Alfa-synuclein in cerebrospinal fluid as a possible biomarker for Parkinson disease

Morten Juul Bøgelund Hansen; Ivan Brandslund; Erik Dalsgaard Lund; Kamaran Shorsh; Olga Andersen; Ole Jakob Vilholm

Alfa-synuclein in cerebrospinal fluid as a possible biomarker for Parkinson disease

Morten Juul Bøgelund Hansen, Ivan Brandslund, Erik Dalsgaard Lund, Kamaran Shorsh, Olga Andersen, Ole Jakob Vilholm

Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning

Abstract

Parkinson disease (PD) is one of the neurodegenerative diseases. The prevalence of PD is increasing due to the general increase of the population over 65 years. An estimate shows that there are about 6.000 – 8.000 people suffering from PD in Denmark. The pathology behind PD is loss of dopaminerge cells in substantia nigra. PD is primarily diagnosed clinically by tremor, bradykinesia, rigidity and postural instability. However, several agents have been suggested as possible biomarkers. One of these is α-synuclein.

Aim

The aim of this study is to determine if the concentration of α-synuclein and α- synuclein oligomer the in the cerebrospinal fluid can be used as a biomarker for diagnosing PD.

Design
A total of 36 patients diagnosed with PD and 36 controls matched in sex and age were included in this study. The PD patients were classified according to the Hoehn-Yahr classification. The concentration of α-synuclein and the α-synuclein oligomer were determined with the use of ELISA technique.

Results
At this time, we are making preparations for the biochemical analysis. We hope that this study can help determine if α-synuclein and the oligomer can be used as a reliable biomarker for PD.

Originalsprog	Dansk
Publikationsdato	24. apr. 2014
Antal sider	1
Status	Udgivet - 24. apr. 2014
Begivenhed	Åbent forskerdag 2014 - Trinity Hotel & Conference Centre, Fredericia, Danmark Varighed: 24. apr. 2014 → 24. apr. 2014 https://www.regionsyddanmark.dk/wm334221

Konference

Konference	Åbent forskerdag 2014
Lokation	Trinity Hotel & Conference Centre
Land/Område	Danmark
By	Fredericia
Periode	24/04/2014 → 24/04/2014
Internetadresse	https://www.regionsyddanmark.dk/wm334221

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Alfa-synuclein in cerebrospinal fluid as a possible biomarker for Parkinson disease",

abstract = "Parkinson disease (PD) is one of the neurodegenerative diseases. The prevalence of PD is increasing due to the general increase of the population over 65 years. An estimate shows that there are about 6.000 – 8.000 people suffering from PD in Denmark. The pathology behind PD is loss of dopaminerge cells in substantia nigra. PD is primarily diagnosed clinically by tremor, bradykinesia, rigidity and postural instability. However, several agents have been suggested as possible biomarkers. One of these is α-synuclein.Aim The aim of this study is to determine if the concentration of α-synuclein and α- synuclein oligomer the in the cerebrospinal fluid can be used as a biomarker for diagnosing PD.DesignA total of 36 patients diagnosed with PD and 36 controls matched in sex and age were included in this study. The PD patients were classified according to the Hoehn-Yahr classification. The concentration of α-synuclein and the α-synuclein oligomer were determined with the use of ELISA technique. ResultsAt this time, we are making preparations for the biochemical analysis. We hope that this study can help determine if α-synuclein and the oligomer can be used as a reliable biomarker for PD.",

author = "{Juul B{\o}gelund Hansen}, Morten and Ivan Brandslund and {Dalsgaard Lund}, Erik and Kamaran Shorsh and Olga Andersen and Vilholm, {Ole Jakob}",

year = "2014",

month = apr,

day = "24",

language = "Dansk",

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TY - ABST

T1 - Alfa-synuclein in cerebrospinal fluid as a possible biomarker for Parkinson disease

AU - Juul Bøgelund Hansen, Morten

AU - Brandslund, Ivan

AU - Dalsgaard Lund, Erik

AU - Shorsh, Kamaran

AU - Andersen, Olga

AU - Vilholm, Ole Jakob

PY - 2014/4/24

Y1 - 2014/4/24

N2 - Parkinson disease (PD) is one of the neurodegenerative diseases. The prevalence of PD is increasing due to the general increase of the population over 65 years. An estimate shows that there are about 6.000 – 8.000 people suffering from PD in Denmark. The pathology behind PD is loss of dopaminerge cells in substantia nigra. PD is primarily diagnosed clinically by tremor, bradykinesia, rigidity and postural instability. However, several agents have been suggested as possible biomarkers. One of these is α-synuclein.Aim The aim of this study is to determine if the concentration of α-synuclein and α- synuclein oligomer the in the cerebrospinal fluid can be used as a biomarker for diagnosing PD.DesignA total of 36 patients diagnosed with PD and 36 controls matched in sex and age were included in this study. The PD patients were classified according to the Hoehn-Yahr classification. The concentration of α-synuclein and the α-synuclein oligomer were determined with the use of ELISA technique. ResultsAt this time, we are making preparations for the biochemical analysis. We hope that this study can help determine if α-synuclein and the oligomer can be used as a reliable biomarker for PD.

AB - Parkinson disease (PD) is one of the neurodegenerative diseases. The prevalence of PD is increasing due to the general increase of the population over 65 years. An estimate shows that there are about 6.000 – 8.000 people suffering from PD in Denmark. The pathology behind PD is loss of dopaminerge cells in substantia nigra. PD is primarily diagnosed clinically by tremor, bradykinesia, rigidity and postural instability. However, several agents have been suggested as possible biomarkers. One of these is α-synuclein.Aim The aim of this study is to determine if the concentration of α-synuclein and α- synuclein oligomer the in the cerebrospinal fluid can be used as a biomarker for diagnosing PD.DesignA total of 36 patients diagnosed with PD and 36 controls matched in sex and age were included in this study. The PD patients were classified according to the Hoehn-Yahr classification. The concentration of α-synuclein and the α-synuclein oligomer were determined with the use of ELISA technique. ResultsAt this time, we are making preparations for the biochemical analysis. We hope that this study can help determine if α-synuclein and the oligomer can be used as a reliable biomarker for PD.

M3 - Konferenceabstrakt til konference

T2 - Åbent forskerdag 2014

Y2 - 24 April 2014 through 24 April 2014

ER -