Aktiviteter pr. år
Abstrakt
The synthesis of 2'-amino-LNA (locked nucleic acid) opens up exciting possibilities for modification of nucleic acids by conjugation to the 2'-nitrogen. Incorporation of unmodified and N-functionalized 2'-amino-LNA nucleotides improve duplex stability compared to unmodified DNA. 2'-Amino-LNA nucleosides derivatized with amino acids have been synthesized and incorporated into DNA oligonucleotides. Following oligonucleotide synthesis, peptides have been added using solid phase peptide coupling chem. Modification of oligonucleotides with pos. charged residues greatly improves thermal stability.
Originalsprog | Engelsk |
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Publikationsdato | 2010 |
Antal sider | 1 |
Status | Udgivet - 2010 |
Bibliografisk note
Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010Pages CARB-45
Relaterede Aktiviteter
- 1 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
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239th American Chemical Society National meeting
Marie Willaing Johannsen (Deltager)
21. mar. 2010 → 25. mar. 2010Aktivitet: Deltagelse i faglig begivenhed › Organisering af eller deltagelse i workshop, kursus, seminar eller lignende