Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth: A Cohort Study

Louise Katrine Kjaer Weile, Hanne Kirstine Hegaard, Chunsen Wu, Ann Tabor, Hanne Trap Wolf, Ulrik Schiøler Kesmodel, Tine Brink Henriksen, Ellen Aagaard Nohr

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Limited research has addressed whether maternal alcohol intake in early pregnancy increases the risk of spontaneous preterm birth. In the current study, we examined how alcohol binge drinking and weekly alcohol intake in early pregnancy were associated with spontaneous preterm birth in a contemporary cohort of Danish women.

METHODS: We included 15,776 pregnancies of 14,894 women referred to antenatal care at Copenhagen University Hospital, Denmark, between 2012 and 2016. Self-reported alcohol intake in early pregnancy was obtained from a Web-based questionnaire completed prior to the women's first visit at the department. Information on spontaneous preterm birth was extracted from the Danish Medical Birth Register. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of spontaneous preterm birth according to self-reported alcohol binge drinking and weekly intake of alcohol in early pregnancy were derived from Cox regression.

RESULTS: Women reporting 1, 2, and ≥ 3 binge drinking episodes had an aHR for spontaneous preterm birth of 0.88 (95% CI 0.68 to 1.14), 1.34 (95% CI 0.98 to 1.82), and 0.93 (95% CI 0.62 to 1.41), respectively, compared to women with no binge drinking episodes. Women who reported an intake of ≥ 1 drink per week on average had an aHR for spontaneous preterm birth of 1.09 (95% CI 0.63 to 1.89) compared to abstainers. When restricting to nulliparous women or cohabiting women with ≥ 3 years of higher education, this estimate was 1.28 (95% CI 0.69 to 2.40) and 1.20 (95% CI 0.67 to 2.15), respectively.

CONCLUSION: We found no evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol.

OriginalsprogEngelsk
TidsskriftAlcoholism: Clinical and Experimental Research
Vol/bind44
Udgave nummer2
Sider (fra-til)511-521
ISSN0145-6008
DOI
StatusUdgivet - feb. 2020

Fingeraftryk

Premature Birth
Cohort Studies
Alcohols
Confidence Intervals
Alcohol Drinking
Mothers
Prenatal Care
Denmark
Hazards
Education
Research

Bibliografisk note

© 2019 by the Research Society on Alcoholism.

Citer dette

Weile, Louise Katrine Kjaer ; Hegaard, Hanne Kirstine ; Wu, Chunsen ; Tabor, Ann ; Wolf, Hanne Trap ; Kesmodel, Ulrik Schiøler ; Henriksen, Tine Brink ; Nohr, Ellen Aagaard. / Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth : A Cohort Study. I: Alcoholism: Clinical and Experimental Research. 2020 ; Bind 44, Nr. 2. s. 511-521.
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title = "Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth: A Cohort Study",
abstract = "BACKGROUND: Limited research has addressed whether maternal alcohol intake in early pregnancy increases the risk of spontaneous preterm birth. In the current study, we examined how alcohol binge drinking and weekly alcohol intake in early pregnancy were associated with spontaneous preterm birth in a contemporary cohort of Danish women.METHODS: We included 15,776 pregnancies of 14,894 women referred to antenatal care at Copenhagen University Hospital, Denmark, between 2012 and 2016. Self-reported alcohol intake in early pregnancy was obtained from a Web-based questionnaire completed prior to the women's first visit at the department. Information on spontaneous preterm birth was extracted from the Danish Medical Birth Register. Adjusted hazard ratios (aHRs) with 95{\%} confidence intervals (CIs) of spontaneous preterm birth according to self-reported alcohol binge drinking and weekly intake of alcohol in early pregnancy were derived from Cox regression.RESULTS: Women reporting 1, 2, and ≥ 3 binge drinking episodes had an aHR for spontaneous preterm birth of 0.88 (95{\%} CI 0.68 to 1.14), 1.34 (95{\%} CI 0.98 to 1.82), and 0.93 (95{\%} CI 0.62 to 1.41), respectively, compared to women with no binge drinking episodes. Women who reported an intake of ≥ 1 drink per week on average had an aHR for spontaneous preterm birth of 1.09 (95{\%} CI 0.63 to 1.89) compared to abstainers. When restricting to nulliparous women or cohabiting women with ≥ 3 years of higher education, this estimate was 1.28 (95{\%} CI 0.69 to 2.40) and 1.20 (95{\%} CI 0.67 to 2.15), respectively.CONCLUSION: We found no evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol.",
author = "Weile, {Louise Katrine Kjaer} and Hegaard, {Hanne Kirstine} and Chunsen Wu and Ann Tabor and Wolf, {Hanne Trap} and Kesmodel, {Ulrik Schi{\o}ler} and Henriksen, {Tine Brink} and Nohr, {Ellen Aagaard}",
note = "{\circledC} 2019 by the Research Society on Alcoholism.",
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Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth : A Cohort Study. / Weile, Louise Katrine Kjaer; Hegaard, Hanne Kirstine; Wu, Chunsen; Tabor, Ann; Wolf, Hanne Trap; Kesmodel, Ulrik Schiøler; Henriksen, Tine Brink; Nohr, Ellen Aagaard.

I: Alcoholism: Clinical and Experimental Research, Bind 44, Nr. 2, 02.2020, s. 511-521.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Alcohol Intake in Early Pregnancy and Spontaneous Preterm Birth

T2 - A Cohort Study

AU - Weile, Louise Katrine Kjaer

AU - Hegaard, Hanne Kirstine

AU - Wu, Chunsen

AU - Tabor, Ann

AU - Wolf, Hanne Trap

AU - Kesmodel, Ulrik Schiøler

AU - Henriksen, Tine Brink

AU - Nohr, Ellen Aagaard

N1 - © 2019 by the Research Society on Alcoholism.

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND: Limited research has addressed whether maternal alcohol intake in early pregnancy increases the risk of spontaneous preterm birth. In the current study, we examined how alcohol binge drinking and weekly alcohol intake in early pregnancy were associated with spontaneous preterm birth in a contemporary cohort of Danish women.METHODS: We included 15,776 pregnancies of 14,894 women referred to antenatal care at Copenhagen University Hospital, Denmark, between 2012 and 2016. Self-reported alcohol intake in early pregnancy was obtained from a Web-based questionnaire completed prior to the women's first visit at the department. Information on spontaneous preterm birth was extracted from the Danish Medical Birth Register. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of spontaneous preterm birth according to self-reported alcohol binge drinking and weekly intake of alcohol in early pregnancy were derived from Cox regression.RESULTS: Women reporting 1, 2, and ≥ 3 binge drinking episodes had an aHR for spontaneous preterm birth of 0.88 (95% CI 0.68 to 1.14), 1.34 (95% CI 0.98 to 1.82), and 0.93 (95% CI 0.62 to 1.41), respectively, compared to women with no binge drinking episodes. Women who reported an intake of ≥ 1 drink per week on average had an aHR for spontaneous preterm birth of 1.09 (95% CI 0.63 to 1.89) compared to abstainers. When restricting to nulliparous women or cohabiting women with ≥ 3 years of higher education, this estimate was 1.28 (95% CI 0.69 to 2.40) and 1.20 (95% CI 0.67 to 2.15), respectively.CONCLUSION: We found no evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol.

AB - BACKGROUND: Limited research has addressed whether maternal alcohol intake in early pregnancy increases the risk of spontaneous preterm birth. In the current study, we examined how alcohol binge drinking and weekly alcohol intake in early pregnancy were associated with spontaneous preterm birth in a contemporary cohort of Danish women.METHODS: We included 15,776 pregnancies of 14,894 women referred to antenatal care at Copenhagen University Hospital, Denmark, between 2012 and 2016. Self-reported alcohol intake in early pregnancy was obtained from a Web-based questionnaire completed prior to the women's first visit at the department. Information on spontaneous preterm birth was extracted from the Danish Medical Birth Register. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of spontaneous preterm birth according to self-reported alcohol binge drinking and weekly intake of alcohol in early pregnancy were derived from Cox regression.RESULTS: Women reporting 1, 2, and ≥ 3 binge drinking episodes had an aHR for spontaneous preterm birth of 0.88 (95% CI 0.68 to 1.14), 1.34 (95% CI 0.98 to 1.82), and 0.93 (95% CI 0.62 to 1.41), respectively, compared to women with no binge drinking episodes. Women who reported an intake of ≥ 1 drink per week on average had an aHR for spontaneous preterm birth of 1.09 (95% CI 0.63 to 1.89) compared to abstainers. When restricting to nulliparous women or cohabiting women with ≥ 3 years of higher education, this estimate was 1.28 (95% CI 0.69 to 2.40) and 1.20 (95% CI 0.67 to 2.15), respectively.CONCLUSION: We found no evidence that maternal alcohol intake in early pregnancy was associated with a higher risk of spontaneous preterm birth, neither for alcohol binge drinking nor for a low average weekly intake of alcohol.

U2 - 10.1111/acer.14257

DO - 10.1111/acer.14257

M3 - Journal article

C2 - 31803953

VL - 44

SP - 511

EP - 521

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 2

ER -