Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.)

New and old sensitizers in a shrub-turned-a-pot plant

Evy Paulsen*, Mette Gade Hyldgaard, Klaus E. Andersen, Flemming Andersen, Lars P. Christensen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.

OBJECTIVES: To assess the sensitizing potential of sesquiterpene lactones from cushion bush.

PATIENTS/MATERIALS/METHODS: Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.

RESULTS: Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.

CONCLUSIONS: The well-known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4α-hydroxy-5αH,10αH-1,11(13)-guaidien-8β,12-olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.

OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind76
Udgave nummer5
Sider (fra-til)280-286
ISSN0105-1873
DOI
StatusUdgivet - 2017

Fingeraftryk

Lactones
Asteraceae
Patch Tests
Allergens
calocephalin

Citer dette

@article{fe0d83522c644a11ad008857e1344eea,
title = "Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.): New and old sensitizers in a shrub-turned-a-pot plant",
abstract = "BACKGROUND: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.OBJECTIVES: To assess the sensitizing potential of sesquiterpene lactones from cushion bush.PATIENTS/MATERIALS/METHODS: Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.RESULTS: Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.CONCLUSIONS: The well-known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4α-hydroxy-5αH,10αH-1,11(13)-guaidien-8β,12-olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.",
keywords = "Asteraceae, Calocephalin, Compositae, Cushion bush: Leucophyta brownii, Leucophytalin A, Pseudoivalin, Tomentosin",
author = "Evy Paulsen and {Gade Hyldgaard}, Mette and Andersen, {Klaus E.} and Flemming Andersen and Christensen, {Lars P.}",
note = "{\circledC} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2017",
doi = "10.1111/cod.12757",
language = "English",
volume = "76",
pages = "280--286",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "5",

}

Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.) : New and old sensitizers in a shrub-turned-a-pot plant. / Paulsen, Evy; Gade Hyldgaard, Mette; Andersen, Klaus E.; Andersen, Flemming; Christensen, Lars P.

I: Contact Dermatitis, Bind 76, Nr. 5, 2017, s. 280-286.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.)

T2 - New and old sensitizers in a shrub-turned-a-pot plant

AU - Paulsen, Evy

AU - Gade Hyldgaard, Mette

AU - Andersen, Klaus E.

AU - Andersen, Flemming

AU - Christensen, Lars P.

N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.OBJECTIVES: To assess the sensitizing potential of sesquiterpene lactones from cushion bush.PATIENTS/MATERIALS/METHODS: Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.RESULTS: Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.CONCLUSIONS: The well-known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4α-hydroxy-5αH,10αH-1,11(13)-guaidien-8β,12-olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.

AB - BACKGROUND: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.OBJECTIVES: To assess the sensitizing potential of sesquiterpene lactones from cushion bush.PATIENTS/MATERIALS/METHODS: Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.RESULTS: Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.CONCLUSIONS: The well-known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4α-hydroxy-5αH,10αH-1,11(13)-guaidien-8β,12-olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.

KW - Asteraceae

KW - Calocephalin

KW - Compositae

KW - Cushion bush: Leucophyta brownii

KW - Leucophytalin A

KW - Pseudoivalin

KW - Tomentosin

U2 - 10.1111/cod.12757

DO - 10.1111/cod.12757

M3 - Journal article

VL - 76

SP - 280

EP - 286

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 5

ER -