Alcohol use as predictor for infertility in a representative population of Danish women

Janne Schurmann Tolstrup, Susanne Krüger Kjaer, Claus Holst, Heidi Sharif, Christian Munk, Merete Osler, Lone Schmidt, Anne-Marie Nybo Andersen, Morten Grønbaek

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2003-Aug
OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind82
Udgave nummer8
Sider (fra-til)744-9
Antal sider5
ISSN0001-6349
StatusUdgivet - 1. aug. 2003

Fingeraftryk

Infertility
Alcohols
Population
Age Groups
Incidence
Marital Status
Proportional Hazards Models
Smoking
Outcome Assessment (Health Care)
Confidence Intervals
Education

Citer dette

Tolstrup, Janne Schurmann ; Kjaer, Susanne Krüger ; Holst, Claus ; Sharif, Heidi ; Munk, Christian ; Osler, Merete ; Schmidt, Lone ; Andersen, Anne-Marie Nybo ; Grønbaek, Morten. / Alcohol use as predictor for infertility in a representative population of Danish women. I: Acta Obstetricia et Gynecologica Scandinavica. 2003 ; Bind 82, Nr. 8. s. 744-9.
@article{3341f650e0bb11dd9909000ea68e967b,
title = "Alcohol use as predictor for infertility in a representative population of Danish women",
abstract = "BACKGROUND: Our aim was to examine the association between use of alcohol and subsequent incidence of primary infertility. METHODS: The study subjects were chosen from a population-based cohort of Danish women aged 20-29 years. Eligible women were nulliparous and not pregnant (n = 7760). Information on alcohol intake and potential confounders (age, education, marital status, diseases in the reproductive organs, and cigarette smoking) was assessed at enrollment. The incidence of fertility problems during follow-up was obtained by record linkage with the Danish Hospital Discharge Register and the Danish Infertility Cohort Register. Main outcome measures were hazard ratios of infertility according to alcohol intake at baseline estimated in a multivariate Cox proportional hazards model. RESULTS: During a mean follow-up of 4.9 years, 368 women had experienced infertility. Alcohol intake at baseline was unassociated with infertility among younger women, but was a significant predictor for infertility among women above age 30. In this age group, the adjusted hazard ratio for consuming seven or more drinks per week was 2.26 (95{\%} confidence interval: 1.19-4.32) compared with women consuming less than one drink per week. CONCLUSIONS: These findings suggest that alcohol intake is a predictor for infertility problems among women in the later reproductive age group.",
keywords = "Adult, Alcohol Drinking, Cohort Studies, Denmark, Female, Follow-Up Studies, Humans, Incidence, Infertility, Female, Maternal Age, Population Surveillance, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, Risk Factors, Socioeconomic Factors",
author = "Tolstrup, {Janne Schurmann} and Kjaer, {Susanne Kr{\"u}ger} and Claus Holst and Heidi Sharif and Christian Munk and Merete Osler and Lone Schmidt and Andersen, {Anne-Marie Nybo} and Morten Gr{\o}nbaek",
year = "2003",
month = "8",
day = "1",
language = "English",
volume = "82",
pages = "744--9",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
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Tolstrup, JS, Kjaer, SK, Holst, C, Sharif, H, Munk, C, Osler, M, Schmidt, L, Andersen, A-MN & Grønbaek, M 2003, 'Alcohol use as predictor for infertility in a representative population of Danish women', Acta Obstetricia et Gynecologica Scandinavica, bind 82, nr. 8, s. 744-9.

Alcohol use as predictor for infertility in a representative population of Danish women. / Tolstrup, Janne Schurmann; Kjaer, Susanne Krüger; Holst, Claus; Sharif, Heidi; Munk, Christian; Osler, Merete; Schmidt, Lone; Andersen, Anne-Marie Nybo; Grønbaek, Morten.

I: Acta Obstetricia et Gynecologica Scandinavica, Bind 82, Nr. 8, 01.08.2003, s. 744-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Alcohol use as predictor for infertility in a representative population of Danish women

AU - Tolstrup, Janne Schurmann

AU - Kjaer, Susanne Krüger

AU - Holst, Claus

AU - Sharif, Heidi

AU - Munk, Christian

AU - Osler, Merete

AU - Schmidt, Lone

AU - Andersen, Anne-Marie Nybo

AU - Grønbaek, Morten

PY - 2003/8/1

Y1 - 2003/8/1

N2 - BACKGROUND: Our aim was to examine the association between use of alcohol and subsequent incidence of primary infertility. METHODS: The study subjects were chosen from a population-based cohort of Danish women aged 20-29 years. Eligible women were nulliparous and not pregnant (n = 7760). Information on alcohol intake and potential confounders (age, education, marital status, diseases in the reproductive organs, and cigarette smoking) was assessed at enrollment. The incidence of fertility problems during follow-up was obtained by record linkage with the Danish Hospital Discharge Register and the Danish Infertility Cohort Register. Main outcome measures were hazard ratios of infertility according to alcohol intake at baseline estimated in a multivariate Cox proportional hazards model. RESULTS: During a mean follow-up of 4.9 years, 368 women had experienced infertility. Alcohol intake at baseline was unassociated with infertility among younger women, but was a significant predictor for infertility among women above age 30. In this age group, the adjusted hazard ratio for consuming seven or more drinks per week was 2.26 (95% confidence interval: 1.19-4.32) compared with women consuming less than one drink per week. CONCLUSIONS: These findings suggest that alcohol intake is a predictor for infertility problems among women in the later reproductive age group.

AB - BACKGROUND: Our aim was to examine the association between use of alcohol and subsequent incidence of primary infertility. METHODS: The study subjects were chosen from a population-based cohort of Danish women aged 20-29 years. Eligible women were nulliparous and not pregnant (n = 7760). Information on alcohol intake and potential confounders (age, education, marital status, diseases in the reproductive organs, and cigarette smoking) was assessed at enrollment. The incidence of fertility problems during follow-up was obtained by record linkage with the Danish Hospital Discharge Register and the Danish Infertility Cohort Register. Main outcome measures were hazard ratios of infertility according to alcohol intake at baseline estimated in a multivariate Cox proportional hazards model. RESULTS: During a mean follow-up of 4.9 years, 368 women had experienced infertility. Alcohol intake at baseline was unassociated with infertility among younger women, but was a significant predictor for infertility among women above age 30. In this age group, the adjusted hazard ratio for consuming seven or more drinks per week was 2.26 (95% confidence interval: 1.19-4.32) compared with women consuming less than one drink per week. CONCLUSIONS: These findings suggest that alcohol intake is a predictor for infertility problems among women in the later reproductive age group.

KW - Adult

KW - Alcohol Drinking

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Infertility, Female

KW - Maternal Age

KW - Population Surveillance

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Socioeconomic Factors

M3 - Journal article

C2 - 12848646

VL - 82

SP - 744

EP - 749

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 8

ER -