kanika

AU - Naomi D, Ramer

AU - Ilana, Ramer

AU - Abib, Agbetoba

AU - Miles, Brett

AU - Yang, Xinjie

AU - Lei, Delin

AU - Bjørndal, Kristine

AU - Godballe, Christian

AU - Thomas, Mücke

AU - Klaus-Dietrich, Wolff

AU - Fliss, Dan

AU - Eckardt, André M

AU - Chiara, Copelli

AU - Sesenna, Enrico

AU - Frank, Palmer

AU - Patel, Snehal

AU - Gil, Ziv

N1 - Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.

PY - 2014

Y1 - 2014

N2 - BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.

AB - BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.

U2 - 10.1002/hed.23405

DO - 10.1002/hed.23405

M3 - Journal article

VL - 36

SP - 998

EP - 1004

JO - Head & Neck (Print Edition)

JF - Head & Neck (Print Edition)

SN - 1043-3074

IS - 7

ER -