Allergic sensitization among Danish infants at 13 months of age

BACKGROUND: Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.

METHODS: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals, with the aim of exploring nonspecific effects of neonatal Bacillus Calmette-Guérin vaccination. Participants at Kolding Hospital were invited to have a blood sample analyzed for allergic sensitization at 13 months of age. Telephone interviews gave information about allergic symptoms, and the children were examined for signs of atopic dermatitis at 3 and 13 months.

RESULTS: Of the 1241 children included in the Danish Calmette Study in Kolding 1066 (86%) had a blood sample drawn, representing 36% of the invited families. The blood sample cohort had a relatively high percentage of atopic predisposition (66.6%) and most mothers had a medium or long education. We found 90 infants (8.4%) to be sensitized, with sensitization against food items (milk, egg, peanut, and hazelnut) being the most common. Atopic dermatitis was found in 19% of the children, and it was significantly associated with sensitization against egg, peanut, wheat, cat, and dog.

CONCLUSION: In a partly selected Danish cohort, sensitization was present in 8% at 13 months of age, especially sensitization against food items. Children with atopic dermatitis were significantly more sensitized (16.6%). However, most sensitized children did not have any allergic symptoms at this age.