Allergy and asthma prevention 2014

Antonio Nieto, Ulrich Wahn, Albrecht Bufe, Philippe Eigenmann, Susanne Halken, Gunilla Hedlin, Arne Høst, Jonathan Hourihane, Jocelyne Just, Gideon Lack, Susanne Lau, Paolo Maria Matricardi, Antonella Muraro, Nikos Papadopoulos, Graham Roberts, Angela Simpson, Erkka Valovirta, Stephan Weidinger, Magnus Wickman, Angel Mazon

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, pre-biotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.

OriginalsprogEngelsk
TidsskriftPediatric Allergy and Immunology
Vol/bind25
Udgave nummer6
Sider (fra-til)516-33
Antal sider18
ISSN0905-6157
DOI
StatusUdgivet - okt. 2014

Fingeraftryk

Hypersensitivity
Health Services Needs and Demand
Environmental Exposure
Probiotics
Atopic Dermatitis
Primary Prevention
Developed Countries
Epigenomics
Allergens
Medicine
Incidence

Citer dette

Nieto, A., Wahn, U., Bufe, A., Eigenmann, P., Halken, S., Hedlin, G., ... Mazon, A. (2014). Allergy and asthma prevention 2014. Pediatric Allergy and Immunology, 25(6), 516-33. https://doi.org/10.1111/pai.12272
Nieto, Antonio ; Wahn, Ulrich ; Bufe, Albrecht ; Eigenmann, Philippe ; Halken, Susanne ; Hedlin, Gunilla ; Høst, Arne ; Hourihane, Jonathan ; Just, Jocelyne ; Lack, Gideon ; Lau, Susanne ; Matricardi, Paolo Maria ; Muraro, Antonella ; Papadopoulos, Nikos ; Roberts, Graham ; Simpson, Angela ; Valovirta, Erkka ; Weidinger, Stephan ; Wickman, Magnus ; Mazon, Angel. / Allergy and asthma prevention 2014. I: Pediatric Allergy and Immunology. 2014 ; Bind 25, Nr. 6. s. 516-33.
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title = "Allergy and asthma prevention 2014",
abstract = "Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, pre-biotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.",
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Nieto, A, Wahn, U, Bufe, A, Eigenmann, P, Halken, S, Hedlin, G, Høst, A, Hourihane, J, Just, J, Lack, G, Lau, S, Matricardi, PM, Muraro, A, Papadopoulos, N, Roberts, G, Simpson, A, Valovirta, E, Weidinger, S, Wickman, M & Mazon, A 2014, 'Allergy and asthma prevention 2014', Pediatric Allergy and Immunology, bind 25, nr. 6, s. 516-33. https://doi.org/10.1111/pai.12272

Allergy and asthma prevention 2014. / Nieto, Antonio; Wahn, Ulrich; Bufe, Albrecht; Eigenmann, Philippe; Halken, Susanne; Hedlin, Gunilla; Høst, Arne; Hourihane, Jonathan; Just, Jocelyne; Lack, Gideon; Lau, Susanne; Matricardi, Paolo Maria; Muraro, Antonella; Papadopoulos, Nikos; Roberts, Graham; Simpson, Angela; Valovirta, Erkka; Weidinger, Stephan; Wickman, Magnus; Mazon, Angel.

I: Pediatric Allergy and Immunology, Bind 25, Nr. 6, 10.2014, s. 516-33.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Allergy and asthma prevention 2014

AU - Nieto, Antonio

AU - Wahn, Ulrich

AU - Bufe, Albrecht

AU - Eigenmann, Philippe

AU - Halken, Susanne

AU - Hedlin, Gunilla

AU - Høst, Arne

AU - Hourihane, Jonathan

AU - Just, Jocelyne

AU - Lack, Gideon

AU - Lau, Susanne

AU - Matricardi, Paolo Maria

AU - Muraro, Antonella

AU - Papadopoulos, Nikos

AU - Roberts, Graham

AU - Simpson, Angela

AU - Valovirta, Erkka

AU - Weidinger, Stephan

AU - Wickman, Magnus

AU - Mazon, Angel

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014/10

Y1 - 2014/10

N2 - Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, pre-biotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.

AB - Asthma and allergic diseases have become one of the epidemics of the 21st century in developed countries. Much of the success of other areas of medicine, such as infectious diseases, lies on preventive measures. Thus, much effort is also being placed lately in the prevention of asthma and allergy. This manuscript reviews the current evidence, divided into four areas of activity. Interventions modifying environmental exposure to allergens have provided inconsistent results, with multifaceted interventions being more effective in the prevention of asthma. Regarding nutrition, the use of hydrolyzed formulas in high-risk infants reduces the incidence of atopic dermatitis, while there is for now not enough evidence to recommend other dietary modifications, pre-biotics, probiotics, or other microbial products. Pharmacologic agents used until now for prevention have not proved useful, while there is hope that antiviral vaccines could be useful in the future. Allergen-specific immunotherapy is effective for the treatment of allergic patients with symptoms; the study of its value for primary and secondary prevention of asthma and allergy is in its very preliminary phases. The lack of success in the prevention of these disorders lies on their complexity, which involves many genetic, epigenetic, and environmental interactions. There is a need to identify target populations, involved mechanisms and interactions, and the best interventions. These must be effective, feasible, implementable, and affordable.

U2 - 10.1111/pai.12272

DO - 10.1111/pai.12272

M3 - Journal article

C2 - 25224992

VL - 25

SP - 516

EP - 533

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 6

ER -

Nieto A, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G et al. Allergy and asthma prevention 2014. Pediatric Allergy and Immunology. 2014 okt;25(6):516-33. https://doi.org/10.1111/pai.12272