Aldersrelaterede forskelle i kræftbiologi hos ældre

Odd Lilleng Gammelgaard; Per Guldberg; Morten Frier Gjerstorff; Henrik Jørn Ditzel

Aldersrelaterede forskelle i kræftbiologi hos ældre

Odd Lilleng Gammelgaard^*
, Per Guldberg
, Morten Frier Gjerstorff
, Henrik Jørn Ditzel

^*Kontaktforfatter

Kræftens Bekæmpelse

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Aging impacts cancer development with incidence rising exponentially. Age-related genetic and epigenetic changes, along with the aging microenvironment, contribute to cancer development. In older individuals, tumours manifest a heightened mutational burden and distinct genetic changes which differ significantly from tumours observed in younger patients. The aging microenvironment accumulates senescent cells, altered matrix, and a dysregulated immune system. Age-related changes in the immune system fuel tumour development and treatment resistance. Understanding these processes is crucial for optimized treatment of older patients with cancer, as discussed in this review.

Bidragets oversatte titel	Age-related differences in cancer biology in older patients
Originalsprog	Dansk
Artikelnummer	V07230474
Tidsskrift	Ugeskrift for Læger
Vol/bind	186
Udgave nummer	2
Sider (fra-til)	135-138
ISSN	0041-5782
Status	Udgivet - 22. jan. 2024

Dokumenter og links

Open Access VersionForlagets udgivne version, 460 KBLicens: CC BY-NC-ND

https://ugeskriftet.dk/videnskab/aldersrelaterede-forskelle-i-kraeftbiologi-hos-aeldreLicens: CC BY-NC-ND

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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T1 - Aldersrelaterede forskelle i kræftbiologi hos ældre

AU - Gammelgaard, Odd Lilleng

AU - Guldberg, Per

AU - Gjerstorff, Morten Frier

AU - Ditzel, Henrik Jørn

PY - 2024/1/22

Y1 - 2024/1/22

N2 - Aging impacts cancer development with incidence rising exponentially. Age-related genetic and epigenetic changes, along with the aging microenvironment, contribute to cancer development. In older individuals, tumours manifest a heightened mutational burden and distinct genetic changes which differ significantly from tumours observed in younger patients. The aging microenvironment accumulates senescent cells, altered matrix, and a dysregulated immune system. Age-related changes in the immune system fuel tumour development and treatment resistance. Understanding these processes is crucial for optimized treatment of older patients with cancer, as discussed in this review.

AB - Aging impacts cancer development with incidence rising exponentially. Age-related genetic and epigenetic changes, along with the aging microenvironment, contribute to cancer development. In older individuals, tumours manifest a heightened mutational burden and distinct genetic changes which differ significantly from tumours observed in younger patients. The aging microenvironment accumulates senescent cells, altered matrix, and a dysregulated immune system. Age-related changes in the immune system fuel tumour development and treatment resistance. Understanding these processes is crucial for optimized treatment of older patients with cancer, as discussed in this review.

M3 - Tidsskriftartikel

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JO - Ugeskrift for Læger

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Aldersrelaterede forskelle i kræftbiologi hos ældre

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater