Allergic diseases among very preterm infants according to nutrition after hospital discharge

Gitte Zachariassen, Jan Faerk, Birgitte Esberg Boysen Kjær, Jesper Fenger-Gron, Sven Aage Mortensen, Henrik T Christesen, Susanne Halken

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

To determine whether a cow's milk-based human milk fortifier (HMF) added to mother's milk while breastfeeding or a cow's milk-based preterm formula compared to exclusively mother's milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life. Of a cohort of 324 VPI (gestational age 24-32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA. The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2% and 32.7%, while atopic dermatitis (AD) was 18.0% and 12.1%, respectively. Predisposition to allergic disease increased the risk of developing AD (p=0.04) [OR 2.6 (95% CI 1.0-6.4)] and the risk of developing RW (p=0.02) [OR 2.7 (95% CI 1.2-6.3)]. Boys had an increased risk of developing RW (p=0.003) [OR 3.1 (95% CI 1.5-6.5)]. No difference was found between nutrition groups. None developed food allergy. Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life.
OriginalsprogEngelsk
TidsskriftPediatric Allergy and Immunology
Vol/bind22
Udgave nummer5
Sider (fra-til)515-20
Antal sider6
ISSN0905-6157
DOI
StatusUdgivet - 2011

Fingeraftryk

Premature Infants
Human Milk
Atopic Dermatitis
Mothers
Food Hypersensitivity
Incidence
Allergens
Gestational Age

Citer dette

Zachariassen, Gitte ; Faerk, Jan ; Kjær, Birgitte Esberg Boysen ; Fenger-Gron, Jesper ; Mortensen, Sven Aage ; Christesen, Henrik T ; Halken, Susanne. / Allergic diseases among very preterm infants according to nutrition after hospital discharge. I: Pediatric Allergy and Immunology. 2011 ; Bind 22, Nr. 5. s. 515-20.
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abstract = "To determine whether a cow's milk-based human milk fortifier (HMF) added to mother's milk while breastfeeding or a cow's milk-based preterm formula compared to exclusively mother's milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life. Of a cohort of 324 VPI (gestational age 24-32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA. The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2{\%} and 32.7{\%}, while atopic dermatitis (AD) was 18.0{\%} and 12.1{\%}, respectively. Predisposition to allergic disease increased the risk of developing AD (p=0.04) [OR 2.6 (95{\%} CI 1.0-6.4)] and the risk of developing RW (p=0.02) [OR 2.7 (95{\%} CI 1.2-6.3)]. Boys had an increased risk of developing RW (p=0.003) [OR 3.1 (95{\%} CI 1.5-6.5)]. No difference was found between nutrition groups. None developed food allergy. Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life.",
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author = "Gitte Zachariassen and Jan Faerk and Kj{\ae}r, {Birgitte Esberg Boysen} and Jesper Fenger-Gron and Mortensen, {Sven Aage} and Christesen, {Henrik T} and Susanne Halken",
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Allergic diseases among very preterm infants according to nutrition after hospital discharge. / Zachariassen, Gitte; Faerk, Jan; Kjær, Birgitte Esberg Boysen; Fenger-Gron, Jesper; Mortensen, Sven Aage; Christesen, Henrik T; Halken, Susanne.

I: Pediatric Allergy and Immunology, Bind 22, Nr. 5, 2011, s. 515-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Allergic diseases among very preterm infants according to nutrition after hospital discharge

AU - Zachariassen, Gitte

AU - Faerk, Jan

AU - Kjær, Birgitte Esberg Boysen

AU - Fenger-Gron, Jesper

AU - Mortensen, Sven Aage

AU - Christesen, Henrik T

AU - Halken, Susanne

N1 - © 2011 John Wiley & Sons A/S.

PY - 2011

Y1 - 2011

N2 - To determine whether a cow's milk-based human milk fortifier (HMF) added to mother's milk while breastfeeding or a cow's milk-based preterm formula compared to exclusively mother's milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life. Of a cohort of 324 VPI (gestational age 24-32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA. The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2% and 32.7%, while atopic dermatitis (AD) was 18.0% and 12.1%, respectively. Predisposition to allergic disease increased the risk of developing AD (p=0.04) [OR 2.6 (95% CI 1.0-6.4)] and the risk of developing RW (p=0.02) [OR 2.7 (95% CI 1.2-6.3)]. Boys had an increased risk of developing RW (p=0.003) [OR 3.1 (95% CI 1.5-6.5)]. No difference was found between nutrition groups. None developed food allergy. Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life.

AB - To determine whether a cow's milk-based human milk fortifier (HMF) added to mother's milk while breastfeeding or a cow's milk-based preterm formula compared to exclusively mother's milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life. Of a cohort of 324 VPI (gestational age 24-32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA. The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2% and 32.7%, while atopic dermatitis (AD) was 18.0% and 12.1%, respectively. Predisposition to allergic disease increased the risk of developing AD (p=0.04) [OR 2.6 (95% CI 1.0-6.4)] and the risk of developing RW (p=0.02) [OR 2.7 (95% CI 1.2-6.3)]. Boys had an increased risk of developing RW (p=0.003) [OR 3.1 (95% CI 1.5-6.5)]. No difference was found between nutrition groups. None developed food allergy. Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life.

KW - Adult

KW - Animals

KW - Breast Feeding

KW - Cattle

KW - Dermatitis, Atopic

KW - Female

KW - Gestational Age

KW - Humans

KW - Hypersensitivity, Immediate

KW - Incidence

KW - Infant

KW - Infant Food

KW - Infant, Newborn

KW - Infant, Premature

KW - Infant, Premature, Diseases

KW - Male

KW - Milk

KW - Milk, Human

KW - Prevalence

KW - Respiratory Sounds

KW - Treatment Outcome

U2 - 10.1111/j.1399-3038.2010.01102.x

DO - 10.1111/j.1399-3038.2010.01102.x

M3 - Journal article

VL - 22

SP - 515

EP - 520

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 5

ER -