Abstrakt
The 5'-AMP-activated protein kinase AMPK functions as a master switch to maintain cellular and whole-body energy homeostasis and abnormal activity profiles of AMPK may cause pathological disorders. The present invention relates to a series of compounds (I) based on a pyrrolo[2,3-c]pyridine and a thieno[2,3- c]pyridine scaffold as AMPK inhibitors. In particular, the present invention relates to the synthesis of such compounds and the medical use of such compounds
| Originalsprog | Engelsk |
|---|---|
| IPC | A61K31/4365,A61K31/437,A61P25/00,A61P35/00,C07D471/04,C07D495/04 |
| Patentnummer | WO2019106087A1 |
| Journaliseringsdato | 29/11/2018 |
| Land/Område | Danmark |
| Prioritetsdato | 29/11/2017 |
| Prioritetsnummer | EP20170204381 |
| Status | Udgivet - 6. jun. 2019 |