Allergic sensitization among Danish infants at 13 months of age

Lisbeth M Thøstesen*, Poul-Erik Kofoed

*Kontaktforfatter for dette arbejde

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Resumé

BACKGROUND: Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.

METHODS: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals, with the aim of exploring nonspecific effects of neonatal Bacillus Calmette-Guérin vaccination. Participants at Kolding Hospital were invited to have a blood sample analyzed for allergic sensitization at 13 months of age. Telephone interviews gave information about allergic symptoms, and the children were examined for signs of atopic dermatitis at 3 and 13 months.

RESULTS: Of the 1241 children included in the Danish Calmette Study in Kolding 1066 (86%) had a blood sample drawn, representing 36% of the invited families. The blood sample cohort had a relatively high percentage of atopic predisposition (66.6%) and most mothers had a medium or long education. We found 90 infants (8.4%) to be sensitized, with sensitization against food items (milk, egg, peanut, and hazelnut) being the most common. Atopic dermatitis was found in 19% of the children, and it was significantly associated with sensitization against egg, peanut, wheat, cat, and dog.

CONCLUSION: In a partly selected Danish cohort, sensitization was present in 8% at 13 months of age, especially sensitization against food items. Children with atopic dermatitis were significantly more sensitized (16.6%). However, most sensitized children did not have any allergic symptoms at this age.

OriginalsprogEngelsk
TidsskriftImmunity, Inflammation and Disease
Vol/bind7
Udgave nummer3
Sider (fra-til)183-190
ISSN2050-4527
DOI
StatusUdgivet - sep. 2019

Fingeraftryk

Atopic Dermatitis
Ovum
Corylus
Food
Triticum
Cats
Mothers
Dogs
Interviews
Education
Arachis
Dermatitis, Atopic, 3

Citer dette

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title = "Allergic sensitization among Danish infants at 13 months of age",
abstract = "BACKGROUND: Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.METHODS: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals, with the aim of exploring nonspecific effects of neonatal Bacillus Calmette-Gu{\'e}rin vaccination. Participants at Kolding Hospital were invited to have a blood sample analyzed for allergic sensitization at 13 months of age. Telephone interviews gave information about allergic symptoms, and the children were examined for signs of atopic dermatitis at 3 and 13 months.RESULTS: Of the 1241 children included in the Danish Calmette Study in Kolding 1066 (86{\%}) had a blood sample drawn, representing 36{\%} of the invited families. The blood sample cohort had a relatively high percentage of atopic predisposition (66.6{\%}) and most mothers had a medium or long education. We found 90 infants (8.4{\%}) to be sensitized, with sensitization against food items (milk, egg, peanut, and hazelnut) being the most common. Atopic dermatitis was found in 19{\%} of the children, and it was significantly associated with sensitization against egg, peanut, wheat, cat, and dog.CONCLUSION: In a partly selected Danish cohort, sensitization was present in 8{\%} at 13 months of age, especially sensitization against food items. Children with atopic dermatitis were significantly more sensitized (16.6{\%}). However, most sensitized children did not have any allergic symptoms at this age.",
keywords = "atopic dermatitis, infants, sensitization",
author = "Th{\o}stesen, {Lisbeth M} and Poul-Erik Kofoed",
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Allergic sensitization among Danish infants at 13 months of age. / Thøstesen, Lisbeth M; Kofoed, Poul-Erik.

I: Immunity, Inflammation and Disease, Bind 7, Nr. 3, 09.2019, s. 183-190.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Allergic sensitization among Danish infants at 13 months of age

AU - Thøstesen, Lisbeth M

AU - Kofoed, Poul-Erik

N1 - © 2019 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.METHODS: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals, with the aim of exploring nonspecific effects of neonatal Bacillus Calmette-Guérin vaccination. Participants at Kolding Hospital were invited to have a blood sample analyzed for allergic sensitization at 13 months of age. Telephone interviews gave information about allergic symptoms, and the children were examined for signs of atopic dermatitis at 3 and 13 months.RESULTS: Of the 1241 children included in the Danish Calmette Study in Kolding 1066 (86%) had a blood sample drawn, representing 36% of the invited families. The blood sample cohort had a relatively high percentage of atopic predisposition (66.6%) and most mothers had a medium or long education. We found 90 infants (8.4%) to be sensitized, with sensitization against food items (milk, egg, peanut, and hazelnut) being the most common. Atopic dermatitis was found in 19% of the children, and it was significantly associated with sensitization against egg, peanut, wheat, cat, and dog.CONCLUSION: In a partly selected Danish cohort, sensitization was present in 8% at 13 months of age, especially sensitization against food items. Children with atopic dermatitis were significantly more sensitized (16.6%). However, most sensitized children did not have any allergic symptoms at this age.

AB - BACKGROUND: Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. Sensitization is associated with, but not synonymous with, allergic disease.METHODS: The Danish Calmette Study was conducted from 2012 to 2015 at three Danish hospitals, with the aim of exploring nonspecific effects of neonatal Bacillus Calmette-Guérin vaccination. Participants at Kolding Hospital were invited to have a blood sample analyzed for allergic sensitization at 13 months of age. Telephone interviews gave information about allergic symptoms, and the children were examined for signs of atopic dermatitis at 3 and 13 months.RESULTS: Of the 1241 children included in the Danish Calmette Study in Kolding 1066 (86%) had a blood sample drawn, representing 36% of the invited families. The blood sample cohort had a relatively high percentage of atopic predisposition (66.6%) and most mothers had a medium or long education. We found 90 infants (8.4%) to be sensitized, with sensitization against food items (milk, egg, peanut, and hazelnut) being the most common. Atopic dermatitis was found in 19% of the children, and it was significantly associated with sensitization against egg, peanut, wheat, cat, and dog.CONCLUSION: In a partly selected Danish cohort, sensitization was present in 8% at 13 months of age, especially sensitization against food items. Children with atopic dermatitis were significantly more sensitized (16.6%). However, most sensitized children did not have any allergic symptoms at this age.

KW - atopic dermatitis

KW - infants

KW - sensitization

U2 - 10.1002/iid3.260

DO - 10.1002/iid3.260

M3 - Journal article

VL - 7

SP - 183

EP - 190

JO - Immunity, Inflammation and Disease

JF - Immunity, Inflammation and Disease

SN - 2050-4527

IS - 3

ER -